Cardiovascular predictors for long-term mortality after EVAR for AAA
Ohrlander, Tomas ; Dencker, Magnus LU ; Dias, Nuno LU
; Gottsäter, Anders
LU
and Acosta, Stefan
LU
(2011)
In Vascular Medicine
16(6).
p.422-427
- Abstract
- The aim of this study was to assess cardiovascular predictors for all-cause long-term mortality in patients undergoing standard endovascular aneurysm repair (EVAR) for infrarenal abdominal aortic aneurysm (AAA). Consecutive patients treated with EVAR (Zenith (R) stent grafts; Cook) between May 1998 and February 2006 were prospectively enrolled in a computerized database, together with retrospectively collected data on medication, and electrocardiographic and echocardiographic variables. Mortality was assessed on 1 December 2010. The median follow-up time was 68 months and the median age was 74 years (range 53-89) for the 304 patients. Mortality at the end of follow-up was 54.3% (165/304). The proportion of deaths caused by vascular... (More)
- The aim of this study was to assess cardiovascular predictors for all-cause long-term mortality in patients undergoing standard endovascular aneurysm repair (EVAR) for infrarenal abdominal aortic aneurysm (AAA). Consecutive patients treated with EVAR (Zenith (R) stent grafts; Cook) between May 1998 and February 2006 were prospectively enrolled in a computerized database, together with retrospectively collected data on medication, and electrocardiographic and echocardiographic variables. Mortality was assessed on 1 December 2010. The median follow-up time was 68 months and the median age was 74 years (range 53-89) for the 304 patients. Mortality at the end of follow-up was 54.3% (165/304). The proportion of deaths caused by vascular diseases was 61% (101/165). In the univariate analysis, low preoperative ejection fraction (EF) (p = 0.004), absence of statin medication (p = 0.007), and medication with diuretics (p = 0.028) or digitalis (p = 0.016) were associated with an increased long-term mortality rate. Myocardial ischemia on electrocardiogram (ECG) (hazard ratio (HR) 1.6 [95% CI 1.1-2.4]) and anemia (HR 1.5 [95% CI 1.0-2.1]) were found to be independent predictors for long-term mortality after Cox regression analysis. There was a trend that chronic kidney disease, stage >= 3 (HR 1.5 [95% CI 1.0-2.2]), and age 80 years and above (HR 1.5 [95% CI 1.0-2.4]) were independently associated with long-term mortality. In conclusion, ischemia on ECG and anemia were independently related to an increased long-term mortality rate after EVAR, and these predictive factors seem to be most important for critical assessment in the preoperative medical work-up. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2279333
- author
- Ohrlander, Tomas
; Dencker, Magnus
LU
; Dias, Nuno
LU
; Gottsäter, Anders
LU
and Acosta, Stefan
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- anemia, cardiovascular, echocardiography, electrocardiogram, EVAR, mortality
- in
- Vascular Medicine
- volume
- 16
- issue
- 6
- pages
- 422 - 427
- publisher
- SAGE Publications
- external identifiers
-
- wos:000297480100002
- scopus:82955247125
- pmid:22128041
- ISSN
- 1477-0377
- DOI
- 10.1177/1358863X11425713
- language
- English
- LU publication?
- yes
- id
- ce9482d6-cbc8-49a1-923b-3afba52d0f8c (old id 2279333)
- date added to LUP
- 2016-04-01 10:06:20
- date last changed
- 2023-08-30 17:45:58
@article{ce9482d6-cbc8-49a1-923b-3afba52d0f8c,
abstract = {{The aim of this study was to assess cardiovascular predictors for all-cause long-term mortality in patients undergoing standard endovascular aneurysm repair (EVAR) for infrarenal abdominal aortic aneurysm (AAA). Consecutive patients treated with EVAR (Zenith (R) stent grafts; Cook) between May 1998 and February 2006 were prospectively enrolled in a computerized database, together with retrospectively collected data on medication, and electrocardiographic and echocardiographic variables. Mortality was assessed on 1 December 2010. The median follow-up time was 68 months and the median age was 74 years (range 53-89) for the 304 patients. Mortality at the end of follow-up was 54.3% (165/304). The proportion of deaths caused by vascular diseases was 61% (101/165). In the univariate analysis, low preoperative ejection fraction (EF) (p = 0.004), absence of statin medication (p = 0.007), and medication with diuretics (p = 0.028) or digitalis (p = 0.016) were associated with an increased long-term mortality rate. Myocardial ischemia on electrocardiogram (ECG) (hazard ratio (HR) 1.6 [95% CI 1.1-2.4]) and anemia (HR 1.5 [95% CI 1.0-2.1]) were found to be independent predictors for long-term mortality after Cox regression analysis. There was a trend that chronic kidney disease, stage >= 3 (HR 1.5 [95% CI 1.0-2.2]), and age 80 years and above (HR 1.5 [95% CI 1.0-2.4]) were independently associated with long-term mortality. In conclusion, ischemia on ECG and anemia were independently related to an increased long-term mortality rate after EVAR, and these predictive factors seem to be most important for critical assessment in the preoperative medical work-up.}},
author = {{Ohrlander, Tomas and Dencker, Magnus and Dias, Nuno and Gottsäter, Anders and Acosta, Stefan}},
issn = {{1477-0377}},
keywords = {{anemia; cardiovascular; echocardiography; electrocardiogram; EVAR; mortality}},
language = {{eng}},
number = {{6}},
pages = {{422--427}},
publisher = {{SAGE Publications}},
series = {{Vascular Medicine}},
title = {{Cardiovascular predictors for long-term mortality after EVAR for AAA}},
url = {{http://dx.doi.org/10.1177/1358863X11425713}},
doi = {{10.1177/1358863X11425713}},
volume = {{16}},
year = {{2011}},
}