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RELATIONSHIP BETWEEN CYTOGENETIC FINDINGS AND HISTOPATHOLOGY IN NON‐HODGKIN LYMPHOMA

KRISTOFFERSSON, ULF LU ; HEIM, SVERRE LU ; OLSSON, HÅKAN LU ; ÅKERMAN, MÅNS LU and MITELMAN, FELIX LU (1987) In Acta Pathologica Microbiologica Scandinavica Series A :Pathology 95 A(1-6). p.1-5
Abstract

The cytogenetic findings in 70 patients with non‐Hodgkin lymphoma have been correlated with tumor histopathology according to the Kiel classification. Certain chromosome aberrations displayed a nonrandom association with the grade of malignancy: 4 lymphomas out of 6 with 1p+, 5 out of 7 with del(6)(q15), 7 out of 11 with 14q+, and 5 out of 8 with +18 belonged to the high grade malignancy group, whereas 9 lymphomas out of 10 with t(14;18) were low grade malignant. Two aberration types were closely associated with specific histopathologic subtypes: t(14; 18) occurred in 7 cases out of 10 in centroblastic/ centrocytic (cb/cc) follicular lymphomas, and 5 cases out of 6 with i(17q) were cb or cb/cc. Although less striking, there was a... (More)

The cytogenetic findings in 70 patients with non‐Hodgkin lymphoma have been correlated with tumor histopathology according to the Kiel classification. Certain chromosome aberrations displayed a nonrandom association with the grade of malignancy: 4 lymphomas out of 6 with 1p+, 5 out of 7 with del(6)(q15), 7 out of 11 with 14q+, and 5 out of 8 with +18 belonged to the high grade malignancy group, whereas 9 lymphomas out of 10 with t(14;18) were low grade malignant. Two aberration types were closely associated with specific histopathologic subtypes: t(14; 18) occurred in 7 cases out of 10 in centroblastic/ centrocytic (cb/cc) follicular lymphomas, and 5 cases out of 6 with i(17q) were cb or cb/cc. Although less striking, there was a tendency for del(6)(q15) to occur in cb or cb/cc lymphomas (4 cases out of 7), in contrast to only 1 case out of 5 with the more distal deletion del(6)(q21).

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cytogenetic correlations, Kiel‐classification, Non‐Hodgkin lymphoma
in
Acta Pathologica Microbiologica Scandinavica Series A :Pathology
volume
95 A
issue
1-6
pages
1 - 5
publisher
John Wiley & Sons
external identifiers
  • scopus:0023147712
ISSN
0108-0164
DOI
10.1111/j.1699-0463.1987.tb00001_95A.x
language
English
LU publication?
yes
id
cf274940-f2e8-4752-970d-b1e602fda9f1
date added to LUP
2018-12-17 16:46:56
date last changed
2019-01-06 14:20:22
@article{cf274940-f2e8-4752-970d-b1e602fda9f1,
  abstract     = {<p>The cytogenetic findings in 70 patients with non‐Hodgkin lymphoma have been correlated with tumor histopathology according to the Kiel classification. Certain chromosome aberrations displayed a nonrandom association with the grade of malignancy: 4 lymphomas out of 6 with 1p+, 5 out of 7 with del(6)(q15), 7 out of 11 with 14q+, and 5 out of 8 with +18 belonged to the high grade malignancy group, whereas 9 lymphomas out of 10 with t(14;18) were low grade malignant. Two aberration types were closely associated with specific histopathologic subtypes: t(14; 18) occurred in 7 cases out of 10 in centroblastic/ centrocytic (cb/cc) follicular lymphomas, and 5 cases out of 6 with i(17q) were cb or cb/cc. Although less striking, there was a tendency for del(6)(q15) to occur in cb or cb/cc lymphomas (4 cases out of 7), in contrast to only 1 case out of 5 with the more distal deletion del(6)(q21).</p>},
  author       = {KRISTOFFERSSON, ULF and HEIM, SVERRE and OLSSON, HÅKAN and ÅKERMAN, MÅNS and MITELMAN, FELIX},
  issn         = {0108-0164},
  keyword      = {cytogenetic correlations,Kiel‐classification,Non‐Hodgkin lymphoma},
  language     = {eng},
  month        = {01},
  number       = {1-6},
  pages        = {1--5},
  publisher    = {John Wiley & Sons},
  series       = {Acta Pathologica Microbiologica Scandinavica Series A :Pathology},
  title        = {RELATIONSHIP BETWEEN CYTOGENETIC FINDINGS AND HISTOPATHOLOGY IN NON‐HODGKIN LYMPHOMA},
  url          = {http://dx.doi.org/10.1111/j.1699-0463.1987.tb00001_95A.x},
  volume       = {95 A},
  year         = {1987},
}