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Muscle mass, creatinine, cystatin C, and selective glomerular hypofiltration syndromes

Malmgren, Linnea LU orcid and Grubb, Anders LU orcid (2023) In Clinical Kidney Journal
Abstract
In this issue of Clinical Kidney Journal, Stehlé and colleagues demonstrate that estimation of glomerular filtration rate (GFR) by use of creatinine and a measure, total lumbar muscle cross-sectional area, reflecting the total muscle mass of an individual, is superior to GFRestimating equations based upon creatinine and demographic variables. The report by Stehlé et al demonstrates one solution to the interference of muscle mass in the use of creatinine to estimate GFR. This interference was identified already at the start in 1959 of using creatinine for estimation of GFR. Different ways of taking the muscle mass into account when creatinine-based estimations of GFR have been used generally include use of controversial race and sex... (More)
In this issue of Clinical Kidney Journal, Stehlé and colleagues demonstrate that estimation of glomerular filtration rate (GFR) by use of creatinine and a measure, total lumbar muscle cross-sectional area, reflecting the total muscle mass of an individual, is superior to GFRestimating equations based upon creatinine and demographic variables. The report by Stehlé et al demonstrates one solution to the interference of muscle mass in the use of creatinine to estimate GFR. This interference was identified already at the start in 1959 of using creatinine for estimation of GFR. Different ways of taking the muscle mass into account when creatinine-based estimations of GFR have been used generally include use of controversial race and sex coefficients. A new marker of GFR, cystatin C, introduced in 1979, has been shown to be virtually uninfluenced by muscle mass. In this editorial, the simultaneous use of creatinine and cystatin C to estimate GFR, muscle mass and selective glomerular hypofiltration syndromes is described. (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cystatin C, creatinine, GFR,, selective glomerular hypofiltration
in
Clinical Kidney Journal
publisher
Oxford University Press
external identifiers
  • pmid:37529657
ISSN
2048-8505
DOI
10.1093/ckj/sfad086
language
English
LU publication?
yes
id
d12d22b7-ac46-4b97-b400-90cae5c97491
date added to LUP
2023-04-23 14:39:47
date last changed
2024-01-12 02:55:32
@article{d12d22b7-ac46-4b97-b400-90cae5c97491,
  abstract     = {{In this issue of Clinical Kidney Journal, Stehlé and colleagues demonstrate that estimation of glomerular filtration rate (GFR) by use of creatinine and a measure, total lumbar muscle cross-sectional area, reflecting the total muscle mass of an individual, is superior to GFRestimating equations based upon creatinine and demographic variables. The report by Stehlé et al demonstrates one solution to the interference of muscle mass in the use of creatinine to estimate GFR. This interference was identified already at the start in 1959 of using creatinine for estimation of GFR. Different ways of taking the muscle mass into account when creatinine-based estimations of GFR have been used generally include use of controversial race and sex coefficients. A new marker of GFR, cystatin C, introduced in 1979, has been shown to be virtually uninfluenced by muscle mass. In this editorial, the simultaneous use of creatinine and cystatin C to estimate GFR, muscle mass and selective glomerular hypofiltration syndromes is described.}},
  author       = {{Malmgren, Linnea and Grubb, Anders}},
  issn         = {{2048-8505}},
  keywords     = {{cystatin C, creatinine, GFR,; selective glomerular hypofiltration}},
  language     = {{eng}},
  publisher    = {{Oxford University Press}},
  series       = {{Clinical Kidney Journal}},
  title        = {{Muscle mass, creatinine, cystatin C, and selective glomerular hypofiltration syndromes}},
  url          = {{http://dx.doi.org/10.1093/ckj/sfad086}},
  doi          = {{10.1093/ckj/sfad086}},
  year         = {{2023}},
}