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“Association of mammographic features with molecular breast tumor profiles”

Sartor, Hanna LU ; Zackrisson, Sophia LU ; Hegardt, Cecilia LU and Larsson, Christer LU (2021) In Cancer Treatment and Research Communications 28.
Abstract

Purpose: Mammographic density and tumor appearance are breast cancer prognostic factors. Conceivably, mammographic features are macroscopic reflections of tumor´s molecular composition, but to an unknown extent. Our aim was to study associations of mammographic features with molecular tumor profiles. Methods: Invasive breast cancers (2007-2016) in Malmö Diet and Cancer Study (MDCS) for which there were tumor RNA-sequencing analyses within Sweden Cancerome Analysis Network – Breast (SCAN-B) (n=102) or All Breast Cancer in Malmö (ABIM) (n=50) were identified. Density (fatty vs. dense), tumor appearance (mass vs. spiculation), and intrinsic subtypes were registered. Differences in gene/metagene expression and Microenvironment Cell... (More)

Purpose: Mammographic density and tumor appearance are breast cancer prognostic factors. Conceivably, mammographic features are macroscopic reflections of tumor´s molecular composition, but to an unknown extent. Our aim was to study associations of mammographic features with molecular tumor profiles. Methods: Invasive breast cancers (2007-2016) in Malmö Diet and Cancer Study (MDCS) for which there were tumor RNA-sequencing analyses within Sweden Cancerome Analysis Network – Breast (SCAN-B) (n=102) or All Breast Cancer in Malmö (ABIM) (n=50) were identified. Density (fatty vs. dense), tumor appearance (mass vs. spiculation), and intrinsic subtypes were registered. Differences in gene/metagene expression and Microenvironment Cell Population Counter were analyzed with R. Overall survival was used as endpoint. Results: No gene expression differences between density groups was observed. In one cohort (but not the other), Luminal A tumors associated with fatty breasts. For spiculation vs. mass, (p<0.01, t-test) 86 genes were differentially expressed; only one gene was differentially expressed comparing density. Gene set enrichment analysis showed genes highly expressed in spiculated tumors were enriched for extracellular matrix-associated genes whereas genes highly expressed with masses were associated with proliferation. A spiculation metagene, based on differentially expressed genes, showed association with estrogen receptor positivity, lower grade, and improved survival, but it was not an independent prognostic factor. Conclusion: There are clear differences in molecular composition between breast tumors with a spiculated appearance vs. a mass as the dominant tumor appearance. However, there are no apparent molecular differences related to the density of the breast in which the tumor has arisen.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breast neoplasms, Diagnostic imaging, Mammography, Survival
in
Cancer Treatment and Research Communications
volume
28
article number
100387
publisher
Elsevier
external identifiers
  • pmid:34004506
  • scopus:85110264704
ISSN
2468-2942
DOI
10.1016/j.ctarc.2021.100387
language
English
LU publication?
yes
id
d13a6366-8e38-4f29-8c4f-d9fa2f2c18a4
date added to LUP
2021-09-07 16:10:12
date last changed
2024-04-06 08:19:51
@article{d13a6366-8e38-4f29-8c4f-d9fa2f2c18a4,
  abstract     = {{<p>Purpose: Mammographic density and tumor appearance are breast cancer prognostic factors. Conceivably, mammographic features are macroscopic reflections of tumor´s molecular composition, but to an unknown extent. Our aim was to study associations of mammographic features with molecular tumor profiles. Methods: Invasive breast cancers (2007-2016) in Malmö Diet and Cancer Study (MDCS) for which there were tumor RNA-sequencing analyses within Sweden Cancerome Analysis Network – Breast (SCAN-B) (n=102) or All Breast Cancer in Malmö (ABIM) (n=50) were identified. Density (fatty vs. dense), tumor appearance (mass vs. spiculation), and intrinsic subtypes were registered. Differences in gene/metagene expression and Microenvironment Cell Population Counter were analyzed with R. Overall survival was used as endpoint. Results: No gene expression differences between density groups was observed. In one cohort (but not the other), Luminal A tumors associated with fatty breasts. For spiculation vs. mass, (p&lt;0.01, t-test) 86 genes were differentially expressed; only one gene was differentially expressed comparing density. Gene set enrichment analysis showed genes highly expressed in spiculated tumors were enriched for extracellular matrix-associated genes whereas genes highly expressed with masses were associated with proliferation. A spiculation metagene, based on differentially expressed genes, showed association with estrogen receptor positivity, lower grade, and improved survival, but it was not an independent prognostic factor. Conclusion: There are clear differences in molecular composition between breast tumors with a spiculated appearance vs. a mass as the dominant tumor appearance. However, there are no apparent molecular differences related to the density of the breast in which the tumor has arisen.</p>}},
  author       = {{Sartor, Hanna and Zackrisson, Sophia and Hegardt, Cecilia and Larsson, Christer}},
  issn         = {{2468-2942}},
  keywords     = {{Breast neoplasms; Diagnostic imaging; Mammography; Survival}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Cancer Treatment and Research Communications}},
  title        = {{“Association of mammographic features with molecular breast tumor profiles”}},
  url          = {{http://dx.doi.org/10.1016/j.ctarc.2021.100387}},
  doi          = {{10.1016/j.ctarc.2021.100387}},
  volume       = {{28}},
  year         = {{2021}},
}