Sural nerve biopsy may predict future nerve dysfunction.
(2009) In Acta Neurologica Scandinavica 120. p.38-46- Abstract
- Thrainsdottir S, Malik RA, Rosén I, Jakobsson F, Bakhtadze E, Petersson J, Sundkvist G, Dahlin LB. Sural nerve biopsy may predict future nerve dysfunction. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2008.01118.x. (c) 2008 The Authors Journal compilation (c) 2008 Blackwell Munksgaard.Objective - Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysiological tests. The aim was to investigate progression of nerve dysfunction over time in relation to a baseline nerve biopsy. Methods - Baseline myelinated nerve fiber density (MNFD) was assessed in sural nerve biopsies from 10 men with type 2 diabetes, 10 with impaired and 10 with normal glucose tolerance. Nerve conduction and quantitative... (More)
- Thrainsdottir S, Malik RA, Rosén I, Jakobsson F, Bakhtadze E, Petersson J, Sundkvist G, Dahlin LB. Sural nerve biopsy may predict future nerve dysfunction. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2008.01118.x. (c) 2008 The Authors Journal compilation (c) 2008 Blackwell Munksgaard.Objective - Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysiological tests. The aim was to investigate progression of nerve dysfunction over time in relation to a baseline nerve biopsy. Methods - Baseline myelinated nerve fiber density (MNFD) was assessed in sural nerve biopsies from 10 men with type 2 diabetes, 10 with impaired and 10 with normal glucose tolerance. Nerve conduction and quantitative perception thresholds were estimated at baseline and follow-up (7-10 years later). Results - Subjects with low MNFD (</= 4700 fibers/mm(2)) showed decline of peroneal amplitude (P < 0.02) and conduction velocity (P < 0.04), as well as median nerve sensory amplitude (P < 0.05) and motor conduction velocity (P < 0.04) from baseline to follow-up. In linear regression analyses, diabetes influenced decline of nerve conduction. MNFD correlated negatively with body mass index (r = -0.469; P < 0.02). Conclusion - Low MNFD may predict progression of neurophysiological dysfunction and links obesity to myelinated nerve fiber loss. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/record/1289506
- author
- Thrainsdottir, Soley LU ; Malik, R A; Rosén, I; Jakobsson, F; Bakhtadze, Ekaterine LU ; Petersson, Jesper LU ; Sundkvist, Göran LU and Dahlin, L B
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Neurologica Scandinavica
- volume
- 120
- pages
- 38 - 46
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000266686400005
- pmid:19154542
- scopus:66849104283
- ISSN
- 1600-0404
- DOI
- 10.1111/j.1600-0404.2008.01118.x
- language
- English
- LU publication?
- yes
- id
- d2dc7b75-7d04-499f-849f-986eecffd96d (old id 1289506)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19154542?dopt=Abstract
- date added to LUP
- 2009-02-04 12:21:33
- date last changed
- 2019-02-20 09:02:25
@article{d2dc7b75-7d04-499f-849f-986eecffd96d, abstract = {Thrainsdottir S, Malik RA, Rosén I, Jakobsson F, Bakhtadze E, Petersson J, Sundkvist G, Dahlin LB. Sural nerve biopsy may predict future nerve dysfunction. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2008.01118.x. (c) 2008 The Authors Journal compilation (c) 2008 Blackwell Munksgaard.Objective - Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysiological tests. The aim was to investigate progression of nerve dysfunction over time in relation to a baseline nerve biopsy. Methods - Baseline myelinated nerve fiber density (MNFD) was assessed in sural nerve biopsies from 10 men with type 2 diabetes, 10 with impaired and 10 with normal glucose tolerance. Nerve conduction and quantitative perception thresholds were estimated at baseline and follow-up (7-10 years later). Results - Subjects with low MNFD (</= 4700 fibers/mm(2)) showed decline of peroneal amplitude (P < 0.02) and conduction velocity (P < 0.04), as well as median nerve sensory amplitude (P < 0.05) and motor conduction velocity (P < 0.04) from baseline to follow-up. In linear regression analyses, diabetes influenced decline of nerve conduction. MNFD correlated negatively with body mass index (r = -0.469; P < 0.02). Conclusion - Low MNFD may predict progression of neurophysiological dysfunction and links obesity to myelinated nerve fiber loss.}, author = {Thrainsdottir, Soley and Malik, R A and Rosén, I and Jakobsson, F and Bakhtadze, Ekaterine and Petersson, Jesper and Sundkvist, Göran and Dahlin, L B}, issn = {1600-0404}, language = {eng}, pages = {38--46}, publisher = {Wiley-Blackwell}, series = {Acta Neurologica Scandinavica}, title = {Sural nerve biopsy may predict future nerve dysfunction.}, url = {http://dx.doi.org/10.1111/j.1600-0404.2008.01118.x}, volume = {120}, year = {2009}, }