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Sural nerve biopsy may predict future nerve dysfunction.

Thrainsdottir, Soley LU ; Malik, R A ; Rosén, I ; Jakobsson, F ; Bakhtadze, Ekaterine LU ; Petersson, Jesper LU ; Sundkvist, Göran LU and Dahlin, L B (2009) In Acta Neurologica Scandinavica 120. p.38-46
Abstract
Thrainsdottir S, Malik RA, Rosén I, Jakobsson F, Bakhtadze E, Petersson J, Sundkvist G, Dahlin LB. Sural nerve biopsy may predict future nerve dysfunction. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2008.01118.x. (c) 2008 The Authors Journal compilation (c) 2008 Blackwell Munksgaard.Objective - Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysiological tests. The aim was to investigate progression of nerve dysfunction over time in relation to a baseline nerve biopsy. Methods - Baseline myelinated nerve fiber density (MNFD) was assessed in sural nerve biopsies from 10 men with type 2 diabetes, 10 with impaired and 10 with normal glucose tolerance. Nerve conduction and quantitative... (More)
Thrainsdottir S, Malik RA, Rosén I, Jakobsson F, Bakhtadze E, Petersson J, Sundkvist G, Dahlin LB. Sural nerve biopsy may predict future nerve dysfunction. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2008.01118.x. (c) 2008 The Authors Journal compilation (c) 2008 Blackwell Munksgaard.Objective - Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysiological tests. The aim was to investigate progression of nerve dysfunction over time in relation to a baseline nerve biopsy. Methods - Baseline myelinated nerve fiber density (MNFD) was assessed in sural nerve biopsies from 10 men with type 2 diabetes, 10 with impaired and 10 with normal glucose tolerance. Nerve conduction and quantitative perception thresholds were estimated at baseline and follow-up (7-10 years later). Results - Subjects with low MNFD (</= 4700 fibers/mm(2)) showed decline of peroneal amplitude (P < 0.02) and conduction velocity (P < 0.04), as well as median nerve sensory amplitude (P < 0.05) and motor conduction velocity (P < 0.04) from baseline to follow-up. In linear regression analyses, diabetes influenced decline of nerve conduction. MNFD correlated negatively with body mass index (r = -0.469; P < 0.02). Conclusion - Low MNFD may predict progression of neurophysiological dysfunction and links obesity to myelinated nerve fiber loss. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Neurologica Scandinavica
volume
120
pages
38 - 46
publisher
Wiley-Blackwell
external identifiers
  • wos:000266686400005
  • pmid:19154542
  • scopus:66849104283
ISSN
1600-0404
DOI
10.1111/j.1600-0404.2008.01118.x
project
Diabetic neuropathy and nerve compression in diabetes
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diabetes Epidemiology and Neuropathy (013241560), Diabetes and Endocrinology (013241530), Neurology, Malmö (013027010)
id
d2dc7b75-7d04-499f-849f-986eecffd96d (old id 1289506)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19154542?dopt=Abstract
date added to LUP
2016-04-04 09:37:58
date last changed
2025-04-04 14:57:26
@article{d2dc7b75-7d04-499f-849f-986eecffd96d,
  abstract     = {{Thrainsdottir S, Malik RA, Rosén I, Jakobsson F, Bakhtadze E, Petersson J, Sundkvist G, Dahlin LB. Sural nerve biopsy may predict future nerve dysfunction. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2008.01118.x. (c) 2008 The Authors Journal compilation (c) 2008 Blackwell Munksgaard.Objective - Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysiological tests. The aim was to investigate progression of nerve dysfunction over time in relation to a baseline nerve biopsy. Methods - Baseline myelinated nerve fiber density (MNFD) was assessed in sural nerve biopsies from 10 men with type 2 diabetes, 10 with impaired and 10 with normal glucose tolerance. Nerve conduction and quantitative perception thresholds were estimated at baseline and follow-up (7-10 years later). Results - Subjects with low MNFD (&lt;/= 4700 fibers/mm(2)) showed decline of peroneal amplitude (P &lt; 0.02) and conduction velocity (P &lt; 0.04), as well as median nerve sensory amplitude (P &lt; 0.05) and motor conduction velocity (P &lt; 0.04) from baseline to follow-up. In linear regression analyses, diabetes influenced decline of nerve conduction. MNFD correlated negatively with body mass index (r = -0.469; P &lt; 0.02). Conclusion - Low MNFD may predict progression of neurophysiological dysfunction and links obesity to myelinated nerve fiber loss.}},
  author       = {{Thrainsdottir, Soley and Malik, R A and Rosén, I and Jakobsson, F and Bakhtadze, Ekaterine and Petersson, Jesper and Sundkvist, Göran and Dahlin, L B}},
  issn         = {{1600-0404}},
  language     = {{eng}},
  pages        = {{38--46}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Neurologica Scandinavica}},
  title        = {{Sural nerve biopsy may predict future nerve dysfunction.}},
  url          = {{http://dx.doi.org/10.1111/j.1600-0404.2008.01118.x}},
  doi          = {{10.1111/j.1600-0404.2008.01118.x}},
  volume       = {{120}},
  year         = {{2009}},
}