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Sex-Specific Associations of Circulating Uric Acid with Risk of Diabetes Incidence : A Population-Based Cohort Study from Sweden

Chen, Ning LU ; Muhammad, Iram Faqir LU ; Li, Zhibin ; Nilsson, Peter M LU and Borné, Yan LU (2020) In Diabetes, metabolic syndrome and obesity : targets and therapy 13. p.4323-4331
Abstract

Objective: To explore the longitudinal, as well as sex-specific, associations between circulating uric acid (UA) and diabetes incidence.

Methods: A cohort study of the Malmö Diet Cancer-cardiovascular Cohort (Malmö, Sweden) consisting of 3140 individuals without diabetes at baseline, was followed up until the end of 2018. Incident diabetes cases were identified by linking to local and national diabetes registers. Cox proportional hazard regression was used to assess plasma UA levels in relation to diabetes incidence with adjustment for established confounders.

Results: At baseline, with increasing levels of UA, subjects were more likely to be older and have significantly higher body mass index, waist circumference,... (More)

Objective: To explore the longitudinal, as well as sex-specific, associations between circulating uric acid (UA) and diabetes incidence.

Methods: A cohort study of the Malmö Diet Cancer-cardiovascular Cohort (Malmö, Sweden) consisting of 3140 individuals without diabetes at baseline, was followed up until the end of 2018. Incident diabetes cases were identified by linking to local and national diabetes registers. Cox proportional hazard regression was used to assess plasma UA levels in relation to diabetes incidence with adjustment for established confounders.

Results: At baseline, with increasing levels of UA, subjects were more likely to be older and have significantly higher body mass index, waist circumference, triglycerides, C-reactive protein, fasting glucose and 2-h plasma glucose postoral glucose tolerance test, and lower levels of high-density lipoprotein. During a mean follow-up period of 8.09±2.24 years, 315 (10.0%) participants developed diabetes, and diabetes incidence rates were 7.89, 9.48 and 18.11 per 1000 person-years for subjects in the 1st, 2nd, and 3rd tertiles of UA, respectively (log-rank test: p<0.001). With adjustment for potential confounders, elevated UA levels were significantly associated with increased risks of diabetes incidence, with the adjusted hazard ratio (HR) (95% confidence interval) for per standard deviation increment of UA of 1.22 (1.08-1.39, p=0.002). Compared with the 1st tertile of UA, the 3rd tertile showed significantly increased risk of diabetes incidence with the adjusted HR of 1.74 (1.24-2.45, p=0.002), and there was a significant trend between increasing tertiles of UA and diabetes incidence (trend test: p<0.001). Stratified analyses showed that elevated circulating UA levels were independently associated with increased risks of diabetes incidence in men but not in women, although the interaction between sex and UA was not statistically significant.

Conclusion: Elevated circulating UA was independently associated with increased risk of diabetes incidence, especially for men.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes, metabolic syndrome and obesity : targets and therapy
volume
13
pages
4323 - 4331
publisher
Dove Medical Press Ltd.
external identifiers
  • scopus:85132451044
  • pmid:33209045
ISSN
1178-7007
DOI
10.2147/DMSO.S273387
language
English
LU publication?
yes
id
d4ba1e6e-f21f-46e1-9a3d-b1f217770f1a
date added to LUP
2021-06-16 14:07:52
date last changed
2024-05-16 12:15:59
@article{d4ba1e6e-f21f-46e1-9a3d-b1f217770f1a,
  abstract     = {{<p>Objective: To explore the longitudinal, as well as sex-specific, associations between circulating uric acid (UA) and diabetes incidence.</p><p>Methods: A cohort study of the Malmö Diet Cancer-cardiovascular Cohort (Malmö, Sweden) consisting of 3140 individuals without diabetes at baseline, was followed up until the end of 2018. Incident diabetes cases were identified by linking to local and national diabetes registers. Cox proportional hazard regression was used to assess plasma UA levels in relation to diabetes incidence with adjustment for established confounders.</p><p>Results: At baseline, with increasing levels of UA, subjects were more likely to be older and have significantly higher body mass index, waist circumference, triglycerides, C-reactive protein, fasting glucose and 2-h plasma glucose postoral glucose tolerance test, and lower levels of high-density lipoprotein. During a mean follow-up period of 8.09±2.24 years, 315 (10.0%) participants developed diabetes, and diabetes incidence rates were 7.89, 9.48 and 18.11 per 1000 person-years for subjects in the 1st, 2nd, and 3rd tertiles of UA, respectively (log-rank test: p&lt;0.001). With adjustment for potential confounders, elevated UA levels were significantly associated with increased risks of diabetes incidence, with the adjusted hazard ratio (HR) (95% confidence interval) for per standard deviation increment of UA of 1.22 (1.08-1.39, p=0.002). Compared with the 1st tertile of UA, the 3rd tertile showed significantly increased risk of diabetes incidence with the adjusted HR of 1.74 (1.24-2.45, p=0.002), and there was a significant trend between increasing tertiles of UA and diabetes incidence (trend test: p&lt;0.001). Stratified analyses showed that elevated circulating UA levels were independently associated with increased risks of diabetes incidence in men but not in women, although the interaction between sex and UA was not statistically significant.</p><p>Conclusion: Elevated circulating UA was independently associated with increased risk of diabetes incidence, especially for men.</p>}},
  author       = {{Chen, Ning and Muhammad, Iram Faqir and Li, Zhibin and Nilsson, Peter M and Borné, Yan}},
  issn         = {{1178-7007}},
  language     = {{eng}},
  month        = {{11}},
  pages        = {{4323--4331}},
  publisher    = {{Dove Medical Press Ltd.}},
  series       = {{Diabetes, metabolic syndrome and obesity : targets and therapy}},
  title        = {{Sex-Specific Associations of Circulating Uric Acid with Risk of Diabetes Incidence : A Population-Based Cohort Study from Sweden}},
  url          = {{http://dx.doi.org/10.2147/DMSO.S273387}},
  doi          = {{10.2147/DMSO.S273387}},
  volume       = {{13}},
  year         = {{2020}},
}