Sex-Specific Associations of Circulating Uric Acid with Risk of Diabetes Incidence : A Population-Based Cohort Study from Sweden
(2020) In Diabetes, metabolic syndrome and obesity : targets and therapy 13. p.4323-4331- Abstract
Objective: To explore the longitudinal, as well as sex-specific, associations between circulating uric acid (UA) and diabetes incidence.
Methods: A cohort study of the Malmö Diet Cancer-cardiovascular Cohort (Malmö, Sweden) consisting of 3140 individuals without diabetes at baseline, was followed up until the end of 2018. Incident diabetes cases were identified by linking to local and national diabetes registers. Cox proportional hazard regression was used to assess plasma UA levels in relation to diabetes incidence with adjustment for established confounders.
Results: At baseline, with increasing levels of UA, subjects were more likely to be older and have significantly higher body mass index, waist circumference,... (More)
Objective: To explore the longitudinal, as well as sex-specific, associations between circulating uric acid (UA) and diabetes incidence.
Methods: A cohort study of the Malmö Diet Cancer-cardiovascular Cohort (Malmö, Sweden) consisting of 3140 individuals without diabetes at baseline, was followed up until the end of 2018. Incident diabetes cases were identified by linking to local and national diabetes registers. Cox proportional hazard regression was used to assess plasma UA levels in relation to diabetes incidence with adjustment for established confounders.
Results: At baseline, with increasing levels of UA, subjects were more likely to be older and have significantly higher body mass index, waist circumference, triglycerides, C-reactive protein, fasting glucose and 2-h plasma glucose postoral glucose tolerance test, and lower levels of high-density lipoprotein. During a mean follow-up period of 8.09±2.24 years, 315 (10.0%) participants developed diabetes, and diabetes incidence rates were 7.89, 9.48 and 18.11 per 1000 person-years for subjects in the 1st, 2nd, and 3rd tertiles of UA, respectively (log-rank test: p<0.001). With adjustment for potential confounders, elevated UA levels were significantly associated with increased risks of diabetes incidence, with the adjusted hazard ratio (HR) (95% confidence interval) for per standard deviation increment of UA of 1.22 (1.08-1.39, p=0.002). Compared with the 1st tertile of UA, the 3rd tertile showed significantly increased risk of diabetes incidence with the adjusted HR of 1.74 (1.24-2.45, p=0.002), and there was a significant trend between increasing tertiles of UA and diabetes incidence (trend test: p<0.001). Stratified analyses showed that elevated circulating UA levels were independently associated with increased risks of diabetes incidence in men but not in women, although the interaction between sex and UA was not statistically significant.
Conclusion: Elevated circulating UA was independently associated with increased risk of diabetes incidence, especially for men.
(Less)
- author
- Chen, Ning LU ; Muhammad, Iram Faqir LU ; Li, Zhibin ; Nilsson, Peter M LU and Borné, Yan LU
- organization
-
- Diabetes - Islet Patophysiology (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- Cardiovascular Research - Epidemiology (research group)
- Internal Medicine - Epidemiology (research group)
- EpiHealth: Epidemiology for Health
- Ophthalmology (Malmö) (research group)
- Nutrition Epidemiology (research group)
- publishing date
- 2020-11-12
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes, metabolic syndrome and obesity : targets and therapy
- volume
- 13
- pages
- 4323 - 4331
- publisher
- Dove Medical Press Ltd.
- external identifiers
-
- pmid:33209045
- scopus:85132451044
- ISSN
- 1178-7007
- DOI
- 10.2147/DMSO.S273387
- language
- English
- LU publication?
- yes
- id
- d4ba1e6e-f21f-46e1-9a3d-b1f217770f1a
- date added to LUP
- 2021-06-16 14:07:52
- date last changed
- 2024-07-25 19:23:53
@article{d4ba1e6e-f21f-46e1-9a3d-b1f217770f1a, abstract = {{<p>Objective: To explore the longitudinal, as well as sex-specific, associations between circulating uric acid (UA) and diabetes incidence.</p><p>Methods: A cohort study of the Malmö Diet Cancer-cardiovascular Cohort (Malmö, Sweden) consisting of 3140 individuals without diabetes at baseline, was followed up until the end of 2018. Incident diabetes cases were identified by linking to local and national diabetes registers. Cox proportional hazard regression was used to assess plasma UA levels in relation to diabetes incidence with adjustment for established confounders.</p><p>Results: At baseline, with increasing levels of UA, subjects were more likely to be older and have significantly higher body mass index, waist circumference, triglycerides, C-reactive protein, fasting glucose and 2-h plasma glucose postoral glucose tolerance test, and lower levels of high-density lipoprotein. During a mean follow-up period of 8.09±2.24 years, 315 (10.0%) participants developed diabetes, and diabetes incidence rates were 7.89, 9.48 and 18.11 per 1000 person-years for subjects in the 1st, 2nd, and 3rd tertiles of UA, respectively (log-rank test: p<0.001). With adjustment for potential confounders, elevated UA levels were significantly associated with increased risks of diabetes incidence, with the adjusted hazard ratio (HR) (95% confidence interval) for per standard deviation increment of UA of 1.22 (1.08-1.39, p=0.002). Compared with the 1st tertile of UA, the 3rd tertile showed significantly increased risk of diabetes incidence with the adjusted HR of 1.74 (1.24-2.45, p=0.002), and there was a significant trend between increasing tertiles of UA and diabetes incidence (trend test: p<0.001). Stratified analyses showed that elevated circulating UA levels were independently associated with increased risks of diabetes incidence in men but not in women, although the interaction between sex and UA was not statistically significant.</p><p>Conclusion: Elevated circulating UA was independently associated with increased risk of diabetes incidence, especially for men.</p>}}, author = {{Chen, Ning and Muhammad, Iram Faqir and Li, Zhibin and Nilsson, Peter M and Borné, Yan}}, issn = {{1178-7007}}, language = {{eng}}, month = {{11}}, pages = {{4323--4331}}, publisher = {{Dove Medical Press Ltd.}}, series = {{Diabetes, metabolic syndrome and obesity : targets and therapy}}, title = {{Sex-Specific Associations of Circulating Uric Acid with Risk of Diabetes Incidence : A Population-Based Cohort Study from Sweden}}, url = {{http://dx.doi.org/10.2147/DMSO.S273387}}, doi = {{10.2147/DMSO.S273387}}, volume = {{13}}, year = {{2020}}, }