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Patient Outcomes after Heart Transplantation in Sweden between 1988 and 2017 : Continuous Improvement in Survival

Esmaily, S. ; Dellgren, G. ; Bobbio, E. ; Nilsson, J. LU orcid ; Rådegran, G. LU ; Braun, O. LU ; Gjesdal, G. LU ; Löfman, I. ; Melin, M. and Karason, K. (2020) In The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 39(4). p.284-284
Abstract

PURPOSE: To investigate the survival of heart transplant (HTx) recipients during different time periods in Sweden. We hypothesized that the survival for HTx recipients has improved following advancements in the management of these patients. METHODS: Data was obtained through the database of the organ exchange organization Scandiatransplant. All patients who underwent HTx in Sweden between Jan 1988 and Dec 2017 were included. Patients were divided into five cohorts of six-year periods each. RESULTS: A total of 1137 HTx recipients were included. Main causes of transplantation were dilated cardiomyopathy (44 %) and ischemic heart disease (18 %). Retransplantation constituted a small portion of the overall total (2 %). The cohorts were... (More)

PURPOSE: To investigate the survival of heart transplant (HTx) recipients during different time periods in Sweden. We hypothesized that the survival for HTx recipients has improved following advancements in the management of these patients. METHODS: Data was obtained through the database of the organ exchange organization Scandiatransplant. All patients who underwent HTx in Sweden between Jan 1988 and Dec 2017 were included. Patients were divided into five cohorts of six-year periods each. RESULTS: A total of 1137 HTx recipients were included. Main causes of transplantation were dilated cardiomyopathy (44 %) and ischemic heart disease (18 %). Retransplantation constituted a small portion of the overall total (2 %). The cohorts were similar in terms of age and gender, while later cohorts had higher BMI, lower GFR and longer ischemia time (Tab. 1). The later cohorts received organs from older donors (Tab. 1). The amount of heart transplantations performed in Sweden has increased with time (Tab. 1). Log-rank test comparing the survival curves was able to show improved survival during later eras (Fig. 1). CONCLUSION: Survival among HTx recipients has significantly improved in Sweden over time, despite less favorable recipients and donor characteristics. This was related to both reduced postoperative mortality and also improved long-time survival.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
volume
39
issue
4
pages
1 pages
publisher
Elsevier
external identifiers
  • pmid:32465295
  • scopus:85085635681
ISSN
1557-3117
DOI
10.1016/j.healun.2020.01.626
language
English
LU publication?
yes
id
d623b7e5-0215-4152-9658-a16b2085ac61
date added to LUP
2020-06-24 14:29:50
date last changed
2021-05-11 02:57:10
@misc{d623b7e5-0215-4152-9658-a16b2085ac61,
  abstract     = {{<p>PURPOSE: To investigate the survival of heart transplant (HTx) recipients during different time periods in Sweden. We hypothesized that the survival for HTx recipients has improved following advancements in the management of these patients. METHODS: Data was obtained through the database of the organ exchange organization Scandiatransplant. All patients who underwent HTx in Sweden between Jan 1988 and Dec 2017 were included. Patients were divided into five cohorts of six-year periods each. RESULTS: A total of 1137 HTx recipients were included. Main causes of transplantation were dilated cardiomyopathy (44 %) and ischemic heart disease (18 %). Retransplantation constituted a small portion of the overall total (2 %). The cohorts were similar in terms of age and gender, while later cohorts had higher BMI, lower GFR and longer ischemia time (Tab. 1). The later cohorts received organs from older donors (Tab. 1). The amount of heart transplantations performed in Sweden has increased with time (Tab. 1). Log-rank test comparing the survival curves was able to show improved survival during later eras (Fig. 1). CONCLUSION: Survival among HTx recipients has significantly improved in Sweden over time, despite less favorable recipients and donor characteristics. This was related to both reduced postoperative mortality and also improved long-time survival.</p>}},
  author       = {{Esmaily, S. and Dellgren, G. and Bobbio, E. and Nilsson, J. and Rådegran, G. and Braun, O. and Gjesdal, G. and Löfman, I. and Melin, M. and Karason, K.}},
  issn         = {{1557-3117}},
  language     = {{eng}},
  note         = {{Conference Abstract}},
  number       = {{4}},
  pages        = {{284--284}},
  publisher    = {{Elsevier}},
  series       = {{The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation}},
  title        = {{Patient Outcomes after Heart Transplantation in Sweden between 1988 and 2017 : Continuous Improvement in Survival}},
  url          = {{http://dx.doi.org/10.1016/j.healun.2020.01.626}},
  doi          = {{10.1016/j.healun.2020.01.626}},
  volume       = {{39}},
  year         = {{2020}},
}