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Premature ovarian failure after childhood cancer and risk of metabolic syndrome : A cross-sectional analysis

Netterlid, Axel LU ; Mörse, Helena LU ; Giwercman, Aleksander LU ; Henic, Emir LU ; Åkesson, Kristina E. LU ; Erfurth, Eva Marie LU and Elfving, Maria LU (2021) In European Journal of Endocrinology 185(1). p.67-75
Abstract

Objective: Female childhood cancer survivors (CCS) are at risk of several late effects, such as metabolic syndrome (MetS) and premature ovarian insufficiency (POI). The objective is to study if POI is associated with risk of MetS and increased cardiovascular risk in CSS. Design: A cross-sectional study with a median time since the cancer diagnosis of 25 (12-41) years. Patients and controls were recruited from the South Medical Region of Sweden. Methods: The study included 167 female CCS, median age 34 (19-57) years, diagnosed with childhood cancer at median age 8.4 (0.1-17.9) years together with 164 controls, matched for age, sex, ethnicity, residence, and smoking habits. All subjects were examined with fasting glucose, insulin, HbA1c,... (More)

Objective: Female childhood cancer survivors (CCS) are at risk of several late effects, such as metabolic syndrome (MetS) and premature ovarian insufficiency (POI). The objective is to study if POI is associated with risk of MetS and increased cardiovascular risk in CSS. Design: A cross-sectional study with a median time since the cancer diagnosis of 25 (12-41) years. Patients and controls were recruited from the South Medical Region of Sweden. Methods: The study included 167 female CCS, median age 34 (19-57) years, diagnosed with childhood cancer at median age 8.4 (0.1-17.9) years together with 164 controls, matched for age, sex, ethnicity, residence, and smoking habits. All subjects were examined with fasting glucose, insulin, HbA1c, and lipid profile. Fat mass was calculated with dual-energy X-ray absorptiometry (DXA), and questionnaires for medication were obtained. Detailed information of cancer treatment was available. Results: POI was present in 13% (22/167) among CCS (hypothalamic/pituitary cause excluded) and in none among controls. MetS was present in 14% (24/167) among all CCS (P = 0.001), in 23% (5/22) of those with POI (P < 0.001), compared with 4% (6/164) among controls. OR for MetS in all CCS compared with controls was 4.4 (95% CI: 1.8, 11.1) (P = 0.002) and among CCS with POI the OR was 7.7 (CI: 2.1, 28.1) (P = 0.002). Conclusion: The prevalence of MetS was higher in females treated for childhood cancer compared with controls, and the presence of POI significantly increased the risk of developing MetS.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Endocrinology
volume
185
issue
1
pages
9 pages
publisher
Society of the European Journal of Endocrinology
external identifiers
  • pmid:33914702
  • scopus:85107088311
ISSN
0804-4643
DOI
10.1530/EJE-20-1275
language
English
LU publication?
yes
id
d624ea9b-1627-499b-944c-1229f8502a3d
date added to LUP
2021-06-23 15:04:52
date last changed
2024-06-15 12:51:07
@article{d624ea9b-1627-499b-944c-1229f8502a3d,
  abstract     = {{<p>Objective: Female childhood cancer survivors (CCS) are at risk of several late effects, such as metabolic syndrome (MetS) and premature ovarian insufficiency (POI). The objective is to study if POI is associated with risk of MetS and increased cardiovascular risk in CSS. Design: A cross-sectional study with a median time since the cancer diagnosis of 25 (12-41) years. Patients and controls were recruited from the South Medical Region of Sweden. Methods: The study included 167 female CCS, median age 34 (19-57) years, diagnosed with childhood cancer at median age 8.4 (0.1-17.9) years together with 164 controls, matched for age, sex, ethnicity, residence, and smoking habits. All subjects were examined with fasting glucose, insulin, HbA1c, and lipid profile. Fat mass was calculated with dual-energy X-ray absorptiometry (DXA), and questionnaires for medication were obtained. Detailed information of cancer treatment was available. Results: POI was present in 13% (22/167) among CCS (hypothalamic/pituitary cause excluded) and in none among controls. MetS was present in 14% (24/167) among all CCS (P = 0.001), in 23% (5/22) of those with POI (P &lt; 0.001), compared with 4% (6/164) among controls. OR for MetS in all CCS compared with controls was 4.4 (95% CI: 1.8, 11.1) (P = 0.002) and among CCS with POI the OR was 7.7 (CI: 2.1, 28.1) (P = 0.002). Conclusion: The prevalence of MetS was higher in females treated for childhood cancer compared with controls, and the presence of POI significantly increased the risk of developing MetS.</p>}},
  author       = {{Netterlid, Axel and Mörse, Helena and Giwercman, Aleksander and Henic, Emir and Åkesson, Kristina E. and Erfurth, Eva Marie and Elfving, Maria}},
  issn         = {{0804-4643}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{67--75}},
  publisher    = {{Society of the European Journal of Endocrinology}},
  series       = {{European Journal of Endocrinology}},
  title        = {{Premature ovarian failure after childhood cancer and risk of metabolic syndrome : A cross-sectional analysis}},
  url          = {{http://dx.doi.org/10.1530/EJE-20-1275}},
  doi          = {{10.1530/EJE-20-1275}},
  volume       = {{185}},
  year         = {{2021}},
}