Inflammation at birth and the insulin-like growth factor system in very preterm infants.
Pupp, Ingrid LU
; Hellström-Westas, Lena
LU
; Cilio, Corrado
LU
; Andersson, S
; Fellman, Vineta
LU
and Ley, David
LU
(2007)
In Acta Pædiatrica
96(6).
p.830-836
- Abstract
- Background: Foetal inflammation is associated with an increased risk of brain damage in preterm infants whereas IGF-I is essential for cerebral development and exhibits anti-apoptotic properties. Aim: To assess levels of IGF-I and IGF binding proteins at very preterm birth and to evaluate their relationship with foetal pro-inflammation and cerebral damage. Methods: Levels of IGF-I, IGF binding protein 3 (IGFBP-3), high- (hp) and low-phosphorylated (lp) IGFBP-1 in cord blood and neonatal blood at 72 h after delivery were analysed in relation to levels of cytokines and cerebral damage as detected by ultrasound in 74 inborn infants [mean gestational age (GA) 27.1 weeks]. Evaluation was performed separately according to birth weight for GA.... (More)
- Background: Foetal inflammation is associated with an increased risk of brain damage in preterm infants whereas IGF-I is essential for cerebral development and exhibits anti-apoptotic properties. Aim: To assess levels of IGF-I and IGF binding proteins at very preterm birth and to evaluate their relationship with foetal pro-inflammation and cerebral damage. Methods: Levels of IGF-I, IGF binding protein 3 (IGFBP-3), high- (hp) and low-phosphorylated (lp) IGFBP-1 in cord blood and neonatal blood at 72 h after delivery were analysed in relation to levels of cytokines and cerebral damage as detected by ultrasound in 74 inborn infants [mean gestational age (GA) 27.1 weeks]. Evaluation was performed separately according to birth weight for GA. Results: In cord blood of infants appropriate for gestational age (AGA) higher levels of IL-6 and IL-8 were associated with lower IGF-I (r = -0.38, p = 0.008 and r = -0.36, p = 0.014). Higher levels of IL-6, IL-8 and TNF-alpha were associated with both higher levels of lpIGFBP-1 (r = 0.54, p < 0.001, r = 0.50, p < 0.001 and r = 0.13, p = 0.012, respectively) and hpIGFBP-1 (r = 0.55, p < 0.001, r = 0.45, p = 0.002 and r = 0.32, p = 0.026, respectively). Infants with intraventricular haemorrhage grade III (n = 5) had higher levels of lp/hpIGFBP-1 in cord blood (p = 0.001 and 0.002, respectively). Conclusion: Pro-inflammation at birth is associated with changes in the IGF-system. This may be of importance for development of brain damage in preterm infants. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/167319
- author
- Pupp, Ingrid
LU
; Hellström-Westas, Lena
LU
; Cilio, Corrado
LU
; Andersson, S
; Fellman, Vineta
LU
and Ley, David
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- foetal inflammation, insulin-like growth factor, brain damage, cytokine, I, preterm
- in
- Acta Pædiatrica
- volume
- 96
- issue
- 6
- pages
- 830 - 836
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000246789600012
- scopus:34249818501
- ISSN
- 1651-2227
- DOI
- 10.1111/j.1651-2227.2007.00276.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Paediatrics (Lund) (013002000), Pediatrics/Urology/Gynecology/Endocrinology (013240400), Cellular Autoimmunity Unit (013241520)
- id
- d62799fb-662d-4daa-8a77-9ef1cfa7010a (old id 167319)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17465986&dopt=Abstract
- date added to LUP
- 2016-04-01 16:39:36
- date last changed
- 2023-09-18 22:32:59
@article{d62799fb-662d-4daa-8a77-9ef1cfa7010a,
abstract = {{Background: Foetal inflammation is associated with an increased risk of brain damage in preterm infants whereas IGF-I is essential for cerebral development and exhibits anti-apoptotic properties. Aim: To assess levels of IGF-I and IGF binding proteins at very preterm birth and to evaluate their relationship with foetal pro-inflammation and cerebral damage. Methods: Levels of IGF-I, IGF binding protein 3 (IGFBP-3), high- (hp) and low-phosphorylated (lp) IGFBP-1 in cord blood and neonatal blood at 72 h after delivery were analysed in relation to levels of cytokines and cerebral damage as detected by ultrasound in 74 inborn infants [mean gestational age (GA) 27.1 weeks]. Evaluation was performed separately according to birth weight for GA. Results: In cord blood of infants appropriate for gestational age (AGA) higher levels of IL-6 and IL-8 were associated with lower IGF-I (r = -0.38, p = 0.008 and r = -0.36, p = 0.014). Higher levels of IL-6, IL-8 and TNF-alpha were associated with both higher levels of lpIGFBP-1 (r = 0.54, p < 0.001, r = 0.50, p < 0.001 and r = 0.13, p = 0.012, respectively) and hpIGFBP-1 (r = 0.55, p < 0.001, r = 0.45, p = 0.002 and r = 0.32, p = 0.026, respectively). Infants with intraventricular haemorrhage grade III (n = 5) had higher levels of lp/hpIGFBP-1 in cord blood (p = 0.001 and 0.002, respectively). Conclusion: Pro-inflammation at birth is associated with changes in the IGF-system. This may be of importance for development of brain damage in preterm infants.}},
author = {{Pupp, Ingrid and Hellström-Westas, Lena and Cilio, Corrado and Andersson, S and Fellman, Vineta and Ley, David}},
issn = {{1651-2227}},
keywords = {{foetal inflammation; insulin-like growth factor; brain damage; cytokine; I; preterm}},
language = {{eng}},
number = {{6}},
pages = {{830--836}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Pædiatrica}},
title = {{Inflammation at birth and the insulin-like growth factor system in very preterm infants.}},
url = {{http://dx.doi.org/10.1111/j.1651-2227.2007.00276.x}},
doi = {{10.1111/j.1651-2227.2007.00276.x}},
volume = {{96}},
year = {{2007}},
}