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Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility

Sud, Amit; Thomsen, Hauke; Law, Philip J; Försti, Asta LU ; Filho, Miguel Inacio da Silva; Holroyd, Amy; Broderick, Peter; Orlando, Giulia; Lenive, Oleg and Wright, Lauren, et al. (2017) In Nature Communications 8(1). p.1892-1892
Abstract

Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10-8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10-17), 6q23.3 (rs6928977, P = 4.62 × 10-11), 10p14 (rs3781093, P = 9.49 × 10-13), 13q34 (rs112998813, P = 4.58 × 10-8) and 16p13.13 (rs34972832, P = 2.12 × 10-8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma... (More)

Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10-8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10-17), 6q23.3 (rs6928977, P = 4.62 × 10-11), 10p14 (rs3781093, P = 9.49 × 10-13), 13q34 (rs112998813, P = 4.58 × 10-8) and 16p13.13 (rs34972832, P = 2.12 × 10-8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.

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@article{d738d593-88ec-4327-938c-72c310017491,
  abstract     = {<p>Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10-8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10-17), 6q23.3 (rs6928977, P = 4.62 × 10-11), 10p14 (rs3781093, P = 9.49 × 10-13), 13q34 (rs112998813, P = 4.58 × 10-8) and 16p13.13 (rs34972832, P = 2.12 × 10-8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.</p>},
  author       = {Sud, Amit and Thomsen, Hauke and Law, Philip J and Försti, Asta and Filho, Miguel Inacio da Silva and Holroyd, Amy and Broderick, Peter and Orlando, Giulia and Lenive, Oleg and Wright, Lauren and Cooke, Rosie and Easton, Douglas and Pharoah, Paul and Dunning, Alison and Peto, Julian and Canzian, Federico and Eeles, Rosalind and Kote-Jarai, ZSofia and Muir, Kenneth and Pashayan, Nora and Hoffmann, Per and Nöthen, Markus M and Jöckel, Karl-Heinz and Strandmann, Elke Pogge von and Lightfoot, Tracy and Kane, Eleanor and Roman, Eve and Lake, Annette and Montgomery, Dorothy and Jarrett, Ruth F and Swerdlow, Anthony J and Engert, Andreas and Orr, Nick and Hemminki, Kari and Houlston, Richard S and , },
  issn         = {2041-1723},
  keyword      = {Journal Article},
  language     = {eng},
  month        = {12},
  number       = {1},
  pages        = {1892--1892},
  publisher    = {Nature Publishing Group},
  series       = {Nature Communications},
  title        = {Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility},
  url          = {http://dx.doi.org/10.1038/s41467-017-00320-1},
  volume       = {8},
  year         = {2017},
}