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Complex regional pain syndrome and use of psychotropic drugs as a proxy for psychological health

Dahlin, Lars B. LU orcid ; Perez, Raquel LU orcid ; Nyman, Erika LU ; Zimmerman, Malin LU orcid and Merlo, Juan LU orcid (2025) In Scientific Reports 15(1).
Abstract

We aimed to investigate the association between psychotropic drug use (proxy for psychological health) and Complex Regional Pain Syndrome (CRPS) type 1 and type 2 in upper and lower limbs. We also assessed the impact of demographic and socioeconomic factors. From a national record linkage database [4,706,821 individuals (25–64 years); CRPS type 1 = 809; type 2 = 225], prevalence ratios (PR), absolute risk (AR), and AR difference (ARD) [95% confidence intervals (CI)] were estimated by logistic and Cox regressions with constant time at risk. About 36% of CRPS individuals consumed psychotropic drugs (reference: general population 15%). Unadjusted PRs were two times higher in nerve injuries/disorders without CRPS [PR = 1.78; 95% CI:... (More)

We aimed to investigate the association between psychotropic drug use (proxy for psychological health) and Complex Regional Pain Syndrome (CRPS) type 1 and type 2 in upper and lower limbs. We also assessed the impact of demographic and socioeconomic factors. From a national record linkage database [4,706,821 individuals (25–64 years); CRPS type 1 = 809; type 2 = 225], prevalence ratios (PR), absolute risk (AR), and AR difference (ARD) [95% confidence intervals (CI)] were estimated by logistic and Cox regressions with constant time at risk. About 36% of CRPS individuals consumed psychotropic drugs (reference: general population 15%). Unadjusted PRs were two times higher in nerve injuries/disorders without CRPS [PR = 1.78; 95% CI: 1.73–1.82] and CRPS type 1 [2.33 (2.07–2.62)] and almost three times higher in CRPS type 2 [2.79 (2.27–3.42)]. Higher ARDs were observed in type 2, independent of level of income, and were higher for the high-income category. In type 2, ARDs were higher for middle-high/high occupational status levels. Higher ARDs were observed in nerve injuries/nerve disorders, CRPS type 1, and type 2 in immigrants, especially high for type 2. Regarding most age intervals, ARDs were higher for individuals with CRPS type 2. Individuals with CRPS, especially type 2, have high risk of impaired psychological health.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
15
issue
1
article number
24963
publisher
Nature Publishing Group
external identifiers
  • scopus:105010434524
  • pmid:40640245
ISSN
2045-2322
DOI
10.1038/s41598-025-09701-9
language
English
LU publication?
yes
id
d7430155-cad2-4c33-9e8a-b9a7f3de1eca
date added to LUP
2025-10-23 09:47:09
date last changed
2025-10-23 09:48:26
@article{d7430155-cad2-4c33-9e8a-b9a7f3de1eca,
  abstract     = {{<p>We aimed to investigate the association between psychotropic drug use (proxy for psychological health) and Complex Regional Pain Syndrome (CRPS) type 1 and type 2 in upper and lower limbs. We also assessed the impact of demographic and socioeconomic factors. From a national record linkage database [4,706,821 individuals (25–64 years); CRPS type 1 = 809; type 2 = 225], prevalence ratios (PR), absolute risk (AR), and AR difference (ARD) [95% confidence intervals (CI)] were estimated by logistic and Cox regressions with constant time at risk. About 36% of CRPS individuals consumed psychotropic drugs (reference: general population 15%). Unadjusted PRs were two times higher in nerve injuries/disorders without CRPS [PR = 1.78; 95% CI: 1.73–1.82] and CRPS type 1 [2.33 (2.07–2.62)] and almost three times higher in CRPS type 2 [2.79 (2.27–3.42)]. Higher ARDs were observed in type 2, independent of level of income, and were higher for the high-income category. In type 2, ARDs were higher for middle-high/high occupational status levels. Higher ARDs were observed in nerve injuries/nerve disorders, CRPS type 1, and type 2 in immigrants, especially high for type 2. Regarding most age intervals, ARDs were higher for individuals with CRPS type 2. Individuals with CRPS, especially type 2, have high risk of impaired psychological health.</p>}},
  author       = {{Dahlin, Lars B. and Perez, Raquel and Nyman, Erika and Zimmerman, Malin and Merlo, Juan}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Complex regional pain syndrome and use of psychotropic drugs as a proxy for psychological health}},
  url          = {{http://dx.doi.org/10.1038/s41598-025-09701-9}},
  doi          = {{10.1038/s41598-025-09701-9}},
  volume       = {{15}},
  year         = {{2025}},
}