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Immunoheterogeneity of parathyroid hormone after surgery for primary hyperparathyroidism

Bergenfelz, A LU ; Valdermarsson, S and Ahrén, B LU (1994) In Clinica Chimica Acta 231(2). p.45-139
Abstract

Circulating parathyroid hormone (PTH) immunoheterogeneity is altered in primary hyperparathyroidism (pHPT). It is not known, however, whether the relative secretion of various PTH fragments differs between the adenomatous and the non-adenomatous glands in pHPT. We therefore examined the immunoheterogeneity of PTH in patients operated upon because of parathyroid adenoma pre- and 4 days postoperatively during an EDTA-infusion test. Following surgery, baseline levels of amino-terminal PTH (N-PTH) were reduced by a smaller degree than the levels of intact PTH (i-PTH) (P < 0.05) resulting in a higher N/i ratio postoperatively (P < 0.05). Furthermore, the increase in i-PTH and C-PTH fragments during the EDTA infusion test was lower... (More)

Circulating parathyroid hormone (PTH) immunoheterogeneity is altered in primary hyperparathyroidism (pHPT). It is not known, however, whether the relative secretion of various PTH fragments differs between the adenomatous and the non-adenomatous glands in pHPT. We therefore examined the immunoheterogeneity of PTH in patients operated upon because of parathyroid adenoma pre- and 4 days postoperatively during an EDTA-infusion test. Following surgery, baseline levels of amino-terminal PTH (N-PTH) were reduced by a smaller degree than the levels of intact PTH (i-PTH) (P < 0.05) resulting in a higher N/i ratio postoperatively (P < 0.05). Furthermore, the increase in i-PTH and C-PTH fragments during the EDTA infusion test was lower postoperatively than preoperatively (P < 0.05), whereas the increase in N-PTH did not differ. The results therefore suggest that compared with the parathyroid adenoma, the non-adenomatous glands secrete relatively more N-terminal PTH.

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organization
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Contribution to journal
publication status
published
keywords
Adult, Antibodies, Calcium, Edetic Acid, Humans, Hyperparathyroidism, Hypocalcemia, Middle Aged, Parathyroid Hormone, Peptide Fragments, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
in
Clinica Chimica Acta
volume
231
issue
2
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:0027942610
ISSN
0009-8981
language
English
LU publication?
yes
id
d794bd48-6d1f-4f19-ba8a-9c926fba0f47
date added to LUP
2017-05-10 17:42:52
date last changed
2017-09-08 15:51:57
@article{d794bd48-6d1f-4f19-ba8a-9c926fba0f47,
  abstract     = {<p>Circulating parathyroid hormone (PTH) immunoheterogeneity is altered in primary hyperparathyroidism (pHPT). It is not known, however, whether the relative secretion of various PTH fragments differs between the adenomatous and the non-adenomatous glands in pHPT. We therefore examined the immunoheterogeneity of PTH in patients operated upon because of parathyroid adenoma pre- and 4 days postoperatively during an EDTA-infusion test. Following surgery, baseline levels of amino-terminal PTH (N-PTH) were reduced by a smaller degree than the levels of intact PTH (i-PTH) (P &lt; 0.05) resulting in a higher N/i ratio postoperatively (P &lt; 0.05). Furthermore, the increase in i-PTH and C-PTH fragments during the EDTA infusion test was lower postoperatively than preoperatively (P &lt; 0.05), whereas the increase in N-PTH did not differ. The results therefore suggest that compared with the parathyroid adenoma, the non-adenomatous glands secrete relatively more N-terminal PTH.</p>},
  author       = {Bergenfelz, A and Valdermarsson, S and Ahrén, B},
  issn         = {0009-8981},
  keyword      = {Adult,Antibodies,Calcium,Edetic Acid,Humans,Hyperparathyroidism,Hypocalcemia,Middle Aged,Parathyroid Hormone,Peptide Fragments,Comparative Study,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {12},
  number       = {2},
  pages        = {45--139},
  publisher    = {Elsevier},
  series       = {Clinica Chimica Acta},
  title        = {Immunoheterogeneity of parathyroid hormone after surgery for primary hyperparathyroidism},
  volume       = {231},
  year         = {1994},
}