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Survival of rats with N29 brain tumours after irradiation with 5 or 15 Gy and immunization with IFN-gamma secreting tumour cells

Persson, Bertil R LU orcid ; Baureus Koch, Catrin LU ; Grafström, Gustav LU ; Ceberg, Crister LU orcid ; Munck af Rosenschöld, Per LU orcid ; Widegren, Bengt LU and Salford, Leif LU (2008) 1st International Conference on Biomedical Engineering and Informatics In BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008 2. p.243-247
Abstract
Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p < 0.05)... (More)
Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p < 0.05) increased survival for the tumour bearing rats. Corresponding combination with 15 Gy RT resulted in 50% complete remissions. There is a possibility of a synergistic effect by optimal combination of radiation therapy and immunization. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
BioMedical Engineering and Informatics : New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008 - New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
series title
BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
volume
2
article number
4549171
pages
243 - 247
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
conference name
1st International Conference on Biomedical Engineering and Informatics
conference location
Sanya, China
conference dates
2008-05-27 - 2008-05-30
external identifiers
  • wos:000257001500048
  • scopus:51649122272
ISBN
9780769531182
DOI
10.1109/BMEI.2008.345
language
English
LU publication?
yes
id
d7a364b9-4489-4668-973e-83e0ff2e97d8 (old id 1406835)
date added to LUP
2016-04-04 12:12:37
date last changed
2023-07-20 09:41:20
@inproceedings{d7a364b9-4489-4668-973e-83e0ff2e97d8,
  abstract     = {{Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p &lt; 0.05) increased survival for the tumour bearing rats. Corresponding combination with 15 Gy RT resulted in 50% complete remissions. There is a possibility of a synergistic effect by optimal combination of radiation therapy and immunization.}},
  author       = {{Persson, Bertil R and Baureus Koch, Catrin and Grafström, Gustav and Ceberg, Crister and Munck af Rosenschöld, Per and Widegren, Bengt and Salford, Leif}},
  booktitle    = {{BioMedical Engineering and Informatics : New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008}},
  isbn         = {{9780769531182}},
  language     = {{eng}},
  pages        = {{243--247}},
  publisher    = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
  series       = {{BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008}},
  title        = {{Survival of rats with N29 brain tumours after irradiation with 5 or 15 Gy and immunization with IFN-gamma secreting tumour cells}},
  url          = {{http://dx.doi.org/10.1109/BMEI.2008.345}},
  doi          = {{10.1109/BMEI.2008.345}},
  volume       = {{2}},
  year         = {{2008}},
}