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Short-term lingonberry feeding is associated with decreased insulin levels and altered adipose tissue function in high-fat diet fed C57BL/6J mice

Kotowska, Dorota LU ; Neuhaus, Mathis LU orcid ; Heyman-Lindén, Lovisa ; Morén, Björn LU orcid ; Li, Shuyi LU ; Kryvokhyzha, Dmytro LU ; Berger, Karin LU orcid and Stenkula, Karin G. LU (2022) In Journal of Functional Foods 94. p.1-8
Abstract

Intact adipose tissue function is essential to maintain glucose and lipid homeostasis. To study the impact of altered adipose tissue function on whole-body metabolism, diet-induced obesity in mice is frequently used as a model organism. In the current study, we have examined health-promoting effects of a lingonberry supplemented diet. We found C57BL/6J mice fed a high-fat diet supplemented with lingonberry for 4 days to have significantly lowered body-weight gain, adipose tissue expansion, and reduced insulin levels, compared to mice fed an isocaloric high-fat diet. RNA-Seq analysis of epididymal adipose tissue revealed differential expression of genes related to mitochondria fission (Mief1, Dnm1, Vps35, and Opa1). Further, we detected... (More)

Intact adipose tissue function is essential to maintain glucose and lipid homeostasis. To study the impact of altered adipose tissue function on whole-body metabolism, diet-induced obesity in mice is frequently used as a model organism. In the current study, we have examined health-promoting effects of a lingonberry supplemented diet. We found C57BL/6J mice fed a high-fat diet supplemented with lingonberry for 4 days to have significantly lowered body-weight gain, adipose tissue expansion, and reduced insulin levels, compared to mice fed an isocaloric high-fat diet. RNA-Seq analysis of epididymal adipose tissue revealed differential expression of genes related to mitochondria fission (Mief1, Dnm1, Vps35, and Opa1). Further, we detected increased gene expression and phosphorylation of perilipin-1 (pS522), and increased lipolysis in primary adipocytes from lingonberry-fed mice. Together, these data pinpoint that beneficial effects of a lingonberry enriched diet are rapidly detectable and that the adipose tissue constitutes a target for these effects.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adipose tissue, High-fat diet, Lingonberry, Lipolysis
in
Journal of Functional Foods
volume
94
article number
105125
pages
1 - 8
publisher
Elsevier
external identifiers
  • scopus:85131059385
ISSN
1756-4646
DOI
10.1016/j.jff.2022.105125
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2022
id
d7e47aa0-7993-4ab2-9232-8752d6514e64
date added to LUP
2022-12-06 02:10:25
date last changed
2023-11-21 13:31:42
@article{d7e47aa0-7993-4ab2-9232-8752d6514e64,
  abstract     = {{<p>Intact adipose tissue function is essential to maintain glucose and lipid homeostasis. To study the impact of altered adipose tissue function on whole-body metabolism, diet-induced obesity in mice is frequently used as a model organism. In the current study, we have examined health-promoting effects of a lingonberry supplemented diet. We found C57BL/6J mice fed a high-fat diet supplemented with lingonberry for 4 days to have significantly lowered body-weight gain, adipose tissue expansion, and reduced insulin levels, compared to mice fed an isocaloric high-fat diet. RNA-Seq analysis of epididymal adipose tissue revealed differential expression of genes related to mitochondria fission (Mief1, Dnm1, Vps35, and Opa1). Further, we detected increased gene expression and phosphorylation of perilipin-1 (pS522), and increased lipolysis in primary adipocytes from lingonberry-fed mice. Together, these data pinpoint that beneficial effects of a lingonberry enriched diet are rapidly detectable and that the adipose tissue constitutes a target for these effects.</p>}},
  author       = {{Kotowska, Dorota and Neuhaus, Mathis and Heyman-Lindén, Lovisa and Morén, Björn and Li, Shuyi and Kryvokhyzha, Dmytro and Berger, Karin and Stenkula, Karin G.}},
  issn         = {{1756-4646}},
  keywords     = {{Adipose tissue; High-fat diet; Lingonberry; Lipolysis}},
  language     = {{eng}},
  pages        = {{1--8}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Functional Foods}},
  title        = {{Short-term lingonberry feeding is associated with decreased insulin levels and altered adipose tissue function in high-fat diet fed C57BL/6J mice}},
  url          = {{http://dx.doi.org/10.1016/j.jff.2022.105125}},
  doi          = {{10.1016/j.jff.2022.105125}},
  volume       = {{94}},
  year         = {{2022}},
}