Physiological development of a mixed metabolic and respiratory umbilical cord blood acidemia with advancing gestational age.
Wiberg, Nana LU
; Källén, Karin
LU
and Olofsson, Per
LU
(2006)
In Early Human Development
82(9).
p.583-589
- Abstract
- Objective: To investigate respiratory and metabolic components of gestational age-dependent umbilical cord blood gas changes. Study design: Cord blood gases were determined in 1336 vigorous singletons with uncomplicated cephatic vaginal delivery at 37-43 weeks. Linear regression analysis and non-parametric statistics were used with a P < 0.05 being significant. Results: Gestational age correlated negatively with arterial pH and HCO3- and positively with pCO(2) and base deficit. Venous blood showed corresponding changes except for pCO(2), which was independent of gestational age. Arterial pCO(2), but not venous, correlated positively with birthweight deviation from the mean. The fractional fetal CO2 production per birthweight unit and... (More)
- Objective: To investigate respiratory and metabolic components of gestational age-dependent umbilical cord blood gas changes. Study design: Cord blood gases were determined in 1336 vigorous singletons with uncomplicated cephatic vaginal delivery at 37-43 weeks. Linear regression analysis and non-parametric statistics were used with a P < 0.05 being significant. Results: Gestational age correlated negatively with arterial pH and HCO3- and positively with pCO(2) and base deficit. Venous blood showed corresponding changes except for pCO(2), which was independent of gestational age. Arterial pCO(2), but not venous, correlated positively with birthweight deviation from the mean. The fractional fetal CO2 production per birthweight unit and the fractional placental CO2 clearance per placental weight unit were not correlated with gestational age. Conclusions: A mixed respiratory and metabolic cord blood acidemia develops with advancing gestational age. The respiratory component depends on an increased 'CO2 load' fetus and not on deterioration of placental gas exchange. The etiology of the metabolic component is yet unknown. (c) 2006 Published by Elsevier Ireland Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/153535
- author
- Wiberg, Nana
LU
; Källén, Karin
LU
and Olofsson, Per
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- blood gases, umbilical cord, acidosis, gestational age, fetal, pregnancy
- in
- Early Human Development
- volume
- 82
- issue
- 9
- pages
- 583 - 589
- publisher
- Elsevier
- external identifiers
-
- pmid:16472947
- wos:000241092200002
- scopus:33747883774
- ISSN
- 1872-6232
- DOI
- 10.1016/j.earlhumdev.2005.12.005
- language
- English
- LU publication?
- yes
- id
- d86796ae-bb5c-4a58-b8f1-5544ddd54a5d (old id 153535)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16472947&dopt=Abstract
- date added to LUP
- 2016-04-01 16:54:40
- date last changed
- 2022-03-22 22:02:28
@article{d86796ae-bb5c-4a58-b8f1-5544ddd54a5d,
abstract = {{Objective: To investigate respiratory and metabolic components of gestational age-dependent umbilical cord blood gas changes. Study design: Cord blood gases were determined in 1336 vigorous singletons with uncomplicated cephatic vaginal delivery at 37-43 weeks. Linear regression analysis and non-parametric statistics were used with a P < 0.05 being significant. Results: Gestational age correlated negatively with arterial pH and HCO3- and positively with pCO(2) and base deficit. Venous blood showed corresponding changes except for pCO(2), which was independent of gestational age. Arterial pCO(2), but not venous, correlated positively with birthweight deviation from the mean. The fractional fetal CO2 production per birthweight unit and the fractional placental CO2 clearance per placental weight unit were not correlated with gestational age. Conclusions: A mixed respiratory and metabolic cord blood acidemia develops with advancing gestational age. The respiratory component depends on an increased 'CO2 load' fetus and not on deterioration of placental gas exchange. The etiology of the metabolic component is yet unknown. (c) 2006 Published by Elsevier Ireland Ltd.}},
author = {{Wiberg, Nana and Källén, Karin and Olofsson, Per}},
issn = {{1872-6232}},
keywords = {{blood gases; umbilical cord; acidosis; gestational age; fetal; pregnancy}},
language = {{eng}},
number = {{9}},
pages = {{583--589}},
publisher = {{Elsevier}},
series = {{Early Human Development}},
title = {{Physiological development of a mixed metabolic and respiratory umbilical cord blood acidemia with advancing gestational age.}},
url = {{https://lup.lub.lu.se/search/files/4816759/625336.pdf}},
doi = {{10.1016/j.earlhumdev.2005.12.005}},
volume = {{82}},
year = {{2006}},
}