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Alcohol Consumption and Risk of Parkinson's Disease : Data from a Large Prospective European Cohort

Peters, Susan ; Gallo, Valentina ; Vineis, Paolo ; Middleton, Lefkos T. ; Forsgren, Lars ; Sacerdote, Carlotta ; Sieri, Sabina ; Kyrozis, Andreas ; Chirlaque, María Dolores and Zamora-Ros, Raul , et al. (2020) In Movement Disorders 35(7). p.1258-1263
Abstract

Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were... (More)

Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5–29.9 g/day) were at ~50% higher risk compared with light consumption (0.1–4.9 g/day), but no linear exposure–response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alcohol, EPIC, epidemiology, Parkinson, prospective cohort
in
Movement Disorders
volume
35
issue
7
pages
6 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85084214967
  • pmid:32357270
ISSN
0885-3185
DOI
10.1002/mds.28039
language
English
LU publication?
yes
id
d8dc6ead-5b48-4d8d-a7b6-7a48187f7e08
date added to LUP
2020-05-27 12:40:09
date last changed
2024-04-03 05:16:10
@article{d8dc6ead-5b48-4d8d-a7b6-7a48187f7e08,
  abstract     = {{<p>Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5–29.9 g/day) were at ~50% higher risk compared with light consumption (0.1–4.9 g/day), but no linear exposure–response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk.</p>}},
  author       = {{Peters, Susan and Gallo, Valentina and Vineis, Paolo and Middleton, Lefkos T. and Forsgren, Lars and Sacerdote, Carlotta and Sieri, Sabina and Kyrozis, Andreas and Chirlaque, María Dolores and Zamora-Ros, Raul and Hansson, Oskar and Petersson, Jesper and Katzke, Verena and Kühn, Tilman and Mokoroa, Olatz and Masala, Giovanna and Ardanaz, Eva and Panico, Salvatore and Bergmann, Manuela M. and Key, Timothy J. and Weiderpass, Elisabete and Ferrari, Pietro and Vermeulen, Roel}},
  issn         = {{0885-3185}},
  keywords     = {{alcohol; EPIC; epidemiology; Parkinson; prospective cohort}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1258--1263}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Movement Disorders}},
  title        = {{Alcohol Consumption and Risk of Parkinson's Disease : Data from a Large Prospective European Cohort}},
  url          = {{http://dx.doi.org/10.1002/mds.28039}},
  doi          = {{10.1002/mds.28039}},
  volume       = {{35}},
  year         = {{2020}},
}