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Neutralizing Ljungan virus antibodies in children with newly diagnosed type 1 diabetes

Lundstig, Annika LU ; McDonald, Sharia L ; Maziarz, Marlena LU orcid ; Weldon, William C ; Vaziri-Sani, Fariba LU ; Lernmark, Åke LU orcid and Nilsson, Anna-Lena LU (2021) In The Journal of general virology 102(5).
Abstract

Ljungan virus (LV), a Parechovirus of the Picornavirus family, first isolated from a bank vole at the Ljungan river in Sweden, has been implicated in the risk for autoimmune type 1 diabetes. An assay for neutralizing Ljungan virus antibodies (NLVA) was developed using the original 87-012 LV isolate. The goal was to determine NLVA titres in incident 0-18 years old newly diagnosed type 1 diabetes patients (n=67) and school children controls (n=292) from Jämtland county in Sweden. NLVA were found in 41 of 67 (61 %) patients compared to 127 of 292 (44 %) controls (P=0.009). In the type 1 diabetes patients, NLVA titres were associated with autoantibodies to glutamic acid decarboxylase (GADA) (P=0.023), but not to autoantibodies against... (More)

Ljungan virus (LV), a Parechovirus of the Picornavirus family, first isolated from a bank vole at the Ljungan river in Sweden, has been implicated in the risk for autoimmune type 1 diabetes. An assay for neutralizing Ljungan virus antibodies (NLVA) was developed using the original 87-012 LV isolate. The goal was to determine NLVA titres in incident 0-18 years old newly diagnosed type 1 diabetes patients (n=67) and school children controls (n=292) from Jämtland county in Sweden. NLVA were found in 41 of 67 (61 %) patients compared to 127 of 292 (44 %) controls (P=0.009). In the type 1 diabetes patients, NLVA titres were associated with autoantibodies to glutamic acid decarboxylase (GADA) (P=0.023), but not to autoantibodies against insulin (IAA) or islet antigen-2 (IA-2A). The NLVA assay should prove useful for further investigations to determine levels of LV antibodies in patients and future studies to determine a possible role of LV in autoimmune type 1 diabetes.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of general virology
volume
102
issue
5
article number
1602
publisher
Microbiology Society
external identifiers
  • pmid:34020728
  • scopus:85106717963
ISSN
1465-2099
DOI
10.1099/jgv.0.001602
language
English
LU publication?
yes
id
d8df0d72-ca3b-4497-96e4-5cf765ab68f6
date added to LUP
2021-05-26 07:59:34
date last changed
2025-10-14 09:43:29
@article{d8df0d72-ca3b-4497-96e4-5cf765ab68f6,
  abstract     = {{<p>Ljungan virus (LV), a Parechovirus of the Picornavirus family, first isolated from a bank vole at the Ljungan river in Sweden, has been implicated in the risk for autoimmune type 1 diabetes. An assay for neutralizing Ljungan virus antibodies (NLVA) was developed using the original 87-012 LV isolate. The goal was to determine NLVA titres in incident 0-18 years old newly diagnosed type 1 diabetes patients (n=67) and school children controls (n=292) from Jämtland county in Sweden. NLVA were found in 41 of 67 (61 %) patients compared to 127 of 292 (44 %) controls (P=0.009). In the type 1 diabetes patients, NLVA titres were associated with autoantibodies to glutamic acid decarboxylase (GADA) (P=0.023), but not to autoantibodies against insulin (IAA) or islet antigen-2 (IA-2A). The NLVA assay should prove useful for further investigations to determine levels of LV antibodies in patients and future studies to determine a possible role of LV in autoimmune type 1 diabetes.</p>}},
  author       = {{Lundstig, Annika and McDonald, Sharia L and Maziarz, Marlena and Weldon, William C and Vaziri-Sani, Fariba and Lernmark, Åke and Nilsson, Anna-Lena}},
  issn         = {{1465-2099}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{Microbiology Society}},
  series       = {{The Journal of general virology}},
  title        = {{Neutralizing Ljungan virus antibodies in children with newly diagnosed type 1 diabetes}},
  url          = {{http://dx.doi.org/10.1099/jgv.0.001602}},
  doi          = {{10.1099/jgv.0.001602}},
  volume       = {{102}},
  year         = {{2021}},
}