Neutralizing Ljungan virus antibodies in children with newly diagnosed type 1 diabetes
(2021) In The Journal of general virology 102(5).- Abstract
Ljungan virus (LV), a Parechovirus of the Picornavirus family, first isolated from a bank vole at the Ljungan river in Sweden, has been implicated in the risk for autoimmune type 1 diabetes. An assay for neutralizing Ljungan virus antibodies (NLVA) was developed using the original 87-012 LV isolate. The goal was to determine NLVA titres in incident 0-18 years old newly diagnosed type 1 diabetes patients (n=67) and school children controls (n=292) from Jämtland county in Sweden. NLVA were found in 41 of 67 (61 %) patients compared to 127 of 292 (44 %) controls (P=0.009). In the type 1 diabetes patients, NLVA titres were associated with autoantibodies to glutamic acid decarboxylase (GADA) (P=0.023), but not to autoantibodies against... (More)
Ljungan virus (LV), a Parechovirus of the Picornavirus family, first isolated from a bank vole at the Ljungan river in Sweden, has been implicated in the risk for autoimmune type 1 diabetes. An assay for neutralizing Ljungan virus antibodies (NLVA) was developed using the original 87-012 LV isolate. The goal was to determine NLVA titres in incident 0-18 years old newly diagnosed type 1 diabetes patients (n=67) and school children controls (n=292) from Jämtland county in Sweden. NLVA were found in 41 of 67 (61 %) patients compared to 127 of 292 (44 %) controls (P=0.009). In the type 1 diabetes patients, NLVA titres were associated with autoantibodies to glutamic acid decarboxylase (GADA) (P=0.023), but not to autoantibodies against insulin (IAA) or islet antigen-2 (IA-2A). The NLVA assay should prove useful for further investigations to determine levels of LV antibodies in patients and future studies to determine a possible role of LV in autoimmune type 1 diabetes.
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- author
- Lundstig, Annika LU ; McDonald, Sharia L ; Maziarz, Marlena LU ; Weldon, William C ; Vaziri-Sani, Fariba LU ; Lernmark, Åke LU and Nilsson, Anna-Lena LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of general virology
- volume
- 102
- issue
- 5
- article number
- 1602
- publisher
- Microbiology Society
- external identifiers
-
- pmid:34020728
- scopus:85106717963
- ISSN
- 1465-2099
- DOI
- 10.1099/jgv.0.001602
- language
- English
- LU publication?
- yes
- id
- d8df0d72-ca3b-4497-96e4-5cf765ab68f6
- date added to LUP
- 2021-05-26 07:59:34
- date last changed
- 2024-03-23 04:53:38
@article{d8df0d72-ca3b-4497-96e4-5cf765ab68f6, abstract = {{<p>Ljungan virus (LV), a Parechovirus of the Picornavirus family, first isolated from a bank vole at the Ljungan river in Sweden, has been implicated in the risk for autoimmune type 1 diabetes. An assay for neutralizing Ljungan virus antibodies (NLVA) was developed using the original 87-012 LV isolate. The goal was to determine NLVA titres in incident 0-18 years old newly diagnosed type 1 diabetes patients (n=67) and school children controls (n=292) from Jämtland county in Sweden. NLVA were found in 41 of 67 (61 %) patients compared to 127 of 292 (44 %) controls (P=0.009). In the type 1 diabetes patients, NLVA titres were associated with autoantibodies to glutamic acid decarboxylase (GADA) (P=0.023), but not to autoantibodies against insulin (IAA) or islet antigen-2 (IA-2A). The NLVA assay should prove useful for further investigations to determine levels of LV antibodies in patients and future studies to determine a possible role of LV in autoimmune type 1 diabetes.</p>}}, author = {{Lundstig, Annika and McDonald, Sharia L and Maziarz, Marlena and Weldon, William C and Vaziri-Sani, Fariba and Lernmark, Åke and Nilsson, Anna-Lena}}, issn = {{1465-2099}}, language = {{eng}}, number = {{5}}, publisher = {{Microbiology Society}}, series = {{The Journal of general virology}}, title = {{Neutralizing Ljungan virus antibodies in children with newly diagnosed type 1 diabetes}}, url = {{http://dx.doi.org/10.1099/jgv.0.001602}}, doi = {{10.1099/jgv.0.001602}}, volume = {{102}}, year = {{2021}}, }