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A set-up for field studies of respiratory tract deposition of fine and ultrafine particles in humans

Löndahl, Jakob LU ; Pagels, Joakim LU ; Swietlicki, Erik LU ; Zhou, Jingchuan LU ; Ketzel, Matthias; Massling, Andreas and Bohgard, Mats LU (2006) In Journal of Aerosol Science 37(9). p.1152-1163
Abstract
Respiratory tract deposition data of ultrafine aerosol particles, hygroscopic particles and ambient particles in general are scarce. Measurements are associated with several difficulties. The objective of this work was to design a method for fast determination of highly size-resolved fine and ultrafine particle deposition, to be used on larger groups of human subjects in exposure studies and in typical ambient and indoor environments. The particle size distributions in dried samples of the inhaled and exhaled air are characterised with an electrical mobility spectrometer. A particle counter desmearing procedure reduces the spectrometer scan time. The precision and sensitivity of the method was tested for hygroscopic sodium chloride (NaCl)... (More)
Respiratory tract deposition data of ultrafine aerosol particles, hygroscopic particles and ambient particles in general are scarce. Measurements are associated with several difficulties. The objective of this work was to design a method for fast determination of highly size-resolved fine and ultrafine particle deposition, to be used on larger groups of human subjects in exposure studies and in typical ambient and indoor environments. The particle size distributions in dried samples of the inhaled and exhaled air are characterised with an electrical mobility spectrometer. A particle counter desmearing procedure reduces the spectrometer scan time. The precision and sensitivity of the method was tested for hygroscopic sodium chloride (NaCl) and hydrophobic Di-Ethyl-Hexyl-Sebacate (DEHS) aerosols in repeated identical experiments and experiments with different breathing frequencies on a single subject. The accuracy of the method was estimated by comparing results from three subjects with previous data obtained with monodisperse particles and with the well-established International Commission on Radiological Protection model (1994). Potential errors due to size shifts between the inhaled and exhaled samples and coagulation were simulated. The system has low losses in the studied particle size range (10-475 nm), typically 10% or less of the fraction deposited in the respiratory tract. Coagulation is noticeable at 10(5) cm(-3) but can be corrected for up to 5 x 10(5) cm(-3). The precision in the determined deposited fraction is 0.02-0.08. The method is sensitive enough to quantify differences between breathing patterns and differences between hygroscopic and hydrophobic aerosols. Our results for NaCl and DEHS are in agreement with the ICRP 66 model [International Commission on Radiological Protection. (1994). Human respiratory tract model for radiological protection (ICRP Publication 66). Oxford, UK: Elsevier Science], and also suggest that the relative humidity in the respiratory tract is close to 99.5%. A respiratory tract deposition measurement can be done in 15-30 min. Recommendations are given for field applications of the method. (C) 2005 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lung, number, respiratory deposition, exposure, fine particles, aerosols, ultrafine particles
in
Journal of Aerosol Science
volume
37
issue
9
pages
1152 - 1163
publisher
Elsevier
external identifiers
  • wos:000241223900008
  • scopus:33747811126
ISSN
0021-8502
DOI
10.1016/j.jaerosci.2005.11.004
language
English
LU publication?
yes
id
d8e2d824-9fdb-417b-ac88-a70adde2909a (old id 388416)
date added to LUP
2007-10-09 09:38:20
date last changed
2019-07-16 02:35:00
@article{d8e2d824-9fdb-417b-ac88-a70adde2909a,
  abstract     = {Respiratory tract deposition data of ultrafine aerosol particles, hygroscopic particles and ambient particles in general are scarce. Measurements are associated with several difficulties. The objective of this work was to design a method for fast determination of highly size-resolved fine and ultrafine particle deposition, to be used on larger groups of human subjects in exposure studies and in typical ambient and indoor environments. The particle size distributions in dried samples of the inhaled and exhaled air are characterised with an electrical mobility spectrometer. A particle counter desmearing procedure reduces the spectrometer scan time. The precision and sensitivity of the method was tested for hygroscopic sodium chloride (NaCl) and hydrophobic Di-Ethyl-Hexyl-Sebacate (DEHS) aerosols in repeated identical experiments and experiments with different breathing frequencies on a single subject. The accuracy of the method was estimated by comparing results from three subjects with previous data obtained with monodisperse particles and with the well-established International Commission on Radiological Protection model (1994). Potential errors due to size shifts between the inhaled and exhaled samples and coagulation were simulated. The system has low losses in the studied particle size range (10-475 nm), typically 10% or less of the fraction deposited in the respiratory tract. Coagulation is noticeable at 10(5) cm(-3) but can be corrected for up to 5 x 10(5) cm(-3). The precision in the determined deposited fraction is 0.02-0.08. The method is sensitive enough to quantify differences between breathing patterns and differences between hygroscopic and hydrophobic aerosols. Our results for NaCl and DEHS are in agreement with the ICRP 66 model [International Commission on Radiological Protection. (1994). Human respiratory tract model for radiological protection (ICRP Publication 66). Oxford, UK: Elsevier Science], and also suggest that the relative humidity in the respiratory tract is close to 99.5%. A respiratory tract deposition measurement can be done in 15-30 min. Recommendations are given for field applications of the method. (C) 2005 Elsevier Ltd. All rights reserved.},
  author       = {Löndahl, Jakob and Pagels, Joakim and Swietlicki, Erik and Zhou, Jingchuan and Ketzel, Matthias and Massling, Andreas and Bohgard, Mats},
  issn         = {0021-8502},
  keyword      = {lung,number,respiratory deposition,exposure,fine particles,aerosols,ultrafine particles},
  language     = {eng},
  number       = {9},
  pages        = {1152--1163},
  publisher    = {Elsevier},
  series       = {Journal of Aerosol Science},
  title        = {A set-up for field studies of respiratory tract deposition of fine and ultrafine particles in humans},
  url          = {http://dx.doi.org/10.1016/j.jaerosci.2005.11.004},
  volume       = {37},
  year         = {2006},
}