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Interactions in Aqueous Mixtures of Cationic Hydroxyethyl Cellulose and Different Anionic Bile Salts

Tan, Julia Jianwei ; Gjerde, Natalie ; Del Giudice, Alessandra ; Knudsen, Kenneth D. ; Galantini, Luciano ; Du, Guanqun LU ; Schillén, Karin LU orcid ; Sande, Sverre Arne and Nyström, Bo (2023) In Journal of Agricultural and Food Chemistry 71(8). p.3732-3741
Abstract

It is known that the reduction of blood cholesterol can be accomplished through foods containing a large number of dietary fibers; this process is partially related to the binding of bile salt to fibers. To gain new insights into the interactions between dietary fibers and bile salts, this study investigates the interactions between cationic hydroxyethyl cellulose (catHEC) and sodium deoxycholate (NaDC) or sodium cholate (NaC), which have a similar structure. Turbidity measurements reveal strong interactions between catHEC and NaDC, and under some conditions, macroscopic phase separation occurs. In contrast, the interactions with NaC are weak. At a catHEC concentration of 2 wt %, incipient phase separation is approached at... (More)

It is known that the reduction of blood cholesterol can be accomplished through foods containing a large number of dietary fibers; this process is partially related to the binding of bile salt to fibers. To gain new insights into the interactions between dietary fibers and bile salts, this study investigates the interactions between cationic hydroxyethyl cellulose (catHEC) and sodium deoxycholate (NaDC) or sodium cholate (NaC), which have a similar structure. Turbidity measurements reveal strong interactions between catHEC and NaDC, and under some conditions, macroscopic phase separation occurs. In contrast, the interactions with NaC are weak. At a catHEC concentration of 2 wt %, incipient phase separation is approached at concentrations of NaC and NaDC of 32.5 and 19.3 mM, respectively. The rheological results show strong interactions and a prominent viscosification effect for the catHEC/NaDC system but only moderate interactions for the catHEC/NaC system. Both cryogenic transmission electron microscopy and small-angle X-ray scattering results display fundamental structural differences between the two systems, which may explain the stronger interactions in the presence of NaDC. The surmise is that the extended structures formed in the presence of NaDC can easily form connections and entanglements in the network.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bile salts, cationic hydroxyethyl cellulose, cryo-TEM, interactions, rheology, SAXS
in
Journal of Agricultural and Food Chemistry
volume
71
issue
8
pages
10 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:85148370496
  • pmid:36791398
ISSN
0021-8561
DOI
10.1021/acs.jafc.3c00076
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2023 The Authors. Published by American Chemical Society.
id
da1bde10-09d0-4bf4-b22f-745bd6bdd558
date added to LUP
2023-03-08 00:52:38
date last changed
2024-06-13 10:03:34
@article{da1bde10-09d0-4bf4-b22f-745bd6bdd558,
  abstract     = {{<p>It is known that the reduction of blood cholesterol can be accomplished through foods containing a large number of dietary fibers; this process is partially related to the binding of bile salt to fibers. To gain new insights into the interactions between dietary fibers and bile salts, this study investigates the interactions between cationic hydroxyethyl cellulose (catHEC) and sodium deoxycholate (NaDC) or sodium cholate (NaC), which have a similar structure. Turbidity measurements reveal strong interactions between catHEC and NaDC, and under some conditions, macroscopic phase separation occurs. In contrast, the interactions with NaC are weak. At a catHEC concentration of 2 wt %, incipient phase separation is approached at concentrations of NaC and NaDC of 32.5 and 19.3 mM, respectively. The rheological results show strong interactions and a prominent viscosification effect for the catHEC/NaDC system but only moderate interactions for the catHEC/NaC system. Both cryogenic transmission electron microscopy and small-angle X-ray scattering results display fundamental structural differences between the two systems, which may explain the stronger interactions in the presence of NaDC. The surmise is that the extended structures formed in the presence of NaDC can easily form connections and entanglements in the network.</p>}},
  author       = {{Tan, Julia Jianwei and Gjerde, Natalie and Del Giudice, Alessandra and Knudsen, Kenneth D. and Galantini, Luciano and Du, Guanqun and Schillén, Karin and Sande, Sverre Arne and Nyström, Bo}},
  issn         = {{0021-8561}},
  keywords     = {{bile salts; cationic hydroxyethyl cellulose; cryo-TEM; interactions; rheology; SAXS}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{3732--3741}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Journal of Agricultural and Food Chemistry}},
  title        = {{Interactions in Aqueous Mixtures of Cationic Hydroxyethyl Cellulose and Different Anionic Bile Salts}},
  url          = {{http://dx.doi.org/10.1021/acs.jafc.3c00076}},
  doi          = {{10.1021/acs.jafc.3c00076}},
  volume       = {{71}},
  year         = {{2023}},
}