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Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients

Topi, Geriolda LU ; Ghatak, Souvik LU ; Satapathy, Shakti Ranjan LU ; Ehrnström, Roy LU ; Lydrup, Marie Louise LU and Sjölander, Anita LU (2022) In Frontiers in Medicine 9.
Abstract

We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female patients with CRC, which, to the best of our knowledge, is the first study to investigate this topic. A total number of 306 primary CRCs were immunostained for ERα and ERβ expression. A Cox regression model was used to evaluate overall survival (OS) and disease-free survival (DFS). The combined expression of high ERβ + negative ERα correlates... (More)

We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female patients with CRC, which, to the best of our knowledge, is the first study to investigate this topic. A total number of 306 primary CRCs were immunostained for ERα and ERβ expression. A Cox regression model was used to evaluate overall survival (OS) and disease-free survival (DFS). The combined expression of high ERβ + negative ERα correlates with longer OS (HR = 0.23; 95% CI: 0.11–0.45, P <0.0001) and DFS (HR = 0.10; 95% CI: 0.03–0.26, P < 0.0001) and a more favorable tumor outcome, as well as significantly higher expression of antitumorigenic proteins than combined expression of low ERβ + positive ERα. Importantly, we found that low ERβ expression was associated with local recurrence of CRC, whereas ERα expression was correlated with liver metastasis. Overall, our results show that the combined high ERβ + negative ERα expression correlated with a better prognosis for CRC patients. Our results suggest that the combined expression of ERα and ERβ could be used as a predictive combination marker for CRC patients, especially for predicting DFS.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
colorectal cancer, CRC disease-free survival, CRC overall survival, estrogen receptor alpha, estrogen receptor beta
in
Frontiers in Medicine
volume
9
article number
739620
publisher
Frontiers Media S. A.
external identifiers
  • pmid:35360718
  • scopus:85127635447
ISSN
2296-858X
DOI
10.3389/fmed.2022.739620
language
English
LU publication?
yes
id
da72f8f0-077c-49f2-b594-210a9bff0d14
date added to LUP
2022-06-10 10:26:21
date last changed
2024-06-13 17:19:54
@article{da72f8f0-077c-49f2-b594-210a9bff0d14,
  abstract     = {{<p>We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female patients with CRC, which, to the best of our knowledge, is the first study to investigate this topic. A total number of 306 primary CRCs were immunostained for ERα and ERβ expression. A Cox regression model was used to evaluate overall survival (OS) and disease-free survival (DFS). The combined expression of high ERβ + negative ERα correlates with longer OS (HR = 0.23; 95% CI: 0.11–0.45, P &lt;0.0001) and DFS (HR = 0.10; 95% CI: 0.03–0.26, P &lt; 0.0001) and a more favorable tumor outcome, as well as significantly higher expression of antitumorigenic proteins than combined expression of low ERβ + positive ERα. Importantly, we found that low ERβ expression was associated with local recurrence of CRC, whereas ERα expression was correlated with liver metastasis. Overall, our results show that the combined high ERβ + negative ERα expression correlated with a better prognosis for CRC patients. Our results suggest that the combined expression of ERα and ERβ could be used as a predictive combination marker for CRC patients, especially for predicting DFS.</p>}},
  author       = {{Topi, Geriolda and Ghatak, Souvik and Satapathy, Shakti Ranjan and Ehrnström, Roy and Lydrup, Marie Louise and Sjölander, Anita}},
  issn         = {{2296-858X}},
  keywords     = {{colorectal cancer; CRC disease-free survival; CRC overall survival; estrogen receptor alpha; estrogen receptor beta}},
  language     = {{eng}},
  month        = {{03}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Medicine}},
  title        = {{Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients}},
  url          = {{http://dx.doi.org/10.3389/fmed.2022.739620}},
  doi          = {{10.3389/fmed.2022.739620}},
  volume       = {{9}},
  year         = {{2022}},
}