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A longitudinal analysis of the relationships of physical activity and body fat with nerve growth factor and brain-derived neural factor in children

Arvidsson, Daniel LU ; Johannesson, Elias ; Andersen, Lars Bo ; Karlsson, Magnus LU ; Wollmer, Per LU ; Thorsson, Ola LU and Dencker, Magnus LU (2018) In Journal of Physical Activity and Health 15(8). p.620-625
Abstract

Background: Nerve growth factor (NGF) and brain-derived neural factor (BDNF) are important for brain function and detectable in the blood. This study explored the longitudinal associations of physical activity and body fat with serum NGF and BDNF in children. Methods: Two waves of measurements were performed 2 years apart in 8- to 11-year-old children, including physical activity using the ActiGraph model 7164, body composition by dual-energy X-ray absorptiometry, and serum NGF and BDNF determined by multiplex immunoassay. The first wave included 248 children. Full information maximum likelihood estimation with robust standard errors was applied in structural equation modeling. Results: Vigorous physical activity showed a direct... (More)

Background: Nerve growth factor (NGF) and brain-derived neural factor (BDNF) are important for brain function and detectable in the blood. This study explored the longitudinal associations of physical activity and body fat with serum NGF and BDNF in children. Methods: Two waves of measurements were performed 2 years apart in 8- to 11-year-old children, including physical activity using the ActiGraph model 7164, body composition by dual-energy X-ray absorptiometry, and serum NGF and BDNF determined by multiplex immunoassay. The first wave included 248 children. Full information maximum likelihood estimation with robust standard errors was applied in structural equation modeling. Results: Vigorous physical activity showed a direct positive longitudinal relationship with NGF (standardized coefficient β = 0.30, P = .01) but not with BDNF (β = 0.04, P = .84). At the same time, body fat percentage was positively related to both NGF (β = 0.59, P < .001) and BDNF (β = 0.17, P = .04). There was an indication of an indirect relationship of vigorous physical activity with NGF (product of unstandardized coefficient β = −0.18, P = .02) and BDNF (β = −0.07, P = .05) through the negative relationship with body fat percentage (β = −0.36, P < .001). Conclusions: Vigorous physical activity is directly related to serum NGF and indirectly through the level of body fat. The relationships with serum BDNF are more complex.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Accelerometer, Dual-energy X-ray absorptiometry, Neurotrophins, Serum, Structural equation modeling
in
Journal of Physical Activity and Health
volume
15
issue
8
pages
6 pages
publisher
Human Kinetics
external identifiers
  • scopus:85052017542
  • pmid:29589508
ISSN
1543-3080
DOI
10.1123/jpah.2017-0483
language
English
LU publication?
yes
id
da998fa2-5dd0-41ca-ba60-bb1f4edc1cbc
date added to LUP
2018-10-17 14:43:27
date last changed
2025-04-04 14:29:49
@article{da998fa2-5dd0-41ca-ba60-bb1f4edc1cbc,
  abstract     = {{<p>Background: Nerve growth factor (NGF) and brain-derived neural factor (BDNF) are important for brain function and detectable in the blood. This study explored the longitudinal associations of physical activity and body fat with serum NGF and BDNF in children. Methods: Two waves of measurements were performed 2 years apart in 8- to 11-year-old children, including physical activity using the ActiGraph model 7164, body composition by dual-energy X-ray absorptiometry, and serum NGF and BDNF determined by multiplex immunoassay. The first wave included 248 children. Full information maximum likelihood estimation with robust standard errors was applied in structural equation modeling. Results: Vigorous physical activity showed a direct positive longitudinal relationship with NGF (standardized coefficient β = 0.30, P = .01) but not with BDNF (β = 0.04, P = .84). At the same time, body fat percentage was positively related to both NGF (β = 0.59, P &lt; .001) and BDNF (β = 0.17, P = .04). There was an indication of an indirect relationship of vigorous physical activity with NGF (product of unstandardized coefficient β = −0.18, P = .02) and BDNF (β = −0.07, P = .05) through the negative relationship with body fat percentage (β = −0.36, P &lt; .001). Conclusions: Vigorous physical activity is directly related to serum NGF and indirectly through the level of body fat. The relationships with serum BDNF are more complex.</p>}},
  author       = {{Arvidsson, Daniel and Johannesson, Elias and Andersen, Lars Bo and Karlsson, Magnus and Wollmer, Per and Thorsson, Ola and Dencker, Magnus}},
  issn         = {{1543-3080}},
  keywords     = {{Accelerometer; Dual-energy X-ray absorptiometry; Neurotrophins; Serum; Structural equation modeling}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{8}},
  pages        = {{620--625}},
  publisher    = {{Human Kinetics}},
  series       = {{Journal of Physical Activity and Health}},
  title        = {{A longitudinal analysis of the relationships of physical activity and body fat with nerve growth factor and brain-derived neural factor in children}},
  url          = {{http://dx.doi.org/10.1123/jpah.2017-0483}},
  doi          = {{10.1123/jpah.2017-0483}},
  volume       = {{15}},
  year         = {{2018}},
}