Bisphenol A in human saliva and urine before and after treatment with dental polymer-based restorative materials
Berge, Trine L.L. ; Lygre, Gunvor B. ; Lie, Stein A. ; Lindh, Christian H. LU
and Björkman, Lars
(2019)
In European Journal of Oral Sciences
127(5).
p.435-444
- Abstract
The aim of this study was to quantify bisphenol A (BPA) concentrations in saliva and urine before and after treatment with dental polymer-based restorative materials to assess if placement of this material is associated with increased BPA levels in saliva and urine. Twenty individuals in need of at least one dental restoration with polymer-based restorative material were included in this study. The participants were instructed to abstain from eating, drinking, and brushing their teeth for at least 10 h prior to sampling. Saliva and urine were collected before and 10 min (saliva only), 1 h, 24 h, and 1 wk after treatment. Samples were stored at −80°C before analyses. BPA in saliva and urine was determined with liquid chromatography/mass... (More)
The aim of this study was to quantify bisphenol A (BPA) concentrations in saliva and urine before and after treatment with dental polymer-based restorative materials to assess if placement of this material is associated with increased BPA levels in saliva and urine. Twenty individuals in need of at least one dental restoration with polymer-based restorative material were included in this study. The participants were instructed to abstain from eating, drinking, and brushing their teeth for at least 10 h prior to sampling. Saliva and urine were collected before and 10 min (saliva only), 1 h, 24 h, and 1 wk after treatment. Samples were stored at −80°C before analyses. BPA in saliva and urine was determined with liquid chromatography/mass spectrometry. Linear mixed effects regression models were used for statistical analyses. There was a statistically significant increase of salivary BPA concentration directly after placement of the dental polymer-based restorations. Following placement, the concentration of BPA decreased exponentially with time. One week after treatment the BPA level in saliva was only marginally higher than before treatment. In urine, no statistically significant change of the BPA concentration was detected after treatment.
(Less)
- author
- Berge, Trine L.L.
; Lygre, Gunvor B.
; Lie, Stein A.
; Lindh, Christian H.
LU
and Björkman, Lars
- organization
- publishing date
- 2019-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- composite filling, exposure to BPA, resin-based material, saliva, urine
- in
- European Journal of Oral Sciences
- volume
- 127
- issue
- 5
- pages
- 435 - 444
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:31392814
- scopus:85070690512
- ISSN
- 0909-8836
- DOI
- 10.1111/eos.12647
- language
- English
- LU publication?
- yes
- additional info
- Funding Information: The authors want to give special thanks to the participants of this study. We also appreciate the support from The Public Dental Services in Hordaland County and skillful help from personnel at the dental clinics (Årstad and Sammen/Student Welfare Organization in Bergen). We acknowledge Carina S Nilsson and Margareta Maxe, Lund University, Sweden, for technical assistance with the analyses of BPA. Hilde M Kopperud and Lene A Grutle, Nordic Institute of Dental Materials, Norway, are acknowledged for skillful help with the additional analyses of BPA. The Norwegian Dental Biomaterials Adverse Reaction Unit and the Oral Health Centre of Expertise in Western Norway are funded by the Norwegian Ministry of Health and Care Services. The study was supported by the Norwegian Directorate of Health. Publisher Copyright: © 2019 The Authors. Eur J Oral Sci published by John Wiley & Sons Ltd
- id
- dac79d35-eaac-48d2-8a69-73e724e66df9
- date added to LUP
- 2023-09-26 10:33:31
- date last changed
- 2024-04-19 01:40:17
@article{dac79d35-eaac-48d2-8a69-73e724e66df9,
abstract = {{<p>The aim of this study was to quantify bisphenol A (BPA) concentrations in saliva and urine before and after treatment with dental polymer-based restorative materials to assess if placement of this material is associated with increased BPA levels in saliva and urine. Twenty individuals in need of at least one dental restoration with polymer-based restorative material were included in this study. The participants were instructed to abstain from eating, drinking, and brushing their teeth for at least 10 h prior to sampling. Saliva and urine were collected before and 10 min (saliva only), 1 h, 24 h, and 1 wk after treatment. Samples were stored at −80°C before analyses. BPA in saliva and urine was determined with liquid chromatography/mass spectrometry. Linear mixed effects regression models were used for statistical analyses. There was a statistically significant increase of salivary BPA concentration directly after placement of the dental polymer-based restorations. Following placement, the concentration of BPA decreased exponentially with time. One week after treatment the BPA level in saliva was only marginally higher than before treatment. In urine, no statistically significant change of the BPA concentration was detected after treatment.</p>}},
author = {{Berge, Trine L.L. and Lygre, Gunvor B. and Lie, Stein A. and Lindh, Christian H. and Björkman, Lars}},
issn = {{0909-8836}},
keywords = {{composite filling; exposure to BPA; resin-based material; saliva; urine}},
language = {{eng}},
month = {{10}},
number = {{5}},
pages = {{435--444}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Oral Sciences}},
title = {{Bisphenol A in human saliva and urine before and after treatment with dental polymer-based restorative materials}},
url = {{http://dx.doi.org/10.1111/eos.12647}},
doi = {{10.1111/eos.12647}},
volume = {{127}},
year = {{2019}},
}