Duration of electrocardiographic TPEAK-TEND interval in ischemia : Dispersion of repolarization vs. myocardium area at risk
(2025) In Journal of Electrocardiology 93.- Abstract
Introduction: Tpeak-Tend interval (Tpe) is considered to be an ECG reflection of the dispersion of repolarization (DOR), and as such has been proposed as a predictor of arrhythmias. In ischemia, robustness of the Tpe-DOR relationship may suffer from variability of the myocardium at risk (MaR) area. In the present study, we evaluated the contribution of DOR and MaR to single‑lead and multi‑lead Tpe durations. Methods: Ischemia was induced by 40-min proximal or distal ligations of the left anterior descending coronary artery in 27 anesthetized pigs. In 48 intramyocardial leads, end of repolarization times (RTs) were determined as the instant of dV/dt max during T-wave, and DOR was calculated as the difference between RTmax and RTmin. In... (More)
Introduction: Tpeak-Tend interval (Tpe) is considered to be an ECG reflection of the dispersion of repolarization (DOR), and as such has been proposed as a predictor of arrhythmias. In ischemia, robustness of the Tpe-DOR relationship may suffer from variability of the myocardium at risk (MaR) area. In the present study, we evaluated the contribution of DOR and MaR to single‑lead and multi‑lead Tpe durations. Methods: Ischemia was induced by 40-min proximal or distal ligations of the left anterior descending coronary artery in 27 anesthetized pigs. In 48 intramyocardial leads, end of repolarization times (RTs) were determined as the instant of dV/dt max during T-wave, and DOR was calculated as the difference between RTmax and RTmin. In standard 12‑lead ECGs, we determined a single‑lead Tpe (maximal value throughout all leads) and a multi‑lead Tpe as the difference between the earliest Tpeak and latest Tend throughout all leads. MaR was assessed by postmortem Evans blue staining. Results: During 40-min ischemia, DOR and Tpe increased concurrently, but DOR was greater than Tpe at all time-points, especially during ischemia. In univariate linear regression analysis, maximal DOR during occlusion was significantly associated with maximal multi‑lead Tpe, but was not associated with single‑lead Tpe. MaR was significantly associated with maximal single‑lead Tpe, but not with multi‑lead Tpe or DOR. Conclusion: Both multi‑lead and single‑lead Tpe underestimated DOR, especially at ischemia. Variation of the size of the ischemic region appeared to be an important factor in evaluating the single‑lead Tpe interval.
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- author
- Poselyaninov, Alexander S. ; Tsvetkova, Alena S. ; Khomenko, Pyotr V. ; Grubbe, Maria E. ; Ovechkin, Alexey O. ; Bernikova, Olesya G. ; Demidova, Marina M. LU ; Azarov, Jan E. and Platonov, Pyotr G. LU
- organization
- publishing date
- 2025-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Dispersion of repolarization, Electrocardiogram, Multi‑lead, Myocardium area at risk, Single‑lead, Tpeak-Tend
- in
- Journal of Electrocardiology
- volume
- 93
- article number
- 154129
- publisher
- Elsevier
- external identifiers
-
- scopus:105016395022
- pmid:40976087
- ISSN
- 0022-0736
- DOI
- 10.1016/j.jelectrocard.2025.154129
- language
- English
- LU publication?
- yes
- id
- daf7a366-e145-450b-8722-20937fee6047
- date added to LUP
- 2025-10-03 13:46:28
- date last changed
- 2025-10-17 15:40:08
@article{daf7a366-e145-450b-8722-20937fee6047,
abstract = {{<p>Introduction: Tpeak-Tend interval (Tpe) is considered to be an ECG reflection of the dispersion of repolarization (DOR), and as such has been proposed as a predictor of arrhythmias. In ischemia, robustness of the Tpe-DOR relationship may suffer from variability of the myocardium at risk (MaR) area. In the present study, we evaluated the contribution of DOR and MaR to single‑lead and multi‑lead Tpe durations. Methods: Ischemia was induced by 40-min proximal or distal ligations of the left anterior descending coronary artery in 27 anesthetized pigs. In 48 intramyocardial leads, end of repolarization times (RTs) were determined as the instant of dV/dt max during T-wave, and DOR was calculated as the difference between RTmax and RTmin. In standard 12‑lead ECGs, we determined a single‑lead Tpe (maximal value throughout all leads) and a multi‑lead Tpe as the difference between the earliest Tpeak and latest Tend throughout all leads. MaR was assessed by postmortem Evans blue staining. Results: During 40-min ischemia, DOR and Tpe increased concurrently, but DOR was greater than Tpe at all time-points, especially during ischemia. In univariate linear regression analysis, maximal DOR during occlusion was significantly associated with maximal multi‑lead Tpe, but was not associated with single‑lead Tpe. MaR was significantly associated with maximal single‑lead Tpe, but not with multi‑lead Tpe or DOR. Conclusion: Both multi‑lead and single‑lead Tpe underestimated DOR, especially at ischemia. Variation of the size of the ischemic region appeared to be an important factor in evaluating the single‑lead Tpe interval.</p>}},
author = {{Poselyaninov, Alexander S. and Tsvetkova, Alena S. and Khomenko, Pyotr V. and Grubbe, Maria E. and Ovechkin, Alexey O. and Bernikova, Olesya G. and Demidova, Marina M. and Azarov, Jan E. and Platonov, Pyotr G.}},
issn = {{0022-0736}},
keywords = {{Dispersion of repolarization; Electrocardiogram; Multi‑lead; Myocardium area at risk; Single‑lead; Tpeak-Tend}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Journal of Electrocardiology}},
title = {{Duration of electrocardiographic T<sub>PEAK</sub>-T<sub>END</sub> interval in ischemia : Dispersion of repolarization vs. myocardium area at risk}},
url = {{http://dx.doi.org/10.1016/j.jelectrocard.2025.154129}},
doi = {{10.1016/j.jelectrocard.2025.154129}},
volume = {{93}},
year = {{2025}},
}