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The epidemiology of metastases in neuroendocrine tumors

Riihimäki, Matias LU ; Hemminki, Akseli; Sundquist, Kristina LU ; Sundquist, Jan LU and Hemminki, Kari LU (2016) In International Journal of Cancer 139(12). p.2679-2686
Abstract

The epidemiology of metastases in neuroendocrine tumors (NETs) is virtually unknown. The present novel approach took use of two nationwide Swedish registers to assess the distribution of metastatic sites in comparison to adenocarcinoma. 7,334 patients with NET were identified from the Swedish Cancer Registry. Metastatic sites were identified from the National Patient and Cause of Death Registries. Sites of metastasis were investigated depending on the primary site of NET. The metastatic potential of NET was assessed. The liver was the most common site of metastasis (82% of patients with metastases), and the small intestine was the most common source of NET metastases. Of all patients with metastatic lung NETs, 66% had liver metastases,... (More)

The epidemiology of metastases in neuroendocrine tumors (NETs) is virtually unknown. The present novel approach took use of two nationwide Swedish registers to assess the distribution of metastatic sites in comparison to adenocarcinoma. 7,334 patients with NET were identified from the Swedish Cancer Registry. Metastatic sites were identified from the National Patient and Cause of Death Registries. Sites of metastasis were investigated depending on the primary site of NET. The metastatic potential of NET was assessed. The liver was the most common site of metastasis (82% of patients with metastases), and the small intestine was the most common source of NET metastases. Of all patients with metastatic lung NETs, 66% had liver metastases, whereas the corresponding number for adenocarcinoma of lung was only 20%. The risk of metastasis was highest if the primary was in the small intestine or pancreatohepatobiliary tract, whereas it was lower with appendiceal and rectal NET. Men had more bone metastases compared to women. Patients with metastatic NET had worse prognosis if the primary site was unknown (11 months, 9% of NET patients) compared to those whose primary was known (19 months). The metastatic potential of NETs varies profoundly depending on the primary site. NETs show a clear preference to metastasize to the liver. Surveillance of liver metastases may enable earlier diagnosis and treatment. In liver metastases from NET, the small intestine should be suspected as the primary site, whereas the lung should be suspected in nervous system metastases of NET origin.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
cancer of unknown primary, carcinoid, epidemiology, metastasis, neuroendocrine tumor
in
International Journal of Cancer
volume
139
issue
12
pages
8 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:84994099215
  • wos:000387619400005
ISSN
0020-7136
DOI
10.1002/ijc.30400
language
English
LU publication?
yes
id
db40eefc-ef01-4c4f-93cb-9f27b6b0fa60
date added to LUP
2016-11-18 11:34:14
date last changed
2017-09-24 05:03:19
@article{db40eefc-ef01-4c4f-93cb-9f27b6b0fa60,
  abstract     = {<p>The epidemiology of metastases in neuroendocrine tumors (NETs) is virtually unknown. The present novel approach took use of two nationwide Swedish registers to assess the distribution of metastatic sites in comparison to adenocarcinoma. 7,334 patients with NET were identified from the Swedish Cancer Registry. Metastatic sites were identified from the National Patient and Cause of Death Registries. Sites of metastasis were investigated depending on the primary site of NET. The metastatic potential of NET was assessed. The liver was the most common site of metastasis (82% of patients with metastases), and the small intestine was the most common source of NET metastases. Of all patients with metastatic lung NETs, 66% had liver metastases, whereas the corresponding number for adenocarcinoma of lung was only 20%. The risk of metastasis was highest if the primary was in the small intestine or pancreatohepatobiliary tract, whereas it was lower with appendiceal and rectal NET. Men had more bone metastases compared to women. Patients with metastatic NET had worse prognosis if the primary site was unknown (11 months, 9% of NET patients) compared to those whose primary was known (19 months). The metastatic potential of NETs varies profoundly depending on the primary site. NETs show a clear preference to metastasize to the liver. Surveillance of liver metastases may enable earlier diagnosis and treatment. In liver metastases from NET, the small intestine should be suspected as the primary site, whereas the lung should be suspected in nervous system metastases of NET origin.</p>},
  author       = {Riihimäki, Matias and Hemminki, Akseli and Sundquist, Kristina and Sundquist, Jan and Hemminki, Kari},
  issn         = {0020-7136},
  keyword      = {cancer of unknown primary,carcinoid,epidemiology,metastasis,neuroendocrine tumor},
  language     = {eng},
  month        = {12},
  number       = {12},
  pages        = {2679--2686},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {The epidemiology of metastases in neuroendocrine tumors},
  url          = {http://dx.doi.org/10.1002/ijc.30400},
  volume       = {139},
  year         = {2016},
}