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Quantitative myocardial perfusion during stress using CMR is impaired in healthy Middle Eastern immigrants without CV risk factors

Jablonowski, Robert LU ; Bennet, Louise LU orcid ; Engblom, Henrik LU ; Aletras, Anthony H LU orcid ; Xue, Hui ; Kellman, Peter LU ; Carlsson, Marcus LU and Arheden, Håkan LU (2022) In Scientific Reports 12(1).
Abstract

Middle Eastern immigrants constitute a growing proportion of the European population and compared to native Swedes are more insulin resistant, which can contribute to atherosclerosis. Quantitative first pass perfusion (qFPP) using cardiovascular magnetic resonance (CMR) can detect early signs of cardiovascular disease (CVD). The aim was to study if myocardial perfusion differs between healthy male Middle Eastern immigrants and native male Swedes. Eighteen Iraqi- and twelve Swedish born controls, all males, never smokers with no CVD risk factors were included. Global myocardial perfusion at rest and stress was assessed using qFPP and by phase-contrast CMR imaging of coronary sinus flow. Quantitative first pass perfusion analysis (mean ±... (More)

Middle Eastern immigrants constitute a growing proportion of the European population and compared to native Swedes are more insulin resistant, which can contribute to atherosclerosis. Quantitative first pass perfusion (qFPP) using cardiovascular magnetic resonance (CMR) can detect early signs of cardiovascular disease (CVD). The aim was to study if myocardial perfusion differs between healthy male Middle Eastern immigrants and native male Swedes. Eighteen Iraqi- and twelve Swedish born controls, all males, never smokers with no CVD risk factors were included. Global myocardial perfusion at rest and stress was assessed using qFPP and by phase-contrast CMR imaging of coronary sinus flow. Quantitative first pass perfusion analysis (mean ± SD) demonstrated no difference at rest between Iraqi and Swedish males (0.8 ± 0.2 vs 1.0 ± 0.4 ml/min/g, P = 0.38) but lower perfusion during adenosine in Iraqi males (2.9 ± 0.7 vs 3.5 ± 0.7 ml/min/g, P = 0.02). Myocardial perfusion assessed by coronary sinus flow demonstrated similar results with no difference in resting perfusion between groups (0.7 ± 0.2 vs 0.8 ± 0.2 ml/min/g, P = 0.21) but a lower perfusion during adenosine in the Iraqi group (3.0 ± 0.2 vs 3.7 ± 0.6 ml/min/g, P = 0.01. Myocardial perfusion during adenosine stress was lower in healthy Iraqi immigrants compared to Swedish controls suggesting impaired microvascular function and risk of underestimating CVD risk in healthy individuals of Middle Eastern origin.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Male, Humans, Myocardial Perfusion Imaging/methods, Coronary Circulation, Magnetic Resonance Imaging, Cine/methods, Sweden, Vasodilator Agents, Predictive Value of Tests, Adenosine, Magnetic Resonance Spectroscopy, Risk Factors, Emigrants and Immigrants, Perfusion
in
Scientific Reports
volume
12
issue
1
article number
18237
pages
9 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85140927656
  • pmid:36309585
ISSN
2045-2322
DOI
10.1038/s41598-022-23131-x
language
English
LU publication?
yes
id
db4f5bbe-0149-4e52-bc32-5ae32af65633
date added to LUP
2022-12-01 12:23:18
date last changed
2024-06-13 20:49:57
@article{db4f5bbe-0149-4e52-bc32-5ae32af65633,
  abstract     = {{<p>Middle Eastern immigrants constitute a growing proportion of the European population and compared to native Swedes are more insulin resistant, which can contribute to atherosclerosis. Quantitative first pass perfusion (qFPP) using cardiovascular magnetic resonance (CMR) can detect early signs of cardiovascular disease (CVD). The aim was to study if myocardial perfusion differs between healthy male Middle Eastern immigrants and native male Swedes. Eighteen Iraqi- and twelve Swedish born controls, all males, never smokers with no CVD risk factors were included. Global myocardial perfusion at rest and stress was assessed using qFPP and by phase-contrast CMR imaging of coronary sinus flow. Quantitative first pass perfusion analysis (mean ± SD) demonstrated no difference at rest between Iraqi and Swedish males (0.8 ± 0.2 vs 1.0 ± 0.4 ml/min/g, P = 0.38) but lower perfusion during adenosine in Iraqi males (2.9 ± 0.7 vs 3.5 ± 0.7 ml/min/g, P = 0.02). Myocardial perfusion assessed by coronary sinus flow demonstrated similar results with no difference in resting perfusion between groups (0.7 ± 0.2 vs 0.8 ± 0.2 ml/min/g, P = 0.21) but a lower perfusion during adenosine in the Iraqi group (3.0 ± 0.2 vs 3.7 ± 0.6 ml/min/g, P = 0.01. Myocardial perfusion during adenosine stress was lower in healthy Iraqi immigrants compared to Swedish controls suggesting impaired microvascular function and risk of underestimating CVD risk in healthy individuals of Middle Eastern origin.</p>}},
  author       = {{Jablonowski, Robert and Bennet, Louise and Engblom, Henrik and Aletras, Anthony H and Xue, Hui and Kellman, Peter and Carlsson, Marcus and Arheden, Håkan}},
  issn         = {{2045-2322}},
  keywords     = {{Male; Humans; Myocardial Perfusion Imaging/methods; Coronary Circulation; Magnetic Resonance Imaging, Cine/methods; Sweden; Vasodilator Agents; Predictive Value of Tests; Adenosine; Magnetic Resonance Spectroscopy; Risk Factors; Emigrants and Immigrants; Perfusion}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Quantitative myocardial perfusion during stress using CMR is impaired in healthy Middle Eastern immigrants without CV risk factors}},
  url          = {{http://dx.doi.org/10.1038/s41598-022-23131-x}},
  doi          = {{10.1038/s41598-022-23131-x}},
  volume       = {{12}},
  year         = {{2022}},
}