Effect of single-dose DPP-4 inhibitor sitagliptin on β-cell function and incretin hormone secretion after meal ingestion in healthy volunteers and drug-naïve, well-controlled type 2 diabetes subjects
(2018) In Diabetes, Obesity and Metabolism 20(4). p.1080-1085- Abstract
To explore the effects of a single dose of the DPP-4 inhibitor sitagliptin on glucose-standardized insulin secretion and β-cell glucose sensitivity after meal ingestion, 12 healthy and 12 drug-naïve, well-controlled type 2 diabetes (T2D) subjects (mean HbA1c 43mmol/mol, 6.2%) received sitagliptin (100mg) or placebo before a meal (525kcal). β-cell function was measured as the insulin secretory rate at a standardized glucose concentration and the β-cell glucose sensitivity (the slope between glucose and insulin secretory rate). Incretin levels were also monitored. Sitagliptin increased standardized insulin secretion, in both healthy and T2D subjects, compared to placebo, but without increasing β-cell glucose sensitivity. Sitagliptin also... (More)
To explore the effects of a single dose of the DPP-4 inhibitor sitagliptin on glucose-standardized insulin secretion and β-cell glucose sensitivity after meal ingestion, 12 healthy and 12 drug-naïve, well-controlled type 2 diabetes (T2D) subjects (mean HbA1c 43mmol/mol, 6.2%) received sitagliptin (100mg) or placebo before a meal (525kcal). β-cell function was measured as the insulin secretory rate at a standardized glucose concentration and the β-cell glucose sensitivity (the slope between glucose and insulin secretory rate). Incretin levels were also monitored. Sitagliptin increased standardized insulin secretion, in both healthy and T2D subjects, compared to placebo, but without increasing β-cell glucose sensitivity. Sitagliptin also increased active glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) and reduced total (reflecting the secretion) GIP, but not total GLP-1 levels. We conclude that a single dose of DPP-4 inhibition induces dissociated effects on different aspects of β-cell function and incretin hormones after meal ingestion in both healthy and well-controlled T2D subjects.
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- author
- Alsalim, Wathik LU ; Göransson, Olga LU ; Carr, Richard D. ; Bizzotto, Roberto ; Tura, Andrea ; Pacini, Giovanni ; Mari, Andrea and Ahrén, Bo LU
- organization
- publishing date
- 2018-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Beta cell function, DPP-4 inhibitor, Incretins, Insulin secretion, Sitagliptin, Type 2 diabetes
- in
- Diabetes, Obesity and Metabolism
- volume
- 20
- issue
- 4
- pages
- 1080 - 1085
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85040723345
- pmid:29227575
- ISSN
- 1462-8902
- DOI
- 10.1111/dom.13192
- language
- English
- LU publication?
- yes
- id
- dc12f31c-1b02-49d0-93ee-f7d1bb654345
- date added to LUP
- 2018-02-26 17:14:47
- date last changed
- 2024-09-16 17:43:27
@article{dc12f31c-1b02-49d0-93ee-f7d1bb654345, abstract = {{<p>To explore the effects of a single dose of the DPP-4 inhibitor sitagliptin on glucose-standardized insulin secretion and β-cell glucose sensitivity after meal ingestion, 12 healthy and 12 drug-naïve, well-controlled type 2 diabetes (T2D) subjects (mean HbA1c 43mmol/mol, 6.2%) received sitagliptin (100mg) or placebo before a meal (525kcal). β-cell function was measured as the insulin secretory rate at a standardized glucose concentration and the β-cell glucose sensitivity (the slope between glucose and insulin secretory rate). Incretin levels were also monitored. Sitagliptin increased standardized insulin secretion, in both healthy and T2D subjects, compared to placebo, but without increasing β-cell glucose sensitivity. Sitagliptin also increased active glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) and reduced total (reflecting the secretion) GIP, but not total GLP-1 levels. We conclude that a single dose of DPP-4 inhibition induces dissociated effects on different aspects of β-cell function and incretin hormones after meal ingestion in both healthy and well-controlled T2D subjects.</p>}}, author = {{Alsalim, Wathik and Göransson, Olga and Carr, Richard D. and Bizzotto, Roberto and Tura, Andrea and Pacini, Giovanni and Mari, Andrea and Ahrén, Bo}}, issn = {{1462-8902}}, keywords = {{Beta cell function; DPP-4 inhibitor; Incretins; Insulin secretion; Sitagliptin; Type 2 diabetes}}, language = {{eng}}, number = {{4}}, pages = {{1080--1085}}, publisher = {{Wiley-Blackwell}}, series = {{Diabetes, Obesity and Metabolism}}, title = {{Effect of single-dose DPP-4 inhibitor sitagliptin on β-cell function and incretin hormone secretion after meal ingestion in healthy volunteers and drug-naïve, well-controlled type 2 diabetes subjects}}, url = {{http://dx.doi.org/10.1111/dom.13192}}, doi = {{10.1111/dom.13192}}, volume = {{20}}, year = {{2018}}, }