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Seamless integration of target-controlled infusion and closed-loop anesthesia

Wahlquist, Ylva LU and Soltesz, Kristian LU orcid (2025)
Abstract
The anesthetic drug propofol is commonly used to control hypnotic depth (suppression of awareness) in patients undergoing surgery or intensive care. In addition to manual titration, a model-based open-loop feed-forward strategy called target-controlled infusion (TCI) has attained some clinical popularity. Research on closed-loop control, with awareness estimates derived from an electroencephalogram (EEG), has proven feasible through several extensive clinical studies over the past decades. While TCI is vulnerable to model imperfections, closed-loop control is susceptible to corrupt measurements. By combining Kalman-filter-based state estimation with model predictive control (MPC), we introduce a novel anesthetic dosing regimen that can... (More)
The anesthetic drug propofol is commonly used to control hypnotic depth (suppression of awareness) in patients undergoing surgery or intensive care. In addition to manual titration, a model-based open-loop feed-forward strategy called target-controlled infusion (TCI) has attained some clinical popularity. Research on closed-loop control, with awareness estimates derived from an electroencephalogram (EEG), has proven feasible through several extensive clinical studies over the past decades. While TCI is vulnerable to model imperfections, closed-loop control is susceptible to corrupt measurements. By combining Kalman-filter-based state estimation with model predictive control (MPC), we introduce a novel anesthetic dosing regimen that can transition seamlessly between TCI and closed-lloop control, thus constituting an adequate trade-off between model and measurement reliance. We introduce this regimen and provide a realistic simulation example that highlights its strengths compared to pure TCI or closed-loop control of propofol infusion. (Less)
Please use this url to cite or link to this publication:
author
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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
in press
subject
host publication
The 2025 American Control Conference (ACC)
project
Hemodynamic Stabilization
language
English
LU publication?
yes
id
dd633fff-6717-46b8-b382-53419b4e3596
date added to LUP
2024-09-27 10:51:17
date last changed
2025-04-04 14:55:38
@inproceedings{dd633fff-6717-46b8-b382-53419b4e3596,
  abstract     = {{The anesthetic drug propofol is commonly used to control hypnotic depth (suppression of awareness) in patients undergoing surgery or intensive care. In addition to manual titration, a model-based open-loop feed-forward strategy called target-controlled infusion (TCI) has attained some clinical popularity. Research on closed-loop control, with awareness estimates derived from an electroencephalogram (EEG), has proven feasible through several extensive clinical studies over the past decades. While TCI is vulnerable to model imperfections, closed-loop control is susceptible to corrupt measurements. By combining Kalman-filter-based state estimation with model predictive control (MPC), we introduce a novel anesthetic dosing regimen that can transition seamlessly between TCI and closed-lloop control, thus constituting an adequate trade-off between model and measurement reliance. We introduce this regimen and provide a realistic simulation example that highlights its strengths compared to pure TCI or closed-loop control of propofol infusion.}},
  author       = {{Wahlquist, Ylva and Soltesz, Kristian}},
  booktitle    = {{The 2025 American Control Conference (ACC)}},
  language     = {{eng}},
  title        = {{Seamless integration of target-controlled infusion and closed-loop anesthesia}},
  url          = {{https://lup.lub.lu.se/search/files/206408299/root.pdf}},
  year         = {{2025}},
}