Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function
(2021) In Cell Stem Cell 28(2). p.6-256- Abstract
HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/dd8e7d9b-f047-47cb-a732-4fb0bd762f23
- author
- Mansell, Els LU ; Sigurdsson, Valgardur LU ; Deltcheva, Elitza ; Brown, John ; James, Chela ; Miharada, Kenichi LU ; Soneji, Shamit LU ; Larsson, Jonas LU and Enver, Tariq LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aging, Hematopoietc Stem Cell, Lineage bias, Mitochondria, Mitochondrial Membrane Potential, Mitoquinol, Transcription Rate
- in
- Cell Stem Cell
- volume
- 28
- issue
- 2
- pages
- 6 - 256
- publisher
- Cell Press
- external identifiers
-
- scopus:85095443376
- pmid:33086034
- ISSN
- 1934-5909
- DOI
- 10.1016/j.stem.2020.09.018
- language
- English
- LU publication?
- yes
- additional info
- © 2020 The Authors. Published by Elsevier Inc.
- id
- dd8e7d9b-f047-47cb-a732-4fb0bd762f23
- date added to LUP
- 2020-11-16 17:04:38
- date last changed
- 2024-06-27 01:29:44
@article{dd8e7d9b-f047-47cb-a732-4fb0bd762f23, abstract = {{<p>HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.</p>}}, author = {{Mansell, Els and Sigurdsson, Valgardur and Deltcheva, Elitza and Brown, John and James, Chela and Miharada, Kenichi and Soneji, Shamit and Larsson, Jonas and Enver, Tariq}}, issn = {{1934-5909}}, keywords = {{Aging; Hematopoietc Stem Cell; Lineage bias; Mitochondria; Mitochondrial Membrane Potential; Mitoquinol; Transcription Rate}}, language = {{eng}}, number = {{2}}, pages = {{6--256}}, publisher = {{Cell Press}}, series = {{Cell Stem Cell}}, title = {{Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function}}, url = {{http://dx.doi.org/10.1016/j.stem.2020.09.018}}, doi = {{10.1016/j.stem.2020.09.018}}, volume = {{28}}, year = {{2021}}, }