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Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

Mansell, Els LU ; Sigurdsson, Valgardur LU ; Deltcheva, Elitza ; Brown, John ; James, Chela ; Miharada, Kenichi LU ; Soneji, Shamit LU ; Larsson, Jonas LU and Enver, Tariq LU (2021) In Cell Stem Cell 28(2). p.6-256
Abstract

HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aging, Hematopoietc Stem Cell, Lineage bias, Mitochondria, Mitochondrial Membrane Potential, Mitoquinol, Transcription Rate
in
Cell Stem Cell
volume
28
issue
2
pages
6 - 256
publisher
Cell Press
external identifiers
  • scopus:85095443376
  • pmid:33086034
ISSN
1934-5909
DOI
10.1016/j.stem.2020.09.018
language
English
LU publication?
yes
additional info
© 2020 The Authors. Published by Elsevier Inc.
id
dd8e7d9b-f047-47cb-a732-4fb0bd762f23
date added to LUP
2020-11-16 17:04:38
date last changed
2024-06-27 01:29:44
@article{dd8e7d9b-f047-47cb-a732-4fb0bd762f23,
  abstract     = {{<p>HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.</p>}},
  author       = {{Mansell, Els and Sigurdsson, Valgardur and Deltcheva, Elitza and Brown, John and James, Chela and Miharada, Kenichi and Soneji, Shamit and Larsson, Jonas and Enver, Tariq}},
  issn         = {{1934-5909}},
  keywords     = {{Aging; Hematopoietc Stem Cell; Lineage bias; Mitochondria; Mitochondrial Membrane Potential; Mitoquinol; Transcription Rate}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{6--256}},
  publisher    = {{Cell Press}},
  series       = {{Cell Stem Cell}},
  title        = {{Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function}},
  url          = {{http://dx.doi.org/10.1016/j.stem.2020.09.018}},
  doi          = {{10.1016/j.stem.2020.09.018}},
  volume       = {{28}},
  year         = {{2021}},
}