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Genetic predisposition, parity, age at first childbirth and risk for breast cancer

Butt, Salma LU ; Harlid, Sophia LU ; Borgquist, Signe LU ; Ivarsson, Malin; Landberg, Göran; Dillner, Joakim LU ; Carlson, Joyce LU and Manjer, Jonas LU (2012) In BMC Research Notes 5.
Abstract

Background: Recent studies have identified several single-nucleotide polymorphisms (SNPs) associated with the risk of breast cancer and parity and age at first childbirth are well established and important risk factors for breast cancer. The aim of the present study was to examine the interaction between these environmental factors and genetic variants on breast cancer risk. Methods: The Malmö Diet and Cancer Study (MDCS) included 17 035 female participants, from which 728 incident breast cancer cases were matched to 1448 controls. The associations between 14 SNPs and breast cancer risk were investigated in different strata of parity and age at first childbirth. A logistic regression analysis for the per allele risk, adjusted for... (More)

Background: Recent studies have identified several single-nucleotide polymorphisms (SNPs) associated with the risk of breast cancer and parity and age at first childbirth are well established and important risk factors for breast cancer. The aim of the present study was to examine the interaction between these environmental factors and genetic variants on breast cancer risk. Methods: The Malmö Diet and Cancer Study (MDCS) included 17 035 female participants, from which 728 incident breast cancer cases were matched to 1448 controls. The associations between 14 SNPs and breast cancer risk were investigated in different strata of parity and age at first childbirth. A logistic regression analysis for the per allele risk, adjusted for potential confounders yielded odds ratios (OR) with 95% confidence intervals (CI). Results: Six of the previously identified SNPs showed a statistically significant association with breast cancer risk: rs2981582 (FGFR2), rs3803662 (TNRC9), rs12443621 (TNRC9), rs889312 (MAP3K1), rs3817198 (LSP1) and rs2107425 (H19). We could not find any statistically significant interaction between the effects of tested SNPs and parity/age at first childbirth on breast cancer risk after adjusting for multiple comparisons. Conclusions: The results of this study are in agreement with previous studies of null interactions between tested SNPs and parity/age at first childbirth with regard to breast cancer risk.

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organization
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publication status
published
subject
in
BMC Research Notes
volume
5
publisher
BioMed Central
external identifiers
  • scopus:84864752403
ISSN
1756-0500
DOI
10.1186/1756-0500-5-414
language
English
LU publication?
yes
id
dea4d02a-df5e-4c17-895f-a05fc3752d18
date added to LUP
2019-03-13 09:51:14
date last changed
2019-04-30 04:09:22
@article{dea4d02a-df5e-4c17-895f-a05fc3752d18,
  abstract     = {<p>Background: Recent studies have identified several single-nucleotide polymorphisms (SNPs) associated with the risk of breast cancer and parity and age at first childbirth are well established and important risk factors for breast cancer. The aim of the present study was to examine the interaction between these environmental factors and genetic variants on breast cancer risk. Methods: The Malmö Diet and Cancer Study (MDCS) included 17 035 female participants, from which 728 incident breast cancer cases were matched to 1448 controls. The associations between 14 SNPs and breast cancer risk were investigated in different strata of parity and age at first childbirth. A logistic regression analysis for the per allele risk, adjusted for potential confounders yielded odds ratios (OR) with 95% confidence intervals (CI). Results: Six of the previously identified SNPs showed a statistically significant association with breast cancer risk: rs2981582 (FGFR2), rs3803662 (TNRC9), rs12443621 (TNRC9), rs889312 (MAP3K1), rs3817198 (LSP1) and rs2107425 (H19). We could not find any statistically significant interaction between the effects of tested SNPs and parity/age at first childbirth on breast cancer risk after adjusting for multiple comparisons. Conclusions: The results of this study are in agreement with previous studies of null interactions between tested SNPs and parity/age at first childbirth with regard to breast cancer risk.</p>},
  articleno    = {414},
  author       = {Butt, Salma and Harlid, Sophia and Borgquist, Signe and Ivarsson, Malin and Landberg, Göran and Dillner, Joakim and Carlson, Joyce and Manjer, Jonas},
  issn         = {1756-0500},
  language     = {eng},
  month        = {08},
  publisher    = {BioMed Central},
  series       = {BMC Research Notes},
  title        = {Genetic predisposition, parity, age at first childbirth and risk for breast cancer},
  url          = {http://dx.doi.org/10.1186/1756-0500-5-414},
  volume       = {5},
  year         = {2012},
}