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The DGAT1 K232A mutation is not solely responsible for the milk production quantitative trait locus on the bovine chromosome 14

Bennewitz, J.; Reinsch, N.; Paul, S.; Looft, C.; Kaupe, B.; Weimann, C.; Erhardt, G.; Thaller, G.; Kühn, Ch and Schwerin, M., et al. (2004) In Journal of Dairy Science 87(2). p.431-442
Abstract

The gene, acyl-CoA:diacylglycerol acyltransferase1 (DGAT1), was recently identified as the one underlying the quantitative trait locus (QTL) for milk production traits in the centromeric region of the bovine chromosome 14. Until now, 2 alleles, the lysine variant (increasing fat yield, fat and protein percentage) and the alanine variant (increasing protein and milk yield), were postulated at DGAT1. This study investigated whether the diallelic DGAT1 polymorphism is responsible for all the genetic variation at the centromeric region of this chromosome for milk, fat, and protein yield and fat and protein percentage. A statistical model was applied to a granddaughter design to analyze 16 German Holstein families. The model included the... (More)

The gene, acyl-CoA:diacylglycerol acyltransferase1 (DGAT1), was recently identified as the one underlying the quantitative trait locus (QTL) for milk production traits in the centromeric region of the bovine chromosome 14. Until now, 2 alleles, the lysine variant (increasing fat yield, fat and protein percentage) and the alanine variant (increasing protein and milk yield), were postulated at DGAT1. This study investigated whether the diallelic DGAT1 polymorphism is responsible for all the genetic variation at the centromeric region of this chromosome for milk, fat, and protein yield and fat and protein percentage. A statistical model was applied to a granddaughter design to analyze 16 German Holstein families. The model included the diallelic DGAT1 effect and the QTL transition probability estimated for each chromosomal position by a multiple marker approach. Because the regression coefficient of this probability was corrected for the diallelic DGAT1 polymorphism, it represented a putative conditional QTL effect. The effect of the DGAT1 gene was always highly significant. The conditional QTL effect was significant genomewise for fat percentage at the proximal end of the chromosome and for protein percentage at a more distal chromosomal region. Additional chromosomewise significance was found for fat and protein yield. Our results suggest an additional source of genetic variance on this chromosome for these traits; either one or more additional alleles segregating at DGAT1 that were not previously detected, a second quantitative trait locus affecting these traits, or both.

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publication status
published
keywords
Dairy cattle, DGAT1, Multiple allele, Quantitative trait locus
in
Journal of Dairy Science
volume
87
issue
2
pages
12 pages
publisher
American Dairy Science Association
external identifiers
  • scopus:17144473304
ISSN
0022-0302
DOI
10.3168/jds.S0022-0302(04)73182-3
language
English
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no
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df0aa931-f84f-449b-ae79-219e570aceb4
date added to LUP
2018-10-10 13:36:31
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2018-11-21 21:42:18
@article{df0aa931-f84f-449b-ae79-219e570aceb4,
  abstract     = {<p>The gene, acyl-CoA:diacylglycerol acyltransferase1 (DGAT1), was recently identified as the one underlying the quantitative trait locus (QTL) for milk production traits in the centromeric region of the bovine chromosome 14. Until now, 2 alleles, the lysine variant (increasing fat yield, fat and protein percentage) and the alanine variant (increasing protein and milk yield), were postulated at DGAT1. This study investigated whether the diallelic DGAT1 polymorphism is responsible for all the genetic variation at the centromeric region of this chromosome for milk, fat, and protein yield and fat and protein percentage. A statistical model was applied to a granddaughter design to analyze 16 German Holstein families. The model included the diallelic DGAT1 effect and the QTL transition probability estimated for each chromosomal position by a multiple marker approach. Because the regression coefficient of this probability was corrected for the diallelic DGAT1 polymorphism, it represented a putative conditional QTL effect. The effect of the DGAT1 gene was always highly significant. The conditional QTL effect was significant genomewise for fat percentage at the proximal end of the chromosome and for protein percentage at a more distal chromosomal region. Additional chromosomewise significance was found for fat and protein yield. Our results suggest an additional source of genetic variance on this chromosome for these traits; either one or more additional alleles segregating at DGAT1 that were not previously detected, a second quantitative trait locus affecting these traits, or both.</p>},
  author       = {Bennewitz, J. and Reinsch, N. and Paul, S. and Looft, C. and Kaupe, B. and Weimann, C. and Erhardt, G. and Thaller, G. and Kühn, Ch and Schwerin, M. and Thomsen, H. and Reinhardt, F. and Reents, R. and Kalm, E.},
  issn         = {0022-0302},
  keyword      = {Dairy cattle,DGAT1,Multiple allele,Quantitative trait locus},
  language     = {eng},
  month        = {01},
  number       = {2},
  pages        = {431--442},
  publisher    = {American Dairy Science Association},
  series       = {Journal of Dairy Science},
  title        = {The DGAT1 K232A mutation is not solely responsible for the milk production quantitative trait locus on the bovine chromosome 14},
  url          = {http://dx.doi.org/10.3168/jds.S0022-0302(04)73182-3},
  volume       = {87},
  year         = {2004},
}