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Survival in endometrial cancer in relation to minimally invasive surgery or open surgery – a Swedish Gynecologic Cancer Group (SweGCG) study

Borgfeldt, Christer LU ; Holmberg, Erik ; Marcickiewicz, Janusz ; Stålberg, Karin ; Tholander, Bengt ; Lundqvist, Elisabeth Åvall ; Flöter-Rådestad, Angelique ; Bjurberg, Maria LU ; Dahm-Kähler, Pernilla and Hellman, Kristina , et al. (2021) In BMC Cancer 21(1).
Abstract

Background: The aim of this study was to analyze overall survival in endometrial cancer patients’ FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy). Methods: A population-based retrospective study of 7275 endometrial cancer patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed from 2010 to 2018. Cox proportional hazard models were used in univariable and multivariable survival analyses. Results: In univariable analysis open surgery was associated with worse overall survival compared with MIS hazard ratio, HR, 1.39 (95% CI 1.18–1.63) while in the multivariable analysis, surgical approach (MIS vs open surgery) was not associated with overall survival... (More)

Background: The aim of this study was to analyze overall survival in endometrial cancer patients’ FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy). Methods: A population-based retrospective study of 7275 endometrial cancer patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed from 2010 to 2018. Cox proportional hazard models were used in univariable and multivariable survival analyses. Results: In univariable analysis open surgery was associated with worse overall survival compared with MIS hazard ratio, HR, 1.39 (95% CI 1.18–1.63) while in the multivariable analysis, surgical approach (MIS vs open surgery) was not associated with overall survival after adjustment for known risk factors (HR 1.12, 95% CI 0.95–1.32). Higher FIGO stage, non-endometrioid histology, non-diploid tumors, lymphovascular space invasion and increasing age were independent risk factors for overall survival. Conclusion: The minimal invasive or open surgical approach did not show any impact on survival for patients with endometrial cancer stages I-III when known prognostic risk factors were included in the multivariable analyses.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Endometrial cancer, Minimally invasive surgery, Risk factors, Survival
in
BMC Cancer
volume
21
issue
1
article number
658
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85107198254
  • pmid:34078319
ISSN
1471-2407
DOI
10.1186/s12885-021-08289-3
language
English
LU publication?
yes
id
df43452c-55c9-466d-8d1a-30f512b612d0
date added to LUP
2021-06-18 11:31:00
date last changed
2024-06-15 12:45:45
@article{df43452c-55c9-466d-8d1a-30f512b612d0,
  abstract     = {{<p>Background: The aim of this study was to analyze overall survival in endometrial cancer patients’ FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy). Methods: A population-based retrospective study of 7275 endometrial cancer patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed from 2010 to 2018. Cox proportional hazard models were used in univariable and multivariable survival analyses. Results: In univariable analysis open surgery was associated with worse overall survival compared with MIS hazard ratio, HR, 1.39 (95% CI 1.18–1.63) while in the multivariable analysis, surgical approach (MIS vs open surgery) was not associated with overall survival after adjustment for known risk factors (HR 1.12, 95% CI 0.95–1.32). Higher FIGO stage, non-endometrioid histology, non-diploid tumors, lymphovascular space invasion and increasing age were independent risk factors for overall survival. Conclusion: The minimal invasive or open surgical approach did not show any impact on survival for patients with endometrial cancer stages I-III when known prognostic risk factors were included in the multivariable analyses.</p>}},
  author       = {{Borgfeldt, Christer and Holmberg, Erik and Marcickiewicz, Janusz and Stålberg, Karin and Tholander, Bengt and Lundqvist, Elisabeth Åvall and Flöter-Rådestad, Angelique and Bjurberg, Maria and Dahm-Kähler, Pernilla and Hellman, Kristina and Hjerpe, Elisabet and Kjölhede, Preben and Rosenberg, Per and Högberg, Thomas}},
  issn         = {{1471-2407}},
  keywords     = {{Endometrial cancer; Minimally invasive surgery; Risk factors; Survival}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Cancer}},
  title        = {{Survival in endometrial cancer in relation to minimally invasive surgery or open surgery – a Swedish Gynecologic Cancer Group (SweGCG) study}},
  url          = {{http://dx.doi.org/10.1186/s12885-021-08289-3}},
  doi          = {{10.1186/s12885-021-08289-3}},
  volume       = {{21}},
  year         = {{2021}},
}