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Risks of breast, endometrial, and ovarian cancers after twin births

Ji, Jianguang LU ; Försti, Asta LU ; Sundquist, Jan LU and Hemminki, Kari LU (2007) In Endocrine-Related Cancer 14(3). p.11-703
Abstract

The concentrations of endogenous hormones differ between women with twin and singleton births, with a possible influence on the risk of cancer. We used the nationwide Swedish Family-Cancer Database, including 30,409 women with a twin birth, to examine the subsequent risks of breast, endometrial, and ovarian cancers. Relative risks (RRs) were calculated in a log-linear Poisson regression model of person-years as offset. Cancer data were retrieved from the Swedish Cancer Registry; a total of 1010, 210, and 174 women were diagnosed with breast, endometrial, and ovarian cancers respectively, after a twin birth. A significant decrease in the risk of breast cancer was noted among women with a twin birth compared with women with a singleton... (More)

The concentrations of endogenous hormones differ between women with twin and singleton births, with a possible influence on the risk of cancer. We used the nationwide Swedish Family-Cancer Database, including 30,409 women with a twin birth, to examine the subsequent risks of breast, endometrial, and ovarian cancers. Relative risks (RRs) were calculated in a log-linear Poisson regression model of person-years as offset. Cancer data were retrieved from the Swedish Cancer Registry; a total of 1010, 210, and 174 women were diagnosed with breast, endometrial, and ovarian cancers respectively, after a twin birth. A significant decrease in the risk of breast cancer was noted among women with a twin birth compared with women with a singleton birth (RR 0.85, 95% confidence interval (CI) 0.74-0.98). The protective effects were observed throughout the intervals after last pregnancy and they were strongest shortly after the last pregnancy in women who delivered a twin birth before 30 years of age. Twin birth did not change the risk of endometrial cancer (1.08, 95% CI 0.79-1.47) but the RR was increased for women with the number of pregnancies > or =4 (1.39, 95% CI 1.11-1.76). The RR for ovarian cancer was 0.95 (95% CI 0.79-1.15). Our study showed that twin births significantly reduced the subsequent risk of breast cancer. However, the associations of twin births with endometrial and ovarian cancers were not substantial.

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author
publishing date
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publication status
published
subject
keywords
Adolescent, Adult, Age Factors, Breast Neoplasms/epidemiology, Cohort Studies, Databases, Factual, Endometrial Neoplasms/epidemiology, Female, Gravidity, Humans, Middle Aged, Ovarian Neoplasms/epidemiology, Pregnancy, Pregnancy, Multiple, Risk Factors, Twins
in
Endocrine-Related Cancer
volume
14
issue
3
pages
11 - 703
publisher
Society for Endocrinology
external identifiers
  • scopus:35948956748
ISSN
1351-0088
DOI
10.1677/ERC-07-0088
language
English
LU publication?
no
id
e0108e7f-b286-47a8-b557-6d1ac23583cd
date added to LUP
2019-01-30 10:51:47
date last changed
2019-03-08 02:17:09
@article{e0108e7f-b286-47a8-b557-6d1ac23583cd,
  abstract     = {<p>The concentrations of endogenous hormones differ between women with twin and singleton births, with a possible influence on the risk of cancer. We used the nationwide Swedish Family-Cancer Database, including 30,409 women with a twin birth, to examine the subsequent risks of breast, endometrial, and ovarian cancers. Relative risks (RRs) were calculated in a log-linear Poisson regression model of person-years as offset. Cancer data were retrieved from the Swedish Cancer Registry; a total of 1010, 210, and 174 women were diagnosed with breast, endometrial, and ovarian cancers respectively, after a twin birth. A significant decrease in the risk of breast cancer was noted among women with a twin birth compared with women with a singleton birth (RR 0.85, 95% confidence interval (CI) 0.74-0.98). The protective effects were observed throughout the intervals after last pregnancy and they were strongest shortly after the last pregnancy in women who delivered a twin birth before 30 years of age. Twin birth did not change the risk of endometrial cancer (1.08, 95% CI 0.79-1.47) but the RR was increased for women with the number of pregnancies &gt; or =4 (1.39, 95% CI 1.11-1.76). The RR for ovarian cancer was 0.95 (95% CI 0.79-1.15). Our study showed that twin births significantly reduced the subsequent risk of breast cancer. However, the associations of twin births with endometrial and ovarian cancers were not substantial.</p>},
  author       = {Ji, Jianguang and Försti, Asta and Sundquist, Jan and Hemminki, Kari},
  issn         = {1351-0088},
  keyword      = {Adolescent,Adult,Age Factors,Breast Neoplasms/epidemiology,Cohort Studies,Databases, Factual,Endometrial Neoplasms/epidemiology,Female,Gravidity,Humans,Middle Aged,Ovarian Neoplasms/epidemiology,Pregnancy,Pregnancy, Multiple,Risk Factors,Twins},
  language     = {eng},
  number       = {3},
  pages        = {11--703},
  publisher    = {Society for Endocrinology},
  series       = {Endocrine-Related Cancer},
  title        = {Risks of breast, endometrial, and ovarian cancers after twin births},
  url          = {http://dx.doi.org/10.1677/ERC-07-0088},
  volume       = {14},
  year         = {2007},
}