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Acute phase proteins as prospective risk markers for arterial stiffness : The Malmö Diet and Cancer cohort

Muhammad, Iram Faqir LU ; Borné, Yan LU ; Östling, Gerd LU ; Kennbäck, Cecilia ; Gottsäter, Mikael LU ; Persson, Margaretha LU orcid ; Nilsson, Peter M. LU and Engström, Gunnar LU (2017) In PLoS ONE 12(7).
Abstract

Background and objectives: Arterial stiffness plays a significant role in the development and progression of adverse cardiovascular events and all-cause mortality. This observational study aims to explore the relationship between six acute phase proteins namely, ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin, complement C3 and C-reactive protein (CRP), and carotid-femoral pulse wave velocity (c-f PWV) in a population-based cohort, and to also explore the effect of low-grade inflammation on the relationship between diabetes and c-f PWV. Method: The study consisted of participants from the Malmö Diet and Cancer study with data from baseline examinations (1991–1994) and follow-up examinations (2007–2012). Arterial stiffness... (More)

Background and objectives: Arterial stiffness plays a significant role in the development and progression of adverse cardiovascular events and all-cause mortality. This observational study aims to explore the relationship between six acute phase proteins namely, ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin, complement C3 and C-reactive protein (CRP), and carotid-femoral pulse wave velocity (c-f PWV) in a population-based cohort, and to also explore the effect of low-grade inflammation on the relationship between diabetes and c-f PWV. Method: The study consisted of participants from the Malmö Diet and Cancer study with data from baseline examinations (1991–1994) and follow-up examinations (2007–2012). Arterial stiffness was measured at follow-up by determining c-f PWV. After excluding participants with missing data, the total study population included 2338 subjects. General linear models were used to assess the relationship between baseline acute phase proteins and c-f PWV. Results: After adjusting for traditional risk factors the participants in the 4th quartile vs 1st quartile of alpha-1-antitrypsin (geometric mean: 10.32 m/s vs 10.04 m/s) (<0.05), C3 (10.35 m/s vs 10.06 m/s) (p<0.05) and CRP (10.37 m/s vs 9.96 m/s) (<0.001) showed significant association with c-f PWV. Diabetes at follow-up was also associated with high c-f PWV, however, this relationship was independent of low grade inflammation. Conclusion: Alpha-1-antitrypsin, C3 and CRP are associated with arterial stiffness. The results indicate that low grade inflammation is associated with arterial stiffness in addition to established cardiovascular risk factors.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
12
issue
7
article number
e0181718
publisher
Public Library of Science (PLoS)
external identifiers
  • pmid:28759613
  • wos:000406761600023
  • scopus:85026349020
ISSN
1932-6203
DOI
10.1371/journal.pone.0181718
language
English
LU publication?
yes
id
e0429f51-91bc-43d5-8275-5315622ccd3f
date added to LUP
2017-08-25 13:52:55
date last changed
2024-10-14 11:42:07
@article{e0429f51-91bc-43d5-8275-5315622ccd3f,
  abstract     = {{<p>Background and objectives: Arterial stiffness plays a significant role in the development and progression of adverse cardiovascular events and all-cause mortality. This observational study aims to explore the relationship between six acute phase proteins namely, ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin, complement C3 and C-reactive protein (CRP), and carotid-femoral pulse wave velocity (c-f PWV) in a population-based cohort, and to also explore the effect of low-grade inflammation on the relationship between diabetes and c-f PWV. Method: The study consisted of participants from the Malmö Diet and Cancer study with data from baseline examinations (1991–1994) and follow-up examinations (2007–2012). Arterial stiffness was measured at follow-up by determining c-f PWV. After excluding participants with missing data, the total study population included 2338 subjects. General linear models were used to assess the relationship between baseline acute phase proteins and c-f PWV. Results: After adjusting for traditional risk factors the participants in the 4<sup>th</sup> quartile vs 1<sup>st</sup> quartile of alpha-1-antitrypsin (geometric mean: 10.32 m/s vs 10.04 m/s) (&lt;0.05), C3 (10.35 m/s vs 10.06 m/s) (p&lt;0.05) and CRP (10.37 m/s vs 9.96 m/s) (&lt;0.001) showed significant association with c-f PWV. Diabetes at follow-up was also associated with high c-f PWV, however, this relationship was independent of low grade inflammation. Conclusion: Alpha-1-antitrypsin, C3 and CRP are associated with arterial stiffness. The results indicate that low grade inflammation is associated with arterial stiffness in addition to established cardiovascular risk factors.</p>}},
  author       = {{Muhammad, Iram Faqir and Borné, Yan and Östling, Gerd and Kennbäck, Cecilia and Gottsäter, Mikael and Persson, Margaretha and Nilsson, Peter M. and Engström, Gunnar}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Acute phase proteins as prospective risk markers for arterial stiffness : The Malmö Diet and Cancer cohort}},
  url          = {{http://dx.doi.org/10.1371/journal.pone.0181718}},
  doi          = {{10.1371/journal.pone.0181718}},
  volume       = {{12}},
  year         = {{2017}},
}