Familial risk for gastric carcinoma : An updated study from Sweden
Hemminki, K. LU ; Sundquist, J. LU and Ji, J. LU
(2007)
In British Journal of Cancer
96(8).
p.1272-1277
- Abstract
Reliable data on familial risks are important for clinical counselling and cancer genetics. However, the estimates of familial risk of gastric cancer vary widely. We examined the risk of familial gastric cancer using the updated Swedish Family-Cancer Database with 5358 patients among offspring and 36 486 patients among parents. There were 133 families with one parent and one offspring diagnosed with gastric cancer, and 20 families with two affected offspring. Familial standardised incidence ratios (SIRs) were 1.63 and 2.93 when parents and siblings presented with gastric cancer, respectively. The high sibling risk was owing to cancer in the corpus (SIR 7.28). The SIR for cardia cancer was 1.54 when parents were diagnosed with any... (More)
Reliable data on familial risks are important for clinical counselling and cancer genetics. However, the estimates of familial risk of gastric cancer vary widely. We examined the risk of familial gastric cancer using the updated Swedish Family-Cancer Database with 5358 patients among offspring and 36 486 patients among parents. There were 133 families with one parent and one offspring diagnosed with gastric cancer, and 20 families with two affected offspring. Familial standardised incidence ratios (SIRs) were 1.63 and 2.93 when parents and siblings presented with gastric cancer, respectively. The high sibling risk was owing to cancer in the corpus (SIR 7.28). The SIR for cardia cancer was 1.54 when parents were diagnosed with any gastric cancer. Cardia cancer associated with oesophageal cancer, particularly with oesophageal adenocarcinoma. Among specific histologies, signet ring cancer showed an increase. A few associations were noted for discordant sites, including the urinary bladder and the endometrium. H. pylori infection, although not measured in the present study, is probably an important risk factor for the high sibling risk of corpus cancer. Familial clustering of cardia cancer is independent of H. pylori infection, and may have a genetic basis. The familial association of cardia cancer with oesophageal adenocarcinoma may provide aetiological clues.
(Less)
- author
- Hemminki, K.
LU
; Sundquist, J.
LU
and Ji, J.
LU
- publishing date
- 2007-04-23
- type
- Contribution to journal
- publication status
- published
- keywords
- Cardia cancer, Corpus cancer, Familial risk, Gastric cancer
- in
- British Journal of Cancer
- volume
- 96
- issue
- 8
- pages
- 6 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:34247181201
- pmid:17406355
- ISSN
- 0007-0920
- DOI
- 10.1038/sj.bjc.6603722
- language
- English
- LU publication?
- no
- id
- e042d651-b0a9-44ea-b6d6-bbf4e627a879
- date added to LUP
- 2019-01-30 10:19:43
- date last changed
- 2024-04-15 21:47:30
@article{e042d651-b0a9-44ea-b6d6-bbf4e627a879,
abstract = {{<p>Reliable data on familial risks are important for clinical counselling and cancer genetics. However, the estimates of familial risk of gastric cancer vary widely. We examined the risk of familial gastric cancer using the updated Swedish Family-Cancer Database with 5358 patients among offspring and 36 486 patients among parents. There were 133 families with one parent and one offspring diagnosed with gastric cancer, and 20 families with two affected offspring. Familial standardised incidence ratios (SIRs) were 1.63 and 2.93 when parents and siblings presented with gastric cancer, respectively. The high sibling risk was owing to cancer in the corpus (SIR 7.28). The SIR for cardia cancer was 1.54 when parents were diagnosed with any gastric cancer. Cardia cancer associated with oesophageal cancer, particularly with oesophageal adenocarcinoma. Among specific histologies, signet ring cancer showed an increase. A few associations were noted for discordant sites, including the urinary bladder and the endometrium. H. pylori infection, although not measured in the present study, is probably an important risk factor for the high sibling risk of corpus cancer. Familial clustering of cardia cancer is independent of H. pylori infection, and may have a genetic basis. The familial association of cardia cancer with oesophageal adenocarcinoma may provide aetiological clues.</p>}},
author = {{Hemminki, K. and Sundquist, J. and Ji, J.}},
issn = {{0007-0920}},
keywords = {{Cardia cancer; Corpus cancer; Familial risk; Gastric cancer}},
language = {{eng}},
month = {{04}},
number = {{8}},
pages = {{1272--1277}},
publisher = {{Nature Publishing Group}},
series = {{British Journal of Cancer}},
title = {{Familial risk for gastric carcinoma : An updated study from Sweden}},
url = {{http://dx.doi.org/10.1038/sj.bjc.6603722}},
doi = {{10.1038/sj.bjc.6603722}},
volume = {{96}},
year = {{2007}},
}