Targeting Alveolar Repair in Idiopathic Pulmonary Fibrosis
Ptasinski, Victoria LU ; Stegmayr, John LU ; Belvisi, Maria G ; Wagner, Darcy E LU
and Murray, Lynne A
(2021)
In American Journal of Respiratory Cell and Molecular Biology
65(4).
p.347-347
- Abstract
Idiopathic pulmonary fibrosis is a fatal interstitial lung disease with limited therapeutic options. Current evidence suggests that IPF may be initiated by repeated epithelial injury in the distal lung followed by abnormal wound healing responses which occur due to intrinsic and extrinsic factors. Mechanisms contributing to chronic damage of the alveolar epithelium in IPF include dysregulated cellular processes such as apoptosis, senescence, abnormal activation of developmental pathways, aging, as well as genetic mutations. Therefore, targeting the regenerative capacity of the lung epithelium is an attractive approach in the development of novel therapies for IPF. Endogenous lung regeneration is a complex process involving coordinated... (More)
Idiopathic pulmonary fibrosis is a fatal interstitial lung disease with limited therapeutic options. Current evidence suggests that IPF may be initiated by repeated epithelial injury in the distal lung followed by abnormal wound healing responses which occur due to intrinsic and extrinsic factors. Mechanisms contributing to chronic damage of the alveolar epithelium in IPF include dysregulated cellular processes such as apoptosis, senescence, abnormal activation of developmental pathways, aging, as well as genetic mutations. Therefore, targeting the regenerative capacity of the lung epithelium is an attractive approach in the development of novel therapies for IPF. Endogenous lung regeneration is a complex process involving coordinated cross-talk between multiple cell types and re-establishment of a normal extracellular matrix environment. This review will describe the current knowledge of reparative epithelial progenitor cells in the alveolar region of the lung and discuss potential novel therapeutic approaches for IPF focusing on endogenous alveolar repair. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
(Less)
- author
- Ptasinski, Victoria
LU
; Stegmayr, John
LU
; Belvisi, Maria G
; Wagner, Darcy E
LU
and Murray, Lynne A
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Respiratory Cell and Molecular Biology
- volume
- 65
- issue
- 4
- pages
- 365 pages
- publisher
- American Thoracic Society
- external identifiers
-
- pmid:34129811
- scopus:85116592373
- ISSN
- 1535-4989
- DOI
- 10.1165/rcmb.2020-0476TR
- language
- English
- LU publication?
- yes
- id
- e12929fb-bc8d-42e8-b727-3711973bea1c
- date added to LUP
- 2021-07-10 15:35:37
- date last changed
- 2024-06-16 15:59:20
@article{e12929fb-bc8d-42e8-b727-3711973bea1c,
abstract = {{<p>Idiopathic pulmonary fibrosis is a fatal interstitial lung disease with limited therapeutic options. Current evidence suggests that IPF may be initiated by repeated epithelial injury in the distal lung followed by abnormal wound healing responses which occur due to intrinsic and extrinsic factors. Mechanisms contributing to chronic damage of the alveolar epithelium in IPF include dysregulated cellular processes such as apoptosis, senescence, abnormal activation of developmental pathways, aging, as well as genetic mutations. Therefore, targeting the regenerative capacity of the lung epithelium is an attractive approach in the development of novel therapies for IPF. Endogenous lung regeneration is a complex process involving coordinated cross-talk between multiple cell types and re-establishment of a normal extracellular matrix environment. This review will describe the current knowledge of reparative epithelial progenitor cells in the alveolar region of the lung and discuss potential novel therapeutic approaches for IPF focusing on endogenous alveolar repair. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).</p>}},
author = {{Ptasinski, Victoria and Stegmayr, John and Belvisi, Maria G and Wagner, Darcy E and Murray, Lynne A}},
issn = {{1535-4989}},
language = {{eng}},
number = {{4}},
pages = {{347--347}},
publisher = {{American Thoracic Society}},
series = {{American Journal of Respiratory Cell and Molecular Biology}},
title = {{Targeting Alveolar Repair in Idiopathic Pulmonary Fibrosis}},
url = {{http://dx.doi.org/10.1165/rcmb.2020-0476TR}},
doi = {{10.1165/rcmb.2020-0476TR}},
volume = {{65}},
year = {{2021}},
}