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PVC flooring at home and uptake of phthalates in pregnant women

Shu, Huan; Jönsson, Bo A.G. LU ; Gennings, Chris; Lindh, Christian H. LU ; Nånberg, Eewa and Bornehag, Carl Gustaf LU (2019) In Indoor Air 29(1). p.43-54
Abstract

Phthalates are used as plasticizers in polyvinyl chloride (PVC) materials and it is known that phthalates may migrate into the surrounding environment and then become a source for human uptake. The aim of the study was to investigate whether residential PVC flooring was related to the urinary levels of phthalate metabolites determined in pregnant women. The data were from the Swedish SELMA study where sampling was conducted during the time period 2007-2010. Spot urine samples from 1674 women at the end of the first trimester were analyzed for 14 metabolites from seven phthalates and one phthalate alternative. Data on flooring material in the kitchen and the parents’ bedrooms as well as potential confounders were collected by postal... (More)

Phthalates are used as plasticizers in polyvinyl chloride (PVC) materials and it is known that phthalates may migrate into the surrounding environment and then become a source for human uptake. The aim of the study was to investigate whether residential PVC flooring was related to the urinary levels of phthalate metabolites determined in pregnant women. The data were from the Swedish SELMA study where sampling was conducted during the time period 2007-2010. Spot urine samples from 1674 women at the end of the first trimester were analyzed for 14 metabolites from seven phthalates and one phthalate alternative. Data on flooring material in the kitchen and the parents’ bedrooms as well as potential confounders were collected by postal questionnaires at the same time as the urine samples were taken. Multiple regression modeling by least square geometric mean and weighted quantile sum regression was applied to log-transformed and creatinine-adjusted phthalate metabolite concentrations adjusted for potential confounders from questionnaire data. This study has found significantly higher urinary levels of the BBzP metabolite (MBzP) in pregnant women living in homes with PVC flooring as compared to homes with other flooring materials.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
DINCH, endocrine disrupting chemicals, phthalate, pregnant, PVC flooring, SELMA study
in
Indoor Air
volume
29
issue
1
pages
43 - 54
publisher
Wiley-Blackwell
external identifiers
  • scopus:85056330290
ISSN
0905-6947
DOI
10.1111/ina.12508
language
English
LU publication?
yes
id
e1923a72-fc3c-4775-8758-33fe2ed08e4c
date added to LUP
2018-11-23 12:55:33
date last changed
2019-01-16 12:23:36
@article{e1923a72-fc3c-4775-8758-33fe2ed08e4c,
  abstract     = {<p>Phthalates are used as plasticizers in polyvinyl chloride (PVC) materials and it is known that phthalates may migrate into the surrounding environment and then become a source for human uptake. The aim of the study was to investigate whether residential PVC flooring was related to the urinary levels of phthalate metabolites determined in pregnant women. The data were from the Swedish SELMA study where sampling was conducted during the time period 2007-2010. Spot urine samples from 1674 women at the end of the first trimester were analyzed for 14 metabolites from seven phthalates and one phthalate alternative. Data on flooring material in the kitchen and the parents’ bedrooms as well as potential confounders were collected by postal questionnaires at the same time as the urine samples were taken. Multiple regression modeling by least square geometric mean and weighted quantile sum regression was applied to log-transformed and creatinine-adjusted phthalate metabolite concentrations adjusted for potential confounders from questionnaire data. This study has found significantly higher urinary levels of the BBzP metabolite (MBzP) in pregnant women living in homes with PVC flooring as compared to homes with other flooring materials.</p>},
  author       = {Shu, Huan and Jönsson, Bo A.G. and Gennings, Chris and Lindh, Christian H. and Nånberg, Eewa and Bornehag, Carl Gustaf},
  issn         = {0905-6947},
  keyword      = {DINCH,endocrine disrupting chemicals,phthalate,pregnant,PVC flooring,SELMA study},
  language     = {eng},
  number       = {1},
  pages        = {43--54},
  publisher    = {Wiley-Blackwell},
  series       = {Indoor Air},
  title        = {PVC flooring at home and uptake of phthalates in pregnant women},
  url          = {http://dx.doi.org/10.1111/ina.12508},
  volume       = {29},
  year         = {2019},
}