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Circulating levels of growth hormone in postural orthostatic tachycardia syndrome

Johansson, Madeleine LU orcid ; Ricci, Fabrizio LU ; Schulte, Janin ; Persson, Margaretha LU orcid ; Melander, Olle LU orcid ; Sutton, Richard ; Hamrefors, Viktor LU orcid and Fedorowski, Artur LU orcid (2021) In Scientific Reports 11.
Abstract

Postural orthostatic tachycardia syndrome (POTS) is a cardiovascular autonomic disorder with poorly understood etiology and underlying pathophysiology. Since cardiovascular morbidity has been linked to growth hormone (GH), we studied GH levels in patients with POTS. We conducted an age-sex-matched case-control study in patients with POTS (age 31 ± 9 years; n = 42) and healthy controls (32 ± 9 years; n = 46). Plasma GH levels were measured using high-sensitivity chemiluminescence sandwich immunoassay. The burden of orthostatic intolerance symptoms was assessed by the Orthostatic Hypotension Questionnaire (OHQ), consisting of a symptom assessment scale (OHSA) and a daily activity scale (OHDAS). POTS patients had significantly higher... (More)

Postural orthostatic tachycardia syndrome (POTS) is a cardiovascular autonomic disorder with poorly understood etiology and underlying pathophysiology. Since cardiovascular morbidity has been linked to growth hormone (GH), we studied GH levels in patients with POTS. We conducted an age-sex-matched case-control study in patients with POTS (age 31 ± 9 years; n = 42) and healthy controls (32 ± 9 years; n = 46). Plasma GH levels were measured using high-sensitivity chemiluminescence sandwich immunoassay. The burden of orthostatic intolerance symptoms was assessed by the Orthostatic Hypotension Questionnaire (OHQ), consisting of a symptom assessment scale (OHSA) and a daily activity scale (OHDAS). POTS patients had significantly higher composite OHQ score than controls, more symptoms and less activity. Supine heart rate and diastolic blood pressure (BP), but not systolic BP, were significantly higher in POTS. Median plasma GH levels were significantly lower in POTS (0.53 ng/mL) than controls (2.33 ng/mL, p = 0.04). GH levels were inversely related to OHDAS in POTS and supine systolic BP in POTS and controls, but not heart rate neither group. POTS is associated with lower GH levels. Impairment of daily life activities is inversely related with GH in POTS. A higher supine diastolic BP is inversely associated with GH levels in POTS and healthy individuals.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Pots, Growth hormone
in
Scientific Reports
volume
11
article number
8575
publisher
Nature Publishing Group
external identifiers
  • pmid:33883597
  • scopus:85104714461
ISSN
2045-2322
DOI
10.1038/s41598-021-87983-5
language
English
LU publication?
yes
id
e1b0c9b4-c463-4b7f-acd3-8211d555c41d
date added to LUP
2021-04-23 09:48:17
date last changed
2024-04-20 05:13:51
@article{e1b0c9b4-c463-4b7f-acd3-8211d555c41d,
  abstract     = {{<p>Postural orthostatic tachycardia syndrome (POTS) is a cardiovascular autonomic disorder with poorly understood etiology and underlying pathophysiology. Since cardiovascular morbidity has been linked to growth hormone (GH), we studied GH levels in patients with POTS. We conducted an age-sex-matched case-control study in patients with POTS (age 31 ± 9 years; n = 42) and healthy controls (32 ± 9 years; n = 46). Plasma GH levels were measured using high-sensitivity chemiluminescence sandwich immunoassay. The burden of orthostatic intolerance symptoms was assessed by the Orthostatic Hypotension Questionnaire (OHQ), consisting of a symptom assessment scale (OHSA) and a daily activity scale (OHDAS). POTS patients had significantly higher composite OHQ score than controls, more symptoms and less activity. Supine heart rate and diastolic blood pressure (BP), but not systolic BP, were significantly higher in POTS. Median plasma GH levels were significantly lower in POTS (0.53 ng/mL) than controls (2.33 ng/mL, p = 0.04). GH levels were inversely related to OHDAS in POTS and supine systolic BP in POTS and controls, but not heart rate neither group. POTS is associated with lower GH levels. Impairment of daily life activities is inversely related with GH in POTS. A higher supine diastolic BP is inversely associated with GH levels in POTS and healthy individuals.</p>}},
  author       = {{Johansson, Madeleine and Ricci, Fabrizio and Schulte, Janin and Persson, Margaretha and Melander, Olle and Sutton, Richard and Hamrefors, Viktor and Fedorowski, Artur}},
  issn         = {{2045-2322}},
  keywords     = {{Pots; Growth hormone}},
  language     = {{eng}},
  month        = {{04}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Circulating levels of growth hormone in postural orthostatic tachycardia syndrome}},
  url          = {{http://dx.doi.org/10.1038/s41598-021-87983-5}},
  doi          = {{10.1038/s41598-021-87983-5}},
  volume       = {{11}},
  year         = {{2021}},
}