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Boronate-containing polymers form affinity complexes with mucin and enable tight and reversible occlusion of mucosal lumen by poly (vinyl alcohol) gel

Ivanov, Alexander LU ; Nilsson, Lars LU ; Galaev, Igor LU and Mattiasson, Bo LU (2008) In International Journal of Pharmaceutics 358(1-2). p.36-43
Abstract
Copolymers of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with N,N-dimethylarcrylamide (DMAA) formed insoluble interpolymer complexes with mucin from porcine stomach at pH 9.0. The complex formation based on boronate-sugar interactions took place between the similarly charged macromolecules and resulted in coacervate particles formation, which depended both on pH and ionic strength of the solution. the coacervation rate displayed a maximum at the intermediate DMAA_NAAPBA copolymer: mucin weight ratio, that is a pattern typical of interpolymer complex formation.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Mucoadhesive, Drug delivery, Boronic acid, Controlled release, Smart material
in
International Journal of Pharmaceutics
volume
358
issue
1-2
pages
36 - 43
publisher
Elsevier
external identifiers
  • pmid:18394833
  • wos:000257577400005
  • scopus:44449157070
  • pmid:18394833
ISSN
1873-3476
DOI
10.1016/j.ijpharm.2008.02.017
language
English
LU publication?
yes
id
e23f2f82-03e4-4822-813f-42861af0b018 (old id 1165981)
date added to LUP
2016-04-01 11:53:25
date last changed
2025-10-14 11:54:59
@article{e23f2f82-03e4-4822-813f-42861af0b018,
  abstract     = {{Copolymers of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with N,N-dimethylarcrylamide (DMAA) formed insoluble interpolymer complexes with mucin from porcine stomach at pH 9.0. The complex formation based on boronate-sugar interactions took place between the similarly charged macromolecules and resulted in coacervate particles formation, which depended both on pH and ionic strength of the solution. the coacervation rate displayed a maximum at the intermediate DMAA_NAAPBA copolymer: mucin weight ratio, that is a pattern typical of interpolymer complex formation.}},
  author       = {{Ivanov, Alexander and Nilsson, Lars and Galaev, Igor and Mattiasson, Bo}},
  issn         = {{1873-3476}},
  keywords     = {{Mucoadhesive; Drug delivery; Boronic acid; Controlled release; Smart material}},
  language     = {{eng}},
  number       = {{1-2}},
  pages        = {{36--43}},
  publisher    = {{Elsevier}},
  series       = {{International Journal of Pharmaceutics}},
  title        = {{Boronate-containing polymers form affinity complexes with mucin and enable tight and reversible occlusion of mucosal lumen by poly (vinyl alcohol) gel}},
  url          = {{http://dx.doi.org/10.1016/j.ijpharm.2008.02.017}},
  doi          = {{10.1016/j.ijpharm.2008.02.017}},
  volume       = {{358}},
  year         = {{2008}},
}