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Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies

Agarwal, Pallavi; Schulz, Jan-Niklas; Blumbach, Katrin; Andréasson, Kristofer LU ; Heinegård, Dick LU ; Paulsson, Mats; Mauch, Cornelia; Eming, Sabine A.; Eckes, Beate and Krieg, Thomas (2013) In Matrix Biology 32(6). p.325-331
Abstract
Skin fibrosis is characterized by activated fibroblasts and an altered architecture of the extracellular matrix. Excessive deposition of extracellular matrix proteins and altered cytokine levels in the dermal collagen matrix are common to several pathological situations such as localized scleroderma and systemic sclerosis, keloids, dermatosclerosis associated with venous ulcers and the fibroproliferative tissue surrounding invasively growing tumors. Which factors contribute to altered organization of dermal collagen matrix in skin fibrosis is not well understood. We recently demonstrated that cartilage oligomeric matrix protein (COMP) functions as organizer of the dermal collagen I network in healthy human skin (Agarwal et al., 2012). Here... (More)
Skin fibrosis is characterized by activated fibroblasts and an altered architecture of the extracellular matrix. Excessive deposition of extracellular matrix proteins and altered cytokine levels in the dermal collagen matrix are common to several pathological situations such as localized scleroderma and systemic sclerosis, keloids, dermatosclerosis associated with venous ulcers and the fibroproliferative tissue surrounding invasively growing tumors. Which factors contribute to altered organization of dermal collagen matrix in skin fibrosis is not well understood. We recently demonstrated that cartilage oligomeric matrix protein (COMP) functions as organizer of the dermal collagen I network in healthy human skin (Agarwal et al., 2012). Here we show that COMP deposition is enhanced in the dermis in various fibrotic conditions. COMP levels were significantly increased in fibrotic lesions derived from patients with localized scleroderma, in wound tissue and exudates of patients with venous leg ulcers and in the fibrotic stroma of biopsies from patients with basal cell carcinoma. We postulate enhanced deposition of COMP as one of the common factors altering the supramolecular architecture of collagen matrix in fibrotic skin pathologies. Interestingly, COMP remained nearly undetectable in normally healing wounds where myofibroblasts transiently accumulate in the granulation tissue. We conclude that COMP expression is restricted to a fibroblast differentiation state not identical to myofibroblasts which is induced by TGF beta and biomechanical forces. (C) 2013 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
COMP, ECM organization, Collagen fibrils, Basal cell carcinoma, Chronic, wounds, Fibroplastic stroma response
in
Matrix Biology
volume
32
issue
6
pages
325 - 331
publisher
Elsevier
external identifiers
  • wos:000324455900005
  • scopus:84882626587
ISSN
1569-1802
DOI
10.1016/j.matbio.2013.02.010
language
English
LU publication?
yes
id
e273675e-01e0-418e-9572-d08e231fc379 (old id 4103234)
date added to LUP
2013-11-07 14:20:43
date last changed
2019-03-19 01:56:37
@article{e273675e-01e0-418e-9572-d08e231fc379,
  abstract     = {Skin fibrosis is characterized by activated fibroblasts and an altered architecture of the extracellular matrix. Excessive deposition of extracellular matrix proteins and altered cytokine levels in the dermal collagen matrix are common to several pathological situations such as localized scleroderma and systemic sclerosis, keloids, dermatosclerosis associated with venous ulcers and the fibroproliferative tissue surrounding invasively growing tumors. Which factors contribute to altered organization of dermal collagen matrix in skin fibrosis is not well understood. We recently demonstrated that cartilage oligomeric matrix protein (COMP) functions as organizer of the dermal collagen I network in healthy human skin (Agarwal et al., 2012). Here we show that COMP deposition is enhanced in the dermis in various fibrotic conditions. COMP levels were significantly increased in fibrotic lesions derived from patients with localized scleroderma, in wound tissue and exudates of patients with venous leg ulcers and in the fibrotic stroma of biopsies from patients with basal cell carcinoma. We postulate enhanced deposition of COMP as one of the common factors altering the supramolecular architecture of collagen matrix in fibrotic skin pathologies. Interestingly, COMP remained nearly undetectable in normally healing wounds where myofibroblasts transiently accumulate in the granulation tissue. We conclude that COMP expression is restricted to a fibroblast differentiation state not identical to myofibroblasts which is induced by TGF beta and biomechanical forces. (C) 2013 Elsevier B.V. All rights reserved.},
  author       = {Agarwal, Pallavi and Schulz, Jan-Niklas and Blumbach, Katrin and Andréasson, Kristofer and Heinegård, Dick and Paulsson, Mats and Mauch, Cornelia and Eming, Sabine A. and Eckes, Beate and Krieg, Thomas},
  issn         = {1569-1802},
  keyword      = {COMP,ECM organization,Collagen fibrils,Basal cell carcinoma,Chronic,wounds,Fibroplastic stroma response},
  language     = {eng},
  number       = {6},
  pages        = {325--331},
  publisher    = {Elsevier},
  series       = {Matrix Biology},
  title        = {Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies},
  url          = {http://dx.doi.org/10.1016/j.matbio.2013.02.010},
  volume       = {32},
  year         = {2013},
}