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Serum bone turnover markers were associated with bone mass in late prepuberty and early puberty

Rempe, Jakob LU orcid ; Rosengren, Björn E. LU ; Jehpsson, Lars LU ; Swärd, Per LU ; Dencker, Magnus LU and Karlsson, Magnus K. LU (2025) In Acta Paediatrica, International Journal of Paediatrics 114(5). p.944-953
Abstract

Aim: To analyse the association between bone turnover markers and bone mass in children and young adults. Methods: This descriptive study followed 132 children (68 boys/64 girls) from Malmö, Sweden, as controls in a school-based intervention study (2000–2017). Height, weight, Tanner stage and bone mass were measured annually from ages 8 to 15 years, with follow-ups at 19 and 23 years of age. Serum markers for bone formation (bone-specific alkaline phosphatase (bALP), N-terminal propeptide of collagen type 1 (PINP), osteocalcin) and resorption (C-terminal telopeptide crosslinks (CTX), tartrate-resistant acid phosphatase (TRAcP 5b)) were collected at ages 9.9 ± 0.6 (mean ± SD) (n = 78), 12.0 ± 0.6 (n = 64), 14.9 ± 0.8 (n = 52), 18.8 ± 0.3... (More)

Aim: To analyse the association between bone turnover markers and bone mass in children and young adults. Methods: This descriptive study followed 132 children (68 boys/64 girls) from Malmö, Sweden, as controls in a school-based intervention study (2000–2017). Height, weight, Tanner stage and bone mass were measured annually from ages 8 to 15 years, with follow-ups at 19 and 23 years of age. Serum markers for bone formation (bone-specific alkaline phosphatase (bALP), N-terminal propeptide of collagen type 1 (PINP), osteocalcin) and resorption (C-terminal telopeptide crosslinks (CTX), tartrate-resistant acid phosphatase (TRAcP 5b)) were collected at ages 9.9 ± 0.6 (mean ± SD) (n = 78), 12.0 ± 0.6 (n = 64), 14.9 ± 0.8 (n = 52), 18.8 ± 0.3 (n = 34) and 23.3 ± 0.6 years (n = 56). Results: Compared to girls, boys showed higher bone turnover markers at ages 15, 19 and 23 years (all p < 0.05). At 10 years of age (Tanner stage 1 and 2), bALP and TRAcP 5b correlated with current bone mass (adjusted for age and sex), while bALP, PINP, osteocalcin and CTX correlated with bone mass change over the next 2 years (adjusted for age, sex and interval) (all p < 0.05). Conclusion: Bone turnover markers in early Tanner stages predicted both current bone mass and subsequent bone mass changes.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bone mass, bone turnover markers, osteocalcin, pubertal development, Tanner
in
Acta Paediatrica, International Journal of Paediatrics
volume
114
issue
5
pages
944 - 953
publisher
Wiley-Blackwell
external identifiers
  • scopus:85209941338
  • pmid:39572456
ISSN
0803-5253
DOI
10.1111/apa.17510
language
English
LU publication?
yes
id
e30639de-33c1-443b-abcc-bd20da2827de
date added to LUP
2025-02-17 13:21:46
date last changed
2025-11-25 13:18:32
@article{e30639de-33c1-443b-abcc-bd20da2827de,
  abstract     = {{<p>Aim: To analyse the association between bone turnover markers and bone mass in children and young adults. Methods: This descriptive study followed 132 children (68 boys/64 girls) from Malmö, Sweden, as controls in a school-based intervention study (2000–2017). Height, weight, Tanner stage and bone mass were measured annually from ages 8 to 15 years, with follow-ups at 19 and 23 years of age. Serum markers for bone formation (bone-specific alkaline phosphatase (bALP), N-terminal propeptide of collagen type 1 (PINP), osteocalcin) and resorption (C-terminal telopeptide crosslinks (CTX), tartrate-resistant acid phosphatase (TRAcP 5b)) were collected at ages 9.9 ± 0.6 (mean ± SD) (n = 78), 12.0 ± 0.6 (n = 64), 14.9 ± 0.8 (n = 52), 18.8 ± 0.3 (n = 34) and 23.3 ± 0.6 years (n = 56). Results: Compared to girls, boys showed higher bone turnover markers at ages 15, 19 and 23 years (all p &lt; 0.05). At 10 years of age (Tanner stage 1 and 2), bALP and TRAcP 5b correlated with current bone mass (adjusted for age and sex), while bALP, PINP, osteocalcin and CTX correlated with bone mass change over the next 2 years (adjusted for age, sex and interval) (all p &lt; 0.05). Conclusion: Bone turnover markers in early Tanner stages predicted both current bone mass and subsequent bone mass changes.</p>}},
  author       = {{Rempe, Jakob and Rosengren, Björn E. and Jehpsson, Lars and Swärd, Per and Dencker, Magnus and Karlsson, Magnus K.}},
  issn         = {{0803-5253}},
  keywords     = {{bone mass; bone turnover markers; osteocalcin; pubertal development; Tanner}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{944--953}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Paediatrica, International Journal of Paediatrics}},
  title        = {{Serum bone turnover markers were associated with bone mass in late prepuberty and early puberty}},
  url          = {{http://dx.doi.org/10.1111/apa.17510}},
  doi          = {{10.1111/apa.17510}},
  volume       = {{114}},
  year         = {{2025}},
}