Interactions between cultured bovine arterial endothelial and smooth muscle cells: studies on uptake and degradation of low density lipoproteins by smooth muscle cells
Xu, Cang-Bao LU ; Stavenow, L ; Liao, W ; Erlinge, David LU
and Edvinsson, Lars
LU
(1993)
In Pharmacology and Toxicology
73(5).
p.269-273
- Abstract
- This study was designed to investigate the effects of substances released from non-injured and injured bovine arterial endothelial cells on 125I-low density lipoprotein uptake and degradation by smooth muscle cells in culture. It was demonstrated that endothelial cell-released non-dialysable (molecular weight cut off 12-14000) substances significantly stimulated 125I-low density lipoprotein uptake and degradation by smooth muscle cells. Endothelial cell-released dialysable substances and endothelin-1 did not cause this stimulation. The increase in 125I-low density lipoprotein uptake and degradation by smooth muscle cells could be dissociated from cell proliferation. However, in endothelial cell-smooth muscle cell co-culture 125I-low... (More)
- This study was designed to investigate the effects of substances released from non-injured and injured bovine arterial endothelial cells on 125I-low density lipoprotein uptake and degradation by smooth muscle cells in culture. It was demonstrated that endothelial cell-released non-dialysable (molecular weight cut off 12-14000) substances significantly stimulated 125I-low density lipoprotein uptake and degradation by smooth muscle cells. Endothelial cell-released dialysable substances and endothelin-1 did not cause this stimulation. The increase in 125I-low density lipoprotein uptake and degradation by smooth muscle cells could be dissociated from cell proliferation. However, in endothelial cell-smooth muscle cell co-culture 125I-low density lipoprotein uptake and degradation by smooth muscle cells were not stimulated. Injury to endothelial cells by lipid-soluble smoke particles or ultraviolet light, which reduced total cellular protein by 15-25%, enhanced the endothelial cell release of the substances stimulating 125I-low density lipoprotein uptake. The results are discussed in relation to atherogenesis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107182
- author
- Xu, Cang-Bao
LU
; Stavenow, L
; Liao, W
; Erlinge, David
LU
and Edvinsson, Lars
LU
- organization
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pharmacology and Toxicology
- volume
- 73
- issue
- 5
- pages
- 269 - 273
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:8115309
- scopus:0027143629
- ISSN
- 1600-0773
- language
- English
- LU publication?
- yes
- id
- e328883f-12c1-4d3a-a8e7-8700ca87f7ac (old id 1107182)
- date added to LUP
- 2016-04-01 12:01:30
- date last changed
- 2024-01-08 05:20:25
@article{e328883f-12c1-4d3a-a8e7-8700ca87f7ac,
abstract = {{This study was designed to investigate the effects of substances released from non-injured and injured bovine arterial endothelial cells on 125I-low density lipoprotein uptake and degradation by smooth muscle cells in culture. It was demonstrated that endothelial cell-released non-dialysable (molecular weight cut off 12-14000) substances significantly stimulated 125I-low density lipoprotein uptake and degradation by smooth muscle cells. Endothelial cell-released dialysable substances and endothelin-1 did not cause this stimulation. The increase in 125I-low density lipoprotein uptake and degradation by smooth muscle cells could be dissociated from cell proliferation. However, in endothelial cell-smooth muscle cell co-culture 125I-low density lipoprotein uptake and degradation by smooth muscle cells were not stimulated. Injury to endothelial cells by lipid-soluble smoke particles or ultraviolet light, which reduced total cellular protein by 15-25%, enhanced the endothelial cell release of the substances stimulating 125I-low density lipoprotein uptake. The results are discussed in relation to atherogenesis.}},
author = {{Xu, Cang-Bao and Stavenow, L and Liao, W and Erlinge, David and Edvinsson, Lars}},
issn = {{1600-0773}},
language = {{eng}},
number = {{5}},
pages = {{269--273}},
publisher = {{Wiley-Blackwell}},
series = {{Pharmacology and Toxicology}},
title = {{Interactions between cultured bovine arterial endothelial and smooth muscle cells: studies on uptake and degradation of low density lipoproteins by smooth muscle cells}},
volume = {{73}},
year = {{1993}},
}