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A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study

Papadimitriou, Nikos ; Muller, David ; van den Brandt, Piet A. ; Geybels, Milan ; Patel, Chirag J. ; Gunter, Marc J. ; Lopez, David S. ; Key, Timothy J. ; Perez-Cornago, Aurora and Ferrari, Pietro , et al. (2020) In European Journal of Nutrition 59(7). p.2929-2937
Abstract

Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. 

Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false... (More)

Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. 

Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR < 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). 

Results: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. 

Conclusions: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cohort study, Diet, Epidemiology, Nutrition, Prostate cancer
in
European Journal of Nutrition
volume
59
issue
7
pages
9 pages
publisher
Springer
external identifiers
  • pmid:31705265
  • scopus:85074989410
ISSN
1436-6207
DOI
10.1007/s00394-019-02132-z
language
English
LU publication?
yes
id
e470e7ab-e200-4f1c-b65a-d327d88817e2
date added to LUP
2019-12-06 09:06:04
date last changed
2024-09-04 13:09:31
@article{e470e7ab-e200-4f1c-b65a-d327d88817e2,
  abstract     = {{<p>Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. </p><p>Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR &lt; 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). </p><p>Results: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. </p><p>Conclusions: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.</p>}},
  author       = {{Papadimitriou, Nikos and Muller, David and van den Brandt, Piet A. and Geybels, Milan and Patel, Chirag J. and Gunter, Marc J. and Lopez, David S. and Key, Timothy J. and Perez-Cornago, Aurora and Ferrari, Pietro and Vineis, Paolo and Weiderpass, Elisabete and Boeing, Heiner and Agudo, Antonio and Sánchez, María José and Overvad, Kim and Kühn, Tilman and Fortner, Renee T. and Palli, Domenico and Drake, Isabel and Bjartell, Anders and Santiuste, Carmen and Bueno-de-Mesquita, Bas H. and Krogh, Vittorio and Tjønneland, Anne and Lauritzen, Dorthe Furstrand and Gurrea, Aurelio Barricarte and Quirós, José Ramón and Stattin, Pär and Trichopoulou, Antonia and Martimianaki, Georgia and Karakatsani, Anna and Thysell, Elin and Johansson, Ingegerd and Ricceri, Fulvio and Tumino, Rosario and Larrañaga, Nerea and Khaw, Kay Tee and Riboli, Elio and Tzoulaki, Ioanna and Tsilidis, Konstantinos K.}},
  issn         = {{1436-6207}},
  keywords     = {{Cohort study; Diet; Epidemiology; Nutrition; Prostate cancer}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{2929--2937}},
  publisher    = {{Springer}},
  series       = {{European Journal of Nutrition}},
  title        = {{A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study}},
  url          = {{http://dx.doi.org/10.1007/s00394-019-02132-z}},
  doi          = {{10.1007/s00394-019-02132-z}},
  volume       = {{59}},
  year         = {{2020}},
}