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Population-Attributable Fractions of Personal Comorbidities for Liver, Gallbladder, and Bile Duct Cancers

Hemminki, Kari LU ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Försti, Asta LU ; Liska, Vaclav ; Hemminki, Akseli and Li, Xinjun LU (2023) In Cancers 15(12).
Abstract

Background: We aim to estimate population-attributable fractions (PAF) for 13 comorbidities potentially predisposing to hepatobiliary cancer of hepatocellular carcinoma (HCC), gallbladder cancer (GBC), cancers of the intrahepatic and extrahepatic bile ducts (ICC and ECC), and ampullary cancer. Methods: Patients were identified from the Swedish Inpatient Register from 1987 to 2018 and cancers from the Swedish Cancer Registry from 1997 through 2018. PAFs were calculated for each comorbidity-associated cancer using a cohort study design. Results: For male HCC, the major individual comorbidities (PAF > 10) were diabetes, alcohol-related liver disease, and hepatitis C virus infection. For female HCC, diabetes and autoimmune diseases were... (More)

Background: We aim to estimate population-attributable fractions (PAF) for 13 comorbidities potentially predisposing to hepatobiliary cancer of hepatocellular carcinoma (HCC), gallbladder cancer (GBC), cancers of the intrahepatic and extrahepatic bile ducts (ICC and ECC), and ampullary cancer. Methods: Patients were identified from the Swedish Inpatient Register from 1987 to 2018 and cancers from the Swedish Cancer Registry from 1997 through 2018. PAFs were calculated for each comorbidity-associated cancer using a cohort study design. Results: For male HCC, the major individual comorbidities (PAF > 10) were diabetes, alcohol-related liver disease, and hepatitis C virus infection. For female HCC, diabetes and autoimmune diseases were important contributors. For female GBC, gallstone disease was an overwhelming contributor, with a PAF of 30.57%, which was also important for men. The overall PAF for male ICC was almost two times higher than the female one. For ECC and ampullary cancer, infection of bile ducts was associated with the highest PAF. Conclusions: The 13 comorbidities accounted for 50% or more of the potential etiological pathways of each hepatobiliary cancer except female ICC. The underlying convergent mechanism for these cancers may be chronic inflammation lasting for decades and thus offering possibilities for intervention and disease monitoring.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alcohol, bile duct infection, comorbidity, hepatocellular carcinoma, risk factor, viral infection
in
Cancers
volume
15
issue
12
article number
3092
publisher
MDPI AG
external identifiers
  • pmid:37370702
  • scopus:85164028792
ISSN
2072-6694
DOI
10.3390/cancers15123092
language
English
LU publication?
yes
id
e47fc929-fb2c-4c89-9d4e-50e7f3bedd5d
date added to LUP
2023-09-15 14:20:03
date last changed
2024-04-19 00:58:06
@article{e47fc929-fb2c-4c89-9d4e-50e7f3bedd5d,
  abstract     = {{<p>Background: We aim to estimate population-attributable fractions (PAF) for 13 comorbidities potentially predisposing to hepatobiliary cancer of hepatocellular carcinoma (HCC), gallbladder cancer (GBC), cancers of the intrahepatic and extrahepatic bile ducts (ICC and ECC), and ampullary cancer. Methods: Patients were identified from the Swedish Inpatient Register from 1987 to 2018 and cancers from the Swedish Cancer Registry from 1997 through 2018. PAFs were calculated for each comorbidity-associated cancer using a cohort study design. Results: For male HCC, the major individual comorbidities (PAF &gt; 10) were diabetes, alcohol-related liver disease, and hepatitis C virus infection. For female HCC, diabetes and autoimmune diseases were important contributors. For female GBC, gallstone disease was an overwhelming contributor, with a PAF of 30.57%, which was also important for men. The overall PAF for male ICC was almost two times higher than the female one. For ECC and ampullary cancer, infection of bile ducts was associated with the highest PAF. Conclusions: The 13 comorbidities accounted for 50% or more of the potential etiological pathways of each hepatobiliary cancer except female ICC. The underlying convergent mechanism for these cancers may be chronic inflammation lasting for decades and thus offering possibilities for intervention and disease monitoring.</p>}},
  author       = {{Hemminki, Kari and Sundquist, Kristina and Sundquist, Jan and Försti, Asta and Liska, Vaclav and Hemminki, Akseli and Li, Xinjun}},
  issn         = {{2072-6694}},
  keywords     = {{alcohol; bile duct infection; comorbidity; hepatocellular carcinoma; risk factor; viral infection}},
  language     = {{eng}},
  number       = {{12}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Population-Attributable Fractions of Personal Comorbidities for Liver, Gallbladder, and Bile Duct Cancers}},
  url          = {{http://dx.doi.org/10.3390/cancers15123092}},
  doi          = {{10.3390/cancers15123092}},
  volume       = {{15}},
  year         = {{2023}},
}