Signals and regulators that govern Streptomyces development
(2012) In FEMS Microbiology Reviews 36(1). p.206-231- Abstract
- Streptomyces coelicolor is the genetically best characterized species of a populous genus belonging to the gram-positive Actinobacteria. Streptomycetes are filamentous soil organisms, well known for the production of a plethora of biologically active secondary metabolic compounds. The Streptomyces developmental life cycle is uniquely complex and involves coordinated multicellular development with both physiological and morphological differentiation of several cell types, culminating in the production of secondary metabolites and dispersal of mature spores. This review presents a current appreciation of the signaling mechanisms used to orchestrate the decision to undergo morphological differentiation, and the regulators and regulatory... (More)
- Streptomyces coelicolor is the genetically best characterized species of a populous genus belonging to the gram-positive Actinobacteria. Streptomycetes are filamentous soil organisms, well known for the production of a plethora of biologically active secondary metabolic compounds. The Streptomyces developmental life cycle is uniquely complex and involves coordinated multicellular development with both physiological and morphological differentiation of several cell types, culminating in the production of secondary metabolites and dispersal of mature spores. This review presents a current appreciation of the signaling mechanisms used to orchestrate the decision to undergo morphological differentiation, and the regulators and regulatory networks that direct the intriguing development of multigenomic hyphae first to form specialized aerial hyphae and then to convert them into chains of dormant spores. This current view of S. coelicolor development is destined for rapid evolution as data from -omics studies shed light on gene regulatory networks, new genetic screens identify hitherto unknown players, and the resolution of our insights into the underlying cell biological processes steadily improve. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2425525
- author
- McCormick, Joseph R. and Flärdh, Klas LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- differentiation, development, sporulation, cell division, chromosome, segregation
- in
- FEMS Microbiology Reviews
- volume
- 36
- issue
- 1
- pages
- 206 - 231
- publisher
- Oxford University Press
- external identifiers
-
- wos:000298061900011
- scopus:83355162664
- pmid:22092088
- ISSN
- 1574-6976
- DOI
- 10.1111/j.1574-6976.2011.00317.x
- language
- English
- LU publication?
- yes
- id
- e4f67488-b092-42d3-ba61-0389ed5610aa (old id 2425525)
- date added to LUP
- 2016-04-01 10:40:51
- date last changed
- 2024-05-06 16:57:37
@article{e4f67488-b092-42d3-ba61-0389ed5610aa,
abstract = {{Streptomyces coelicolor is the genetically best characterized species of a populous genus belonging to the gram-positive Actinobacteria. Streptomycetes are filamentous soil organisms, well known for the production of a plethora of biologically active secondary metabolic compounds. The Streptomyces developmental life cycle is uniquely complex and involves coordinated multicellular development with both physiological and morphological differentiation of several cell types, culminating in the production of secondary metabolites and dispersal of mature spores. This review presents a current appreciation of the signaling mechanisms used to orchestrate the decision to undergo morphological differentiation, and the regulators and regulatory networks that direct the intriguing development of multigenomic hyphae first to form specialized aerial hyphae and then to convert them into chains of dormant spores. This current view of S. coelicolor development is destined for rapid evolution as data from -omics studies shed light on gene regulatory networks, new genetic screens identify hitherto unknown players, and the resolution of our insights into the underlying cell biological processes steadily improve.}},
author = {{McCormick, Joseph R. and Flärdh, Klas}},
issn = {{1574-6976}},
keywords = {{differentiation; development; sporulation; cell division; chromosome; segregation}},
language = {{eng}},
number = {{1}},
pages = {{206--231}},
publisher = {{Oxford University Press}},
series = {{FEMS Microbiology Reviews}},
title = {{Signals and regulators that govern Streptomyces development}},
url = {{http://dx.doi.org/10.1111/j.1574-6976.2011.00317.x}},
doi = {{10.1111/j.1574-6976.2011.00317.x}},
volume = {{36}},
year = {{2012}},
}