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A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Gateva, Vesela ; Sandling, Johanna K. ; Hom, Geoff ; Taylor, Kimberly E. ; Chung, Sharon A. ; Sun, Xin ; Ortmann, Ward ; Kosoy, Roman ; Ferreira, Ricardo C. and Nordmark, Gunnel , et al. (2009) In Nature Genetics 41(11). p.93-1228
Abstract
Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329 controls. This replication effort identified five new SLE susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19). We identified 21 additional candidate loci with P <= 1 x 10(-5). A candidate screen of alleles previously associated with other autoimmune diseases suggested five loci (P < 1 x... (More)
Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329 controls. This replication effort identified five new SLE susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19). We identified 21 additional candidate loci with P <= 1 x 10(-5). A candidate screen of alleles previously associated with other autoimmune diseases suggested five loci (P < 1 x 10(-3)) that may contribute to SLE: IFIH1, CFB, CLEC16A, IL12B and SH2B3. These results expand the number of confirmed and candidate SLE susceptibility loci and implicate several key immunologic pathways in SLE pathogenesis. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Genetics
volume
41
issue
11
pages
93 - 1228
publisher
Nature Publishing Group
external identifiers
  • wos:000271247600016
  • scopus:70350650472
  • pmid:19838195
ISSN
1546-1718
DOI
10.1038/ng.468
language
English
LU publication?
yes
id
e4f7e135-9beb-4ba3-bd8f-5aa4c4f8d177 (old id 1504952)
date added to LUP
2016-04-01 14:04:27
date last changed
2022-04-06 08:40:27
@article{e4f7e135-9beb-4ba3-bd8f-5aa4c4f8d177,
  abstract     = {{Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P &lt; 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329 controls. This replication effort identified five new SLE susceptibility loci (P &lt; 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19). We identified 21 additional candidate loci with P &lt;= 1 x 10(-5). A candidate screen of alleles previously associated with other autoimmune diseases suggested five loci (P &lt; 1 x 10(-3)) that may contribute to SLE: IFIH1, CFB, CLEC16A, IL12B and SH2B3. These results expand the number of confirmed and candidate SLE susceptibility loci and implicate several key immunologic pathways in SLE pathogenesis.}},
  author       = {{Gateva, Vesela and Sandling, Johanna K. and Hom, Geoff and Taylor, Kimberly E. and Chung, Sharon A. and Sun, Xin and Ortmann, Ward and Kosoy, Roman and Ferreira, Ricardo C. and Nordmark, Gunnel and Gunnarsson, Iva and Svenungsson, Elisabet and Padyukov, Leonid and Sturfelt, Gunnar and Jönsen, Andreas and Bengtsson, Anders and Rantapaa-Dahlqvist, Solbritt and Baechler, Emily C. and Brown, Elizabeth E. and Alarcon, Graciela S. and Edberg, Jeffrey C. and Ramsey-Goldman, Rosalind and McGwin, Gerald, Jr. and Reveille, John D. and Vila, Luis M. and Kimberly, Robert P. and Manzi, Susan and Petri, Michelle A. and Lee, Annette and Gregersen, Peter K. and Seldin, Michael F. and Ronnblom, Lars and Criswell, Lindsey A. and Syvanen, Ann-Christine and Behrens, Timothy W. and Graham, Robert R.}},
  issn         = {{1546-1718}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{93--1228}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Genetics}},
  title        = {{A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus}},
  url          = {{http://dx.doi.org/10.1038/ng.468}},
  doi          = {{10.1038/ng.468}},
  volume       = {{41}},
  year         = {{2009}},
}