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SiPP (Stroke in Pregnancy and Postpartum) : A prospective, observational, international, multicentre study on pathophysiological mechanisms, clinical profile, management and outcome of cerebrovascular diseases in pregnant and postpartum women

Lorenzano, Svetlana ; Kremer, Christine LU ; Pavlovic, Aleksandra ; Jovanovic, Dejana R. ; Sandset, Else Charlotte ; Christensen, Hanne ; Bushnell, Cheryl ; Arsovska, Anita ; Sprigg, Nikola and Roffe, Christine , et al. (2020) In European Stroke Journal 5(2). p.193-203
Abstract

Rationale: Cerebrovascular diseases associated with pregnancy and postpartum period are uncommon; however, they can have an important impact on health of both women and foetus or newborn. Aims: To evaluate the frequency, characteristics and management of cerebrovascular events in pregnant/postpartum women, to clarify pathophysiological mechanisms underlying the occurrence of these events including biomolecular aspects, and to assess the short- and long-term cerebrovascular and global cardiovascular outcome of these patients, their predictors and infant outcome. Methods and design: This is an observational, prospective, multicentre, international case–control study. The study will include patients with cerebrovascular events during... (More)

Rationale: Cerebrovascular diseases associated with pregnancy and postpartum period are uncommon; however, they can have an important impact on health of both women and foetus or newborn. Aims: To evaluate the frequency, characteristics and management of cerebrovascular events in pregnant/postpartum women, to clarify pathophysiological mechanisms underlying the occurrence of these events including biomolecular aspects, and to assess the short- and long-term cerebrovascular and global cardiovascular outcome of these patients, their predictors and infant outcome. Methods and design: This is an observational, prospective, multicentre, international case–control study. The study will include patients with cerebrovascular events during pregnancy and/or within six months after delivery. For each included case, two controls will be prospectively recruited: one pregnant or puerperal subject without any history of cerebrovascular event and one non-pregnant or non-puerperal subject with a recent cerebrovascular event. All controls will be matched by age, ethnicity and type of cerebrovascular event with their assigned cases. The pregnant controls will be matched also by pregnancy weeks/trimester. Follow-up will last 24 months for the mother and 12 months for the infant. Summary: To better understand causes and outcomes of uncommon conditions like pregnancy/postpartum-related cerebrovascular events, the development of multisite, multidisciplinary registry-based studies, such as the Stroke in Pregnancy and Postpartum study, is needed in order to collect an adequate number of patients, draw reliable conclusions and give definite recommendations on their management.

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author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebrovascular disease, outcome, postpartum, pregnancy, puerperium, Stroke
in
European Stroke Journal
volume
5
issue
2
pages
11 pages
publisher
SAGE Publications
external identifiers
  • scopus:85077375173
  • pmid:32637653
ISSN
2396-9873
DOI
10.1177/2396987319893512
language
English
LU publication?
yes
id
e4fd9f5e-bbfe-48ea-997d-11f7260b408f
date added to LUP
2020-01-17 13:36:36
date last changed
2021-05-11 05:32:02
@article{e4fd9f5e-bbfe-48ea-997d-11f7260b408f,
  abstract     = {<p>Rationale: Cerebrovascular diseases associated with pregnancy and postpartum period are uncommon; however, they can have an important impact on health of both women and foetus or newborn. Aims: To evaluate the frequency, characteristics and management of cerebrovascular events in pregnant/postpartum women, to clarify pathophysiological mechanisms underlying the occurrence of these events including biomolecular aspects, and to assess the short- and long-term cerebrovascular and global cardiovascular outcome of these patients, their predictors and infant outcome. Methods and design: This is an observational, prospective, multicentre, international case–control study. The study will include patients with cerebrovascular events during pregnancy and/or within six months after delivery. For each included case, two controls will be prospectively recruited: one pregnant or puerperal subject without any history of cerebrovascular event and one non-pregnant or non-puerperal subject with a recent cerebrovascular event. All controls will be matched by age, ethnicity and type of cerebrovascular event with their assigned cases. The pregnant controls will be matched also by pregnancy weeks/trimester. Follow-up will last 24 months for the mother and 12 months for the infant. Summary: To better understand causes and outcomes of uncommon conditions like pregnancy/postpartum-related cerebrovascular events, the development of multisite, multidisciplinary registry-based studies, such as the Stroke in Pregnancy and Postpartum study, is needed in order to collect an adequate number of patients, draw reliable conclusions and give definite recommendations on their management.</p>},
  author       = {Lorenzano, Svetlana and Kremer, Christine and Pavlovic, Aleksandra and Jovanovic, Dejana R. and Sandset, Else Charlotte and Christensen, Hanne and Bushnell, Cheryl and Arsovska, Anita and Sprigg, Nikola and Roffe, Christine and Ijäs, Petra and Gdovinova, Zuzana and Alexandrov, Anne and Zedde, Marialuisa and Tassi, Rossana and Acciaresi, Monica and Lantz, Maria and Sunnerhagen, Katharina and Zarkov, Marija and Rantanen, Kirsi and Perren, Fabienne and Iversen, Helle K. and Kruuse, Christina and Slowik, Agnieszka and Palazzo, Paola and Korv, Janika and Fromm, Annette and Lovrencic-Huzjan, Arijana and Korompoki, Eleni and Fonseca, Ana Catarina and Gall, Seana L. and Brunner, Freimuth and Caso, Valeria and Sacco, Simona},
  issn         = {2396-9873},
  language     = {eng},
  month        = {06},
  number       = {2},
  pages        = {193--203},
  publisher    = {SAGE Publications},
  series       = {European Stroke Journal},
  title        = {SiPP (Stroke in Pregnancy and Postpartum) : A prospective, observational, international, multicentre study on pathophysiological mechanisms, clinical profile, management and outcome of cerebrovascular diseases in pregnant and postpartum women},
  url          = {http://dx.doi.org/10.1177/2396987319893512},
  doi          = {10.1177/2396987319893512},
  volume       = {5},
  year         = {2020},
}