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Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

Wardlaw, Joanna M.; Smith, Eric E.; Biessels, Geert J.; Cordonnier, Charlotte; Fazekas, Franz; Frayne, Richard; Lindley, Richard I.; O'Brien, John T.; Barkhof, Frederik and Benavente, Oscar R., et al. (2013) In Lancet Neurology 12(8). p.822-838
Abstract
Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. SVD can present as a stroke or cognitive decline, or can have few or no symptoms. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive deficits, physical disabilities, and other symptoms of neurodegeneration. Terminology and definitions for imaging the features of SVD vary widely, which is also true for protocols for image acquisition and image analysis. This lack of consistency hampers progress in identifying the contribution of SVD to the pathophysiology and clinical... (More)
Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. SVD can present as a stroke or cognitive decline, or can have few or no symptoms. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive deficits, physical disabilities, and other symptoms of neurodegeneration. Terminology and definitions for imaging the features of SVD vary widely, which is also true for protocols for image acquisition and image analysis. This lack of consistency hampers progress in identifying the contribution of SVD to the pathophysiology and clinical features of common neurodegenerative diseases. We are an international working group from the Centres of Excellence in Neurodegeneration. We completed a structured process to develop definitions and imaging standards for markers and consequences of SVD. We aimed to achieve the following: first, to provide a common advisory about terms and definitions for features visible on MRI; second, to suggest minimum standards for image acquisition and analysis; third, to agree on standards for scientific reporting of changes related to SVD on neuroimaging; and fourth, to review emerging imaging methods for detection and quantification of preclinical manifestations of SVD. Our findings and recommendations apply to research studies, and can be used in the clinical setting to standardise image interpretation, acquisition, and reporting. This Position Paper summarises the main outcomes of this international effort to provide the STandards for Reporting Vascular changes on nEuroimaging (STRIVE). (Less)
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@article{e55dc020-bc87-4837-87c4-8bf7ea4d1c57,
  abstract     = {Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. SVD can present as a stroke or cognitive decline, or can have few or no symptoms. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive deficits, physical disabilities, and other symptoms of neurodegeneration. Terminology and definitions for imaging the features of SVD vary widely, which is also true for protocols for image acquisition and image analysis. This lack of consistency hampers progress in identifying the contribution of SVD to the pathophysiology and clinical features of common neurodegenerative diseases. We are an international working group from the Centres of Excellence in Neurodegeneration. We completed a structured process to develop definitions and imaging standards for markers and consequences of SVD. We aimed to achieve the following: first, to provide a common advisory about terms and definitions for features visible on MRI; second, to suggest minimum standards for image acquisition and analysis; third, to agree on standards for scientific reporting of changes related to SVD on neuroimaging; and fourth, to review emerging imaging methods for detection and quantification of preclinical manifestations of SVD. Our findings and recommendations apply to research studies, and can be used in the clinical setting to standardise image interpretation, acquisition, and reporting. This Position Paper summarises the main outcomes of this international effort to provide the STandards for Reporting Vascular changes on nEuroimaging (STRIVE).},
  author       = {Wardlaw, Joanna M. and Smith, Eric E. and Biessels, Geert J. and Cordonnier, Charlotte and Fazekas, Franz and Frayne, Richard and Lindley, Richard I. and O'Brien, John T. and Barkhof, Frederik and Benavente, Oscar R. and Black, Sandra E. and Brayne, Carol and Breteler, Monique and Chabriat, Hugues and DeCarli, Charles and de Leeuw, Frank-Erik and Doubal, Fergus and Duering, Marco and Fox, Nick C. and Greenberg, Steven and Hachinski, Vladimir and Kilimann, Ingo and Mok, Vincent and van Oostenbrugge, Robert and Pantoni, Leonardo and Speck, Oliver and Stephan, Blossom C. M. and Teipel, Stefan and Viswanathan, Anand and Werring, David and Chen, Christopher and Smith, Colin and van Buchem, Mark and Norrving, Bo and Gorelick, Philip B. and Dichgans, Martin},
  issn         = {1474-4465},
  language     = {eng},
  number       = {8},
  pages        = {822--838},
  publisher    = {Lancet Ltd},
  series       = {Lancet Neurology},
  title        = {Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration},
  url          = {http://dx.doi.org/10.1016/S1474-4422(13)70124-8},
  volume       = {12},
  year         = {2013},
}