Prenatal phthalate exposure and early childhood wheeze in the SELMA study
(2022) In Journal of Exposure Science and Environmental Epidemiology 32(2). p.303-311- Abstract
Background: Prenatal maternal phthalate exposure has been associated with wheeze and asthma in children, but results are inconclusive. Previous studies typically assessed exposure in late pregnancy, included only a small number of old phthalates, and assessed outcomes in children aged 5 years or older. Objective: We explored associations between 1st trimester prenatal maternal exposure to a wider range of phthalates and wheeze in early childhood. Methods: First trimester concentrations of 14 metabolites from 8 phthalates and one alternative plasticizer were quantified in first-morning void urine from 1148 mothers in the Swedish SELMA study. Associations between log-transformed metabolite concentrations and parental reported ever wheeze... (More)
Background: Prenatal maternal phthalate exposure has been associated with wheeze and asthma in children, but results are inconclusive. Previous studies typically assessed exposure in late pregnancy, included only a small number of old phthalates, and assessed outcomes in children aged 5 years or older. Objective: We explored associations between 1st trimester prenatal maternal exposure to a wider range of phthalates and wheeze in early childhood. Methods: First trimester concentrations of 14 metabolites from 8 phthalates and one alternative plasticizer were quantified in first-morning void urine from 1148 mothers in the Swedish SELMA study. Associations between log-transformed metabolite concentrations and parental reported ever wheeze among 24-month-old children were investigated with logistic regression models adjusted for parental asthma/rhinitis, sex of child, maternal education, smoking, and creatinine. Results: Metabolites of replacement phthalates di-iso-decyl phthalate (DiDP) and di-2-propylheptyl phthalate (DPHP) were associated with increased risk for wheeze (aOR 1.47, 95% CI 1.08-2.01 and aOR 1.49, 95% CI 1.04–2.15, respectively). The associations with DiDP and DPHP were stronger among children whose parents did not have asthma or rhinitis. In this group, wheeze was also associated with metabolites of butyl-benzyl phthalate (BBzP) and di-iso-nonyl phthalate (DiNP). Significance: Maternal phthalate exposure during early pregnancy may be a risk factor for wheeze in early childhood, especially among children whose parents do not have asthma or rhinitis symptoms.
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- author
- Preece, Anna Sofia ; Knutz, Malin ; Lindh, Christian H. LU ; Bornehag, Carl Gustaf LU and Shu, Huan
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Children’s health, Endocrine disruption, Plasticizer, Pregnancy, Respiratory
- in
- Journal of Exposure Science and Environmental Epidemiology
- volume
- 32
- issue
- 2
- pages
- 303 - 311
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85114619396
- pmid:34475495
- ISSN
- 1559-0631
- DOI
- 10.1038/s41370-021-00382-w
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
- id
- e5a8d143-2161-4a1d-bc9a-8927589e3f26
- date added to LUP
- 2021-10-18 15:41:58
- date last changed
- 2024-09-22 03:18:00
@article{e5a8d143-2161-4a1d-bc9a-8927589e3f26, abstract = {{<p>Background: Prenatal maternal phthalate exposure has been associated with wheeze and asthma in children, but results are inconclusive. Previous studies typically assessed exposure in late pregnancy, included only a small number of old phthalates, and assessed outcomes in children aged 5 years or older. Objective: We explored associations between 1st trimester prenatal maternal exposure to a wider range of phthalates and wheeze in early childhood. Methods: First trimester concentrations of 14 metabolites from 8 phthalates and one alternative plasticizer were quantified in first-morning void urine from 1148 mothers in the Swedish SELMA study. Associations between log-transformed metabolite concentrations and parental reported ever wheeze among 24-month-old children were investigated with logistic regression models adjusted for parental asthma/rhinitis, sex of child, maternal education, smoking, and creatinine. Results: Metabolites of replacement phthalates di-iso-decyl phthalate (DiDP) and di-2-propylheptyl phthalate (DPHP) were associated with increased risk for wheeze (aOR 1.47, 95% CI 1.08-2.01 and aOR 1.49, 95% CI 1.04–2.15, respectively). The associations with DiDP and DPHP were stronger among children whose parents did not have asthma or rhinitis. In this group, wheeze was also associated with metabolites of butyl-benzyl phthalate (BBzP) and di-iso-nonyl phthalate (DiNP). Significance: Maternal phthalate exposure during early pregnancy may be a risk factor for wheeze in early childhood, especially among children whose parents do not have asthma or rhinitis symptoms.</p>}}, author = {{Preece, Anna Sofia and Knutz, Malin and Lindh, Christian H. and Bornehag, Carl Gustaf and Shu, Huan}}, issn = {{1559-0631}}, keywords = {{Children’s health; Endocrine disruption; Plasticizer; Pregnancy; Respiratory}}, language = {{eng}}, number = {{2}}, pages = {{303--311}}, publisher = {{Nature Publishing Group}}, series = {{Journal of Exposure Science and Environmental Epidemiology}}, title = {{Prenatal phthalate exposure and early childhood wheeze in the SELMA study}}, url = {{http://dx.doi.org/10.1038/s41370-021-00382-w}}, doi = {{10.1038/s41370-021-00382-w}}, volume = {{32}}, year = {{2022}}, }