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Effect of food intake on 92 neurological biomarkers in plasma

Dencker, Magnus LU ; Björgell, Ola LU and Hlebowicz, Joanna LU (2017) In Brain and Behavior
Abstract

Objective: This study evaluates the effect of food intake on 92 neurological biomarkers in plasma. Moreover, it investigated if any of the biomarkers were correlated with body mass index. Materials and Methods: Twenty-two healthy subjects (11 male and 11 female aged 25.9 ± 4.2 years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120 min afterward with the Proseek Multiplex Neurology I kit. Results: The levels for 13 biomarkers decreased significantly (p < .001) 30 min after food intake. The levels for four biomarkers remained significantly decreased (p < .001) 120 min after food intake. One biomarker increased significantly (p < .001) 30 min after food intake. The changes... (More)

Objective: This study evaluates the effect of food intake on 92 neurological biomarkers in plasma. Moreover, it investigated if any of the biomarkers were correlated with body mass index. Materials and Methods: Twenty-two healthy subjects (11 male and 11 female aged 25.9 ± 4.2 years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120 min afterward with the Proseek Multiplex Neurology I kit. Results: The levels for 13 biomarkers decreased significantly (p < .001) 30 min after food intake. The levels for four biomarkers remained significantly decreased (p < .001) 120 min after food intake. One biomarker increased significantly (p < .001) 30 min after food intake. The changes were between 1% and 12%, with an average difference of about 5%. Only one biomarker showed a difference over 10% due to food intake. The biggest difference was observed for Plexin-B3 120 min after food intake (12%). Of all the 92 neurological biomarkers, only one was correlated with BMI, Kynureninase r = .46, p < .05. Conclusions: This study shows that food intake has a very modest effect on 92 different neurological biomarkers. Timing of blood sampling in relation to food intake, therefore, appears not to be a major concern. Only Kynureninase was correlated with BMI. Further studies are warranted in older healthy subjects and in patients with various neurological diseases to determine whether the findings are reproducible in such populations.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Olink, Proseek Multiplex Neurology I
in
Brain and Behavior
publisher
John Wiley & Sons
external identifiers
  • scopus:85026656054
ISSN
2157-9032
DOI
10.1002/brb3.747
language
English
LU publication?
yes
id
e6bf7960-56af-489b-81fa-76581be79087
date added to LUP
2017-09-01 10:54:47
date last changed
2017-09-01 10:54:47
@article{e6bf7960-56af-489b-81fa-76581be79087,
  abstract     = {<p>Objective: This study evaluates the effect of food intake on 92 neurological biomarkers in plasma. Moreover, it investigated if any of the biomarkers were correlated with body mass index. Materials and Methods: Twenty-two healthy subjects (11 male and 11 female aged 25.9 ± 4.2 years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120 min afterward with the Proseek Multiplex Neurology I kit. Results: The levels for 13 biomarkers decreased significantly (p &lt; .001) 30 min after food intake. The levels for four biomarkers remained significantly decreased (p &lt; .001) 120 min after food intake. One biomarker increased significantly (p &lt; .001) 30 min after food intake. The changes were between 1% and 12%, with an average difference of about 5%. Only one biomarker showed a difference over 10% due to food intake. The biggest difference was observed for Plexin-B3 120 min after food intake (12%). Of all the 92 neurological biomarkers, only one was correlated with BMI, Kynureninase r = .46, p &lt; .05. Conclusions: This study shows that food intake has a very modest effect on 92 different neurological biomarkers. Timing of blood sampling in relation to food intake, therefore, appears not to be a major concern. Only Kynureninase was correlated with BMI. Further studies are warranted in older healthy subjects and in patients with various neurological diseases to determine whether the findings are reproducible in such populations.</p>},
  author       = {Dencker, Magnus and Björgell, Ola and Hlebowicz, Joanna},
  issn         = {2157-9032},
  keyword      = {Olink,Proseek Multiplex Neurology I},
  language     = {eng},
  publisher    = {John Wiley & Sons},
  series       = {Brain and Behavior},
  title        = {Effect of food intake on 92 neurological biomarkers in plasma},
  url          = {http://dx.doi.org/10.1002/brb3.747},
  year         = {2017},
}