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Immunomodulation in surgical practise

Andersson, Roland LU ; Andersson, Bodil LU ; Andersson, Ellen LU ; Eckerwall, Gunilla LU ; Nordén, Morgan LU and Tingstedt, Bobby LU (2006) In HPB 8(2). p.116-123
Abstract
Background. Immunomodulation may represent a potential way to improve surgical outcome. These types of interventions should be based on detailed knowledge of the underlying mechanisms involved. The aim of the present review is to summarize some experience on the acute phase response, potential ways of intervention and experiences from critical illness and HPB disease. Discussion. Mechanisms of the acute phase response are discussed including the individual parameters and local changes that take part. Mechanisms involved in failure of the gut barrier are presented and include changes in gut barrier permeability, effects on gut-associated immunocompetent cells, and systemic implications. As examples of HPB disease, mechanisms of the acute... (More)
Background. Immunomodulation may represent a potential way to improve surgical outcome. These types of interventions should be based on detailed knowledge of the underlying mechanisms involved. The aim of the present review is to summarize some experience on the acute phase response, potential ways of intervention and experiences from critical illness and HPB disease. Discussion. Mechanisms of the acute phase response are discussed including the individual parameters and local changes that take part. Mechanisms involved in failure of the gut barrier are presented and include changes in gut barrier permeability, effects on gut-associated immunocompetent cells, and systemic implications. As examples of HPB disease, mechanisms of the acute phase response and potential ways of intervention in obstructive jaundice and acute pancreatitis are discussed. Nutritional pharmacology and lessons learned from immunomodulation and immunonutrition in critical illness and major abdominal surgery, including upper GI and HPB surgery, are referred to. Overall, immunomodulation represents a potential tool to improve results but requires a thorough mapping of underlying mechanisms in order to achieve individualized treatment or prevention based on patients' specific needs. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acute phase response, critical illness, immunomodulation, surgery, cytokines, immunonutrition
in
HPB
volume
8
issue
2
pages
116 - 123
publisher
Informa Healthcare
external identifiers
  • scopus:33646079857
  • pmid:18333259
ISSN
1477-2574
DOI
10.1080/13651820410016660
language
English
LU publication?
yes
id
e6eebe73-955d-48b2-82fe-fa3175bb79af (old id 1137122)
date added to LUP
2008-04-01 08:37:59
date last changed
2019-02-20 04:49:25
@article{e6eebe73-955d-48b2-82fe-fa3175bb79af,
  abstract     = {Background. Immunomodulation may represent a potential way to improve surgical outcome. These types of interventions should be based on detailed knowledge of the underlying mechanisms involved. The aim of the present review is to summarize some experience on the acute phase response, potential ways of intervention and experiences from critical illness and HPB disease. Discussion. Mechanisms of the acute phase response are discussed including the individual parameters and local changes that take part. Mechanisms involved in failure of the gut barrier are presented and include changes in gut barrier permeability, effects on gut-associated immunocompetent cells, and systemic implications. As examples of HPB disease, mechanisms of the acute phase response and potential ways of intervention in obstructive jaundice and acute pancreatitis are discussed. Nutritional pharmacology and lessons learned from immunomodulation and immunonutrition in critical illness and major abdominal surgery, including upper GI and HPB surgery, are referred to. Overall, immunomodulation represents a potential tool to improve results but requires a thorough mapping of underlying mechanisms in order to achieve individualized treatment or prevention based on patients' specific needs.},
  author       = {Andersson, Roland and Andersson, Bodil and Andersson, Ellen and Eckerwall, Gunilla and Nordén, Morgan and Tingstedt, Bobby},
  issn         = {1477-2574},
  keyword      = {acute phase response,critical illness,immunomodulation,surgery,cytokines,immunonutrition},
  language     = {eng},
  number       = {2},
  pages        = {116--123},
  publisher    = {Informa Healthcare},
  series       = {HPB},
  title        = {Immunomodulation in surgical practise},
  url          = {http://dx.doi.org/10.1080/13651820410016660},
  volume       = {8},
  year         = {2006},
}